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Expression of the Baculovirus p35 Gene Inhibits Mammalian Neural Cell Death
Abstract
Expression of the apoptosis suppressor genep35, derived from the baculovirus Autographa californica nuclear polyhedrosis virus, markedly inhibited the cell death of stably transfected mammalian neural cells whether the cell death was induced by glucose withdrawal, calcium ionophore, or serum withdrawal. The p35 protein, which is required to block virus‐induced apoptosis of cultured insect cells, is only the second gene product shown to block mammalian neural cell death, with Bcl‐2 being the first. Because there is no apparent homology between p35 and Bcl‐2, the existence of a cellular death program that may be modulated at multiple points is suggested/Furthermore, these findings demonstrate that the putative cellular death program is conserved across species and cell types.
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Citations
Cited by
Apoptosis in the Pathogenesis and Treatment of Disease
Thompson, C. B. (1995) · Science · doi:10.1126/science.7878464 · Cited by 6,524
Life, death, and the pursuit of apoptosis.
White, E. (1996) · Genes & Development · doi:10.1101/gad.10.1.1 · Cited by 1,311
Drosophila homologs of baculovirus inhibitor of apoptosis proteins function to block cell death
Hay, B. A., Wassarman, D. A., & Rubin, G. M. (1995) · Cell · doi:10.1016/0092-8674(95)90150-7 · Cited by 729
The head involution defective gene of Drosophila melanogaster functions in programmed cell death.
Grether, M. E., Abrams, J. M., Agapite, J., White, K., & Steller, H. (1995) · Genes & Development · doi:10.1101/gad.9.14.1694 · Cited by 699
Caulín, C., Salvesen, G. S., & Oshima, R. G. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.138.6.1379 · Cited by 591
Metadata
- Authors
- Rabizadeh, S., LaCount, D. J., Friesen, P. D., & Bredesen, D. E.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 1993-12
- Volume
- 61
- Issue
- 6
- Pages
- 2318-2321
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W2167264857
- Cited by
- 193
- References
- 0
- FWCI
- 8.37
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rabizadeh, S., LaCount, D. J., Friesen, P. D., & Bredesen, D. E. (1993). Expression of the Baculovirus p35 Gene Inhibits Mammalian Neural Cell Death. Journal of Neurochemistry. https://doi.org/10.1111/j.1471-4159.1993.tb07477.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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