The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Nanomolar concentrations of kynurenic acid reduce extracellular dopamine levels in the striatum
Abstract
Precise regulation of dopaminergic activity is of obvious importance for the physiology and pathology of basal ganglia. We report here that nanomolar concentrations of the astrocyte‐derived neuroinhibitory metabolite kynurenic acid (KYNA) potently reduce the extracellular levels of striatal dopamine in unanesthetized rats in vivo. This effect, which is initiated by the KYNA‐induced blockade of α7 nicotinic acetylcholine receptors, highlights the functional relevance of glia–neuron interactions in the striatum and indicates that even modest increases in the brain levels of endogenous KYNA are capable of interfering with dopaminergic neurotransmission.
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Cites
Glutamate, Dopamine, and Schizophrenia: From Pathophysiology to Treatment
LARUELLE, M., KEGELES, L. S., & ABI‐DARGHAM, A. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1300.063 · Cited by 437
Cited by
Mammalian nicotinic acetylcholine receptors: from structure to function
Albuquerque, E. X., Pereira, E. F. R., Alkondon, M., & Rogers, S. W. (2009) · Physiological Reviews · doi:10.1152/physrev.00015.2008 · Cited by 1,724
Verkhratsky, A., & Nedergaard, M. (2018) · Physiological Reviews · doi:10.1152/physrev.00042.2016 · Cited by 1,678
Kynurenines in the mammalian brain: when physiology meets pathology
Schwarcz, R., Bruno, J. P., Muchowski, P. J., & Wu, H.-Q. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3257 · Cited by 1,530
Self-citationKynurenine Pathway Metabolites in Humans: Disease and Healthy States
Chen, Y., & Guillemin, G. J. (2009) · International Journal of Tryptophan Research · doi:10.4137/ijtr.s2097 · Cited by 628
Tryptophan Metabolic Pathways and Brain Serotonergic Activity: A Comparative Review
Höglund, E., Øverli, Ø., & Winberg, S. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00158 · Cited by 438
Metadata
- Authors
- Rassoulpour, A., Wu, H., Ferrė, S., & Schwarcz, R.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 2005-04-07
- Volume
- 93
- Issue
- 3
- Pages
- 762-765
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W2083373623
- Cited by
- 174
- References
- 1
- FWCI
- 2.44
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rassoulpour, A., Wu, H., Ferrė, S., & Schwarcz, R. (2005). Nanomolar concentrations of kynurenic acid reduce extracellular dopamine levels in the striatum. Journal of Neurochemistry. https://doi.org/10.1111/j.1471-4159.2005.03134.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
