Mammalian nicotinic acetylcholine receptors: from structure to function

Albuquerque, Edson X.; Pereira, Edna F. R.; Alkondon, Manickavasagom; Rogers, Scott W.

doi:10.1152/physrev.00015.2008

Cited by 1,724Nicotinic Acetylcholine Receptors StudyNeuroscience and Neuropharmacology ResearchSmoking Behavior and Cessation

Mammalian nicotinic acetylcholine receptors: from structure to function

Open access

Albuquerque, Edson X., Pereira, Edna F. R., Alkondon, Manickavasagom, Rogers, Scott W.·2009·Physiological Reviews

DOI 10.1152/physrev.00015.2008PMC PMC2713585

Open this paper in CoChat — free account

Abstract

The classical studies of nicotine by Langley at the turn of the 20th century introduced the concept of a "receptive substance," from which the idea of a "receptor" came to light. Subsequent studies aided by the Torpedo electric organ, a rich source of muscle-type nicotinic receptors (nAChRs), and the discovery of alpha-bungarotoxin, a snake toxin that binds pseudo-irreversibly to the muscle nAChR, resulted in the muscle nAChR being the best characterized ligand-gated ion channel hitherto. With the advancement of functional and genetic studies in the late 1980s, the existence of nAChRs in the mammalian brain was confirmed and the realization that the numerous nAChR subtypes contribute to the psychoactive properties of nicotine and other drugs of abuse and to the neuropathology of various diseases, including Alzheimer's, Parkinson's, and schizophrenia, has since emerged. This review provides a comprehensive overview of these findings and the more recent revelations of the impact that the rich diversity in function and expression of this receptor family has on neuronal and nonneuronal cells throughout the body. Despite these numerous developments, our understanding of the contributions of specific neuronal nAChR subtypes to the many facets of physiology throughout the body remains in its infancy.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1152/physrev.00015.2008

Cites

582 of 582 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Nicotine generally acts in the central nervous system through nicotinic acetylcholine receptors.
“Nicotine generally exerts its effects in the central nervous system (CNS) via an interaction at nicotinic acetylcholine receptors (nAChRs) (Albuquerque et al., 2009;Gotti et al., 2009).”
From Nicotinic receptor-mediated reduction in l-DOPA-induced dyskinesias may occur via desensitization (2010) · cites this paper as Albuquerque et al., 2009

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

UCSF Chimera—A visualization system for exploratory research and analysis
Pettersen, E. F., Goddard, T. D., Huang, C. C., Couch, G. S., Greenblatt, D. M., Meng, E. C., & Ferrin, T. E. (2004) · Journal of Computational Chemistry · doi:10.1002/jcc.20084 · Cited by 45,260 · see citing works
Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches
Hamill, O. P., Marty, A., Neher, E., Sakmann, B., & Sigworth, F. J. (1981) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00656997 · Cited by 18,436 · see citing works
International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels
Catterall, W. A., Chandy, K. G., Clapham, D. E., Gutman, G. A., Hofmann, F., Harmar, A. J., Abernethy, D. R., & Spedding, M. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.4.5 · Cited by 7,126 · see citing works
Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor
Devane, W. A., Hanuš, L., Breuer, A., Pertwee, R. G., Stevenson, L. A., Griffin, G., Gibson, D., Mandelbaum, A., Etinger, A., & Mechoulam, R. (1992) · Science · doi:10.1126/science.1470919 · Cited by 5,633 · see citing works
Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.
Greene, L., & Tischler, A. S. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.7.2424 · Cited by 5,594 · see citing works
Interneurons of the hippocampus
Freund, T. F., & Buzsáki, G. (1998) · Hippocampus · doi:10.1002/(sici)1098-1063(1996)6:4 · Cited by 3,423 · see citing works
Nicotinic acetylcholine receptor α7 subunit is an essential regulator of inflammation
Wang, H., Yu, M., Ochani, M., Amella, C. A., Tanovic, M., Susarla, S., Li, J. H., Wang, H., Yang, H., Ulloa, L., et al. (2003) · Nature · doi:10.1038/nature01339 · Cited by 3,228 · see citing works
Cyclooxygenases: Structural, cellular, and molecular biology
Smith, W. L., DeWitt, D. L., & Garavito, R. M. (2000) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.69.1.145 · Cited by 2,925 · see citing works
Quantal components of the end‐plate potential
del Castillo, J., & Katz, B. (1954) · The Journal of Physiology · doi:10.1113/jphysiol.1954.sp005129 · Cited by 2,201 · see citing works
Astrocytes, from brain glue to communication elements: the revolution continues
Volterra, A., & Meldolesi, J. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1722 · Cited by 1,763 · see citing works
Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors
Brejc, K., van Dijk, W. J., Klaassen, R. V., Schuurmans, M., John van der, O. O. S. T., Smit, A. B., & Sixma, T. K. (2001) · Nature · doi:10.1038/35077011 · Cited by 1,761 · see citing works
Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways
Hardingham, G. E., Fukunaga, Y., & Bading, H. (2002) · Nature Neuroscience · doi:10.1038/nn835 · Cited by 1,686 · see citing works
Refined Structure of the Nicotinic Acetylcholine Receptor at 4Å Resolution
Unwin, N. C. (2004) · Journal of Molecular Biology · doi:10.1016/j.jmb.2004.12.031 · Cited by 1,661 · see citing works
Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses
Wilson, R. I., & Nicoll, R. A. (2001) · Nature · doi:10.1038/35069076 · Cited by 1,607 · see citing works
Synchronization of neuronal activity in hippocampus by individual GABAergic interneurons
Cobb, S. R., Buhl, E. H., Halasy, K., Paulsen, O., & Somogyi, P. (1995) · Nature · doi:10.1038/378075a0 · Cited by 1,498 · see citing works
Molecular cloning, functional properties, and distribution of rat brain alpha 7: a nicotinic cation channel highly permeable to calcium
Séguéla, P., Wadiche, J. I., Dineley‐Miller, K., Dani, J., & Jw, P. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-02-00596.1993 · Cited by 1,471 · see citing works
A study of the ‘desensitization’ produced by acetylcholine at the motor end‐plate
Katz, B., & Thesleff, S. (1957) · The Journal of Physiology · doi:10.1113/jphysiol.1957.sp005838 · Cited by 1,463 · see citing works
Bursts as a unit of neural information: making unreliable synapses reliable
Lisman, J. E. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)10070-9 · Cited by 1,412 · see citing works
Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies
Crawley, J. N., Belknap, J. K., Collins, A. C., Crabbe, J. C., Frankel, W. N., Henderson, N. D., HITZEMANN, R. J., Maxson, S. C., Miner, L. L., Silva, A. J., et al. (1997) · Psychopharmacology · doi:10.1007/s002130050327 · Cited by 1,372 · see citing works
Presynaptic nicotinic ACh receptors
Wonnacott, S. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)10073-4 · Cited by 1,308 · see citing works
Active Smoking and the Risk of Type 2 Diabetes: A Systematic Review and Meta-analysis
Willi, C., Bodenmann, P., Ghali, W. A., Faris, P. D., & Cornuz, J. (2007) · JAMA · doi:10.1001/jama.298.22.2654 · Cited by 1,268 · see citing works
Expression of a mitogen-inducible cyclooxygenase in brain neurons: Regulation by synaptic activity and glucocorticoids
Yamagata, K., Andreasson, K. I., Kaufmann, W. E., Barnes, C. A., & Worley, P. F. (1993) · Neuron · doi:10.1016/0896-6273(93)90192-t · Cited by 1,224 · see citing works
Nicotinic Acetylcholine Receptors and Nicotinic Cholinergic Mechanisms of the Central Nervous System
Dani, J. A., & Bertrand, D. (2007) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.47.120505.105214 · Cited by 1,197 · see citing works
The release of neural transmitter substances
Katz, B. (1969) · Medical Entomology and Zoology · Cited by 1,114 · see citing works
Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway
de Jonge, W. J., van der Zanden, E. P., The, F. O., Bijlsma, M. F., van Westerloo, D. J., Bennink, R. J., Berthoud, H.-R., Uematsu, S., Akira, S., van den Wijngaard, R. M., et al. (2005) · Nature Immunology · doi:10.1038/ni1229 · Cited by 1,074 · see citing works
Nicotine enhancement of fast excitatory synaptic transmission in CNS by presynaptic receptors
McGehee, D. S., Heath, M. J. S., Gelber, S., Devay, P., & Role, L. W. (1995) · Science · doi:10.1126/science.7569895 · Cited by 1,070 · see citing works
Distribution of alpha2, alpha3, alpha4, and beta2 neuronal nicotinic receptor subunit mRNAs in the central nervous system: A hybridization histochemical study in the rat
Wada, E., Wada, K., Boulter, J., Deneris, E. S., Heinemann, S., Patrick, J., & Swanson, L. W. (1989) · The Journal of Comparative Neurology · doi:10.1002/cne.902840212 · Cited by 1,044 · see citing works
Neuronal nicotinic receptors: from structure to pathology
Gotti, C., & Clementi, F. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.09.006 · Cited by 970 · see citing works
Hippocampal synaptic transmission enhanced by low concentrations of nicotine
Gray, R. G. F., Rajan, A. S., Radcliffe, K. A., Yakehiro, M., & Dani, J. A. (1996) · Nature · doi:10.1038/383713a0 · Cited by 947 · see citing works
A neuronal nicotinic acetylcholine receptor subunit (α7) is developmentally regulated and forms a homo-oligomeric channel blocked by α-BTX
Couturier, S., Bertrand, D., Matter, J., Hernandez, M., Bertrand, S., Millar, N. S., Valera, S., BARKAS, T., & Ballivet, M. (1990) · Neuron · doi:10.1016/0896-6273(90)90344-f · Cited by 941 · see citing works
Microglia as neuroprotective, immunocompetent cells of the CNS
Streit, W. J. (2002) · Glia · doi:10.1002/glia.10154 · Cited by 919 · see citing works
Brain nicotinic acetylcholine receptors: native subtypes and their relevance
Gotti, C., Zoli, M., & Clementi, F. (2006) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2006.07.004 · Cited by 882 · see citing works
A subtype of nicotinic cholinergic receptor in rat brain is composed of alpha 4 and beta 2 subunits and is up-regulated by chronic nicotine treatment.
Flores, C. M., Rogers, S. W., Pabreza, L. A., Wolfe, B. B., & Kellar, K. J. (1992) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)08832-7 · Cited by 880 · see citing works
Über humorale übertragbarkeit der Herznervenwirkung
Loewi, O. (1921) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf01738910 · Cited by 864 · see citing works
β-Amyloid1–42 Binds to α7 Nicotinic Acetylcholine Receptor with High Affinity
Wang, H.-Y., Lee, D. H. S., D’Andrea, M. R., Peterson, P. A., Shank, R. P., & Reitz, A. B. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.8.5626 · Cited by 818 · see citing works
A patch-clamp study of bovine chromaffin cells and of their sensitivity to acetylcholine
Fenwick, E. M., Marty, A., & Neher, E. (1982) · The Journal of Physiology · doi:10.1113/jphysiol.1982.sp014393 · Cited by 812 · see citing works
Structural homology of Torpedo californica acetylcholine receptor subunits
Noda, M., Takahashi, H. K., Tanabe, T., et al. (1983) · Nature · doi:10.1038/302528a0 · Cited by 801 · see citing works
Nicotine and Carbamylcholine Binding to Nicotinic Acetylcholine Receptors as Studied in AChBP Crystal Structures
Celie, P. H. N., van Rossum-Fikkert, S. E., van Dijk, W. J., Brejc, K., Smit, A. B., & Sixma, T. K. (2004) · Neuron · doi:10.1016/s0896-6273(04)00115-1 · Cited by 781 · see citing works
The Brain Metabolite Kynurenic Acid Inhibits α7 Nicotinic Receptor Activity and Increases Non-α7 Nicotinic Receptor Expression: Physiopathological Implications
Hilmas, C., Pereira, E., Alkondon, M., Rassoulpour, A., Schwarcz, R., & Albuquerque, E. X. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-19-07463.2001 · Cited by 772 · see citing works
Self-citation
Nicotine activates and desensitizes midbrain dopamine neurons
Pidoplichko, V. I., DeBiasi, M., Williams, J. T., & Dani, J. A. (1997) · Nature · doi:10.1038/37120 · Cited by 769 · see citing works
Trends in head and neck cancer incidence in relation to smoking prevalence
Sturgis, E. M., & Cinciripini, P. M. (2007) · Cancer · doi:10.1002/cncr.22963 · Cited by 754 · see citing works
Primary structure of α-subunit precursor of Torpedo californica acetylcholine receptor deduced from cDNA sequence
Noda, M., Takahashi, H. K., Tanabe, T., Toyosato, M., Furutani, Y., Hirose, T., Asai, M., Inayama, S., Miyata, T., & Numa, S. (1982) · Nature · doi:10.1038/299793a0 · Cited by 735 · see citing works
The role of inflammation in Alzheimer’s disease
Tuppo, E. E., & Arias, H. R. (2005) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.07.009 · Cited by 734 · see citing works
Long-term potentiation of excitatory inputs to brain reward areas by nicotine
Mansvelder, H. D., & McGehee, D. S. (2000) · Neuron · doi:10.1016/s0896-6273(00)00042-8 · Cited by 720 · see citing works
Synaptic mechanisms underlie nicotine-induced excitability of brain reward areas
Mansvelder, H. D., Keath, J. R., & McGehee, D. S. (2002) · Neuron · doi:10.1016/s0896-6273(02)00625-6 · Cited by 701 · see citing works
A further study of the statistical composition of the end‐plate potential
Martin, A. R. (1955) · The Journal of Physiology · doi:10.1113/jphysiol.1955.sp005397 · Cited by 698 · see citing works
Nicotine Activation of α4* Receptors: Sufficient for Reward, Tolerance, and Sensitization
Tapper, A. R., McKinney, S. L., Nashmi, R., Schwarz, J., Deshpande, P., Labarca, C., Whiteaker, P., Marks, M. J., Collins, A. C., & Lester, H. A. (2004) · Science · doi:10.1126/science.1099420 · Cited by 686 · see citing works
Nicotinic acetylcholine involvement in cognitive function in animals
Levin, E. D., & Simon, B. B. (1998) · Psychopharmacology · doi:10.1007/s002130050667 · Cited by 675 · see citing works
Alzheimer’s disease and the basal forebrain cholinergic system: relations to β-amyloid peptides, cognition, and treatment strategies
Auld, D. S., Kornecook, T. J., Bastianetto, S., & Quirion, R. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00079-5 · Cited by 669 · see citing works
THE ACTION OF CERTAIN ESTERS AND ETHERS OF CHOLINE, AND THEIR RELATION TO MUSCARINE
Dale, H. H. (1914) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)08268-0 · Cited by 658 · see citing works
Bidirectional synaptic plasticity induced by a single burst during cholinergic theta oscillation in CA1 in vitro
Huerta, P. T., & Lisman, J. E. (1995) · Neuron · doi:10.1016/0896-6273(95)90094-2 · Cited by 646 · see citing works
The Influence of Age and Sex on the Onset and Early Course of Schizophrenia
Häfner, H., Maurer, K., Löffler, W., & Riecher-Rössler, A. (1993) · British Journal of Psychiatry · doi:10.1192/bjp.162.1.80 · Cited by 644 · see citing works
Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations
Hansen, S. B., Sulzenbacher, G., Huxford, T., Marchot, P., Taylor, P., & Bourne, Y. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600828 · Cited by 643 · see citing works
I. The Croonian Lecture
Wollaston, W. H. (1810) · Philosophical Transactions of the Royal Society of London · doi:10.1098/rstl.1810.0002 · Cited by 624 · see citing works
On the reaction of cells and of nerve‐endings to certain poisons, chiefly as regards the reaction of striated muscle to nicotine and to curari
Langley, J. N. (1905) · The Journal of Physiology · doi:10.1113/jphysiol.1905.sp001128 · Cited by 608 · see citing works
Increased cortical kynurenate content in schizophrenia
Schwarcz, R., Rassoulpour, A., Wu, H.-Q., Medoff, D., Tamminga, C. A., & Roberts, R. C. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01078-2 · Cited by 590 · see citing works
PRESYNAPTIC IONOTROPIC RECEPTORS AND THE CONTROL OF TRANSMITTER RELEASE
MacDermott, A. B., Role, L. W., & Siegelbaum, S. A. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.443 · Cited by 570 · see citing works
Both alpha- and beta-subunits contribute to the agonist sensitivity of neuronal nicotinic acetylcholine receptors
Luetje, C., & Patrick, J. (1991) · The Journal of Neuroscience · doi:10.1523/jneurosci.11-03-00837.1991 · Cited by 558 · see citing works
Manipulation of Brain Kynurenines: Glial Targets, Neuronal Effects, and Clinical Opportunities
Schwarcz, R. M., & Pellicciari, R. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.034439 · Cited by 556 · see citing works
Diversity of nicotinic acetylcholine receptors in rat hippocampal neurons. I. Pharmacological and functional evidence for distinct structural subtypes.
Alkondon, M., & Albuquerque, E. X. (1993) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)38283-2 · Cited by 554 · see citing works
Self-citation
Differential regulation of neocortical synapses by neuromodulators and activity
Gil, Z., Connors, B. W., & Amitai, Y. (1997) · Neuron · doi:10.1016/s0896-6273(00)80380-3 · Cited by 553 · see citing works
Evidence that Tobacco Smoking Increases the Density of (−)‐[3H]Nicotine Binding Sites in Human Brain
Benwell, M. E. M., Balfour, D. J. K., & Anderson, J. M. (1988) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1988.tb10600.x · Cited by 551 · see citing works
Global Analysis of Protein Palmitoylation in Yeast
Roth, A. F., Wan, J., Bailey, A. O., Sun, B., Kuchar, J. A., Green, W. N., Phinney, B. S., Yates, J. R., & Davis, N. G. (2006) · Cell · doi:10.1016/j.cell.2006.03.042 · Cited by 540 · see citing works
A receptor for protons in the nerve cell membrane
Krishtal, O., & Pidoplichko, V. I. (1980) · Neuroscience · doi:10.1016/0306-4522(80)90149-9 · Cited by 540 · see citing works
International Union of Pharmacology. XX. Current Status of the Nomenclature for Nicotinic Acetylcholine Receptors and Their Subunits
Lukas, R. J., Changeux, J., Novère, N. G. L., Albuquerque, E. X., Balfour, D. J. K., Berg, D. K., Bertrand, D., Chiappinelli, V. A., Clarke, P. B. S., Collins, A. C., et al. (1999) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01406-6 · Cited by 536 · see citing works
Self-citation
Primary structures of β- and δ-subunit precursors of Torpedo californica acetylcholine receptor deduced from cDNA sequences
Noda, M., Takahashi, H. K., Tanabe, T., et al. (1983) · Nature · doi:10.1038/301251a0 · Cited by 530 · see citing works
Nicotinic acetylcholine receptors: from structure to brain function
Hogg, R. C., Raggenbass, M., & Bertrand, D. (2003) · Springer eBooks · doi:10.1007/s10254-003-0005-1 · Cited by 529 · see citing works
On the localization of acetylcholine receptors
del Castillo, J., & Katz, B. (1955) · The Journal of Physiology · doi:10.1113/jphysiol.1955.sp005297 · Cited by 522 · see citing works
Recent advances in Cys-loop receptor structure and function
Sine, S. M., & Engel, A. G. (2006) · Nature · doi:10.1038/nature04708 · Cited by 521 · see citing works
Subunit Composition of Functional Nicotinic Receptors in Dopaminergic Neurons Investigated with Knock-Out Mice
Champtiaux, N., Gotti, C., Cordero‐Erausquin, M., David, D. J. P., Przybylski, C., Léna, C., Clementi, F., Moretti, M., Rossi, F., Novère, N. G. L., et al. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-21-07820.2003 · Cited by 509 · see citing works
Bupropion is a nicotinic antagonist
Slemmer, J. E., Martin, B. R., & Damaj, M. I. (2000) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38905-0 · Cited by 509 · see citing works
Mice Deficient in the α7 Neuronal Nicotinic Acetylcholine Receptor Lack α-Bungarotoxin Binding Sites and Hippocampal Fast Nicotinic Currents
Orr‐Urtreger, A., Göldner, F. M., Saeki, M., Lorenzo, I., Goldberg, L. B., Biasi, M. D., Dani, J. A., Patrick, J. W., & Beaudet, A. L. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-23-09165.1997 · Cited by 494 · see citing works
Über humorale Übertragbarkeit der Herznervenwirkung
Loewi, O., & Navratil, E. (1924) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf01722757 · Cited by 480 · see citing works
Relapse prevention interventions for smoking cessation
Hájek, P., Stead, L. F., West, R., Jarvis, M. J., Hartmann‐Boyce, J., & Lancaster, T. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003999.pub4 · Cited by 471 · see citing works
Calcium modulation and high calcium permeability of neuronal nicotinic acetylcholine receptors
Vernino, S. A., Amador, M., Luetje, C. W., Patrick, J., & Dani, J. A. (1992) · Neuron · doi:10.1016/0896-6273(92)90114-s · Cited by 468 · see citing works
NMDA-dependent modulation of CA1 local circuit inhibition
Grunze, H., Rainnie, D., Hasselmo, M., Barkai, E., Hearn, E., McCarley, R., & Greene, R. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-06-02034.1996 · Cited by 467 · see citing works
Laminar selectivity of the cholinergic suppression of synaptic transmission in rat hippocampal region CA1: computational modeling and brain slice physiology
Hasselmo, M., & Schnell, E. (1994) · The Journal of Neuroscience · doi:10.1523/jneurosci.14-06-03898.1994 · Cited by 466 · see citing works
Intracellular accumulation of β-amyloid1–42 in neurons is facilitated by the α7 nicotinic acetylcholine receptor in Alzheimer’s disease
Nagele, R. G., D’Andrea, M. R., Anderson, W. J., & Wang, H.-Y. (2002) · Neuroscience · doi:10.1016/s0306-4522(01)00460-2 · Cited by 456 · see citing works
Locus control regions
Li, Q., Peterson, K. R., Fang, X., & Stamatoyannopoulos, G. (2002) · Blood · doi:10.1182/blood-2002-04-1104 · Cited by 456 · see citing works
Pharmacological activity of the cannabinoid receptor agonist, anandamide, a brain constituent
Fride, E., & Mechoulam, R. (1993) · European Journal of Pharmacology · doi:10.1016/0014-2999(93)90468-w · Cited by 453 · see citing works
Tonic Activation of NMDA Receptors by Ambient Glutamate Enhances Excitability of Neurons
Sah, P., Hestrin, S., & Nicoll, R. A. (1989) · Science · doi:10.1126/science.2573153 · Cited by 443 · see citing works
Nicotinic acetylcholine receptors in health and disease
Lindstrom, J. (1997) · Molecular Neurobiology · doi:10.1007/bf02740634 · Cited by 443 · see citing works
Choline is a Selective Agonist of α7 Nicotinic Acetylcholine Receptors in the Rat Brain Neurons
Alkondon, M., Pereira, E. F. R., Cartes, W. S., Maelicke, A., & Albuquerque, E. X. (1997) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1997.tb01702.x · Cited by 441 · see citing works
Self-citation
Cellular and synaptic mechanisms of nicotine addiction
Mansvelder, H. D., & McGehee, D. S. (2002) · Journal of Neurobiology · doi:10.1002/neu.10148 · Cited by 438 · see citing works
Isolation of a cDNA clone coding for a possible neural nicotinic acetylcholine receptor α-subunit
Boulter, J., Evans, K., Goldman, D., Martin, G. A., Treco, D., Heinemann, S., & Patrick, J. (1986) · Nature · doi:10.1038/319368a0 · Cited by 437 · see citing works
Properties of Neuronal Nicotinic Acetylcholine Receptors: Pharmacological Characterization and Modulation of Synaptic Function,
Albuquerque, E. X., Alkondon, M., Pereira, E. F. R., Castro, N. G., Schrattenholz, A. S., Barbosa, C. T. F., Bonfante-Cabarcas, R. A., Aracava, Y., Eisenberg, H. M., & Maelicke, A. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36503-6 · Cited by 436 · see citing works
Self-citation
The Role of Estrogens in Schizophrenia Gender Differences
Seeman, M. V., & Lang, M. (1990) · Schizophrenia Bulletin · doi:10.1093/schbul/16.2.185 · Cited by 424 · see citing works
Alternate stoichiometries of α4β2 nicotinic acetylcholine receptors
Nelson, M. E., Kuryatov, A., Choi, C. H., Zhou, Y., & Lindstrom, J. (2003) · Molecular Pharmacology · doi:10.1124/mol.63.2.332 · Cited by 422 · see citing works
Timing and Location of Nicotinic Activity Enhances or Depresses Hippocampal Synaptic Plasticity
Ji, D., Lape, R., & Dani, J. A. (2001) · Neuron · doi:10.1016/s0896-6273(01)00332-4 · Cited by 419 · see citing works
Mutations in the channel domain of a neuronal nicotinic receptor convert ion selectivity from cationic to anionic
Galzi, J., Devillers‐Thiéry, A., Hussy, N., Bertrand, S., Changeux, J., & Bertrand, D. (1992) · Nature · doi:10.1038/359500a0 · Cited by 417 · see citing works
Identification of the alpha subunit half-cystine specifically labeled by an affinity reagent for the acetylcholine receptor binding site.
Kao, P. N., Dwork, A. J., Kaldany, R.-R., Silver, M. L., Wideman, J., Stein, S., & Karlin, A. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)71257-3 · Cited by 409 · see citing works
Subunit Composition and Pharmacology of Two Classes of Striatal Presynaptic Nicotinic Acetylcholine Receptors Mediating Dopamine Release in Mice
Salminen, O., Murphy, K. L., McIntosh, J. M., Drago, J., Marks, M. J., Collins, A. C., & Grady, S. R. (2004) · Molecular Pharmacology · doi:10.1124/mol.65.6.1526 · Cited by 401 · see citing works
Functional contributions of α5 subunit to neuronal acetylcholine receptor channels
Ramírez-Latorre, J. A., Yu, C., Qu, X., Perin, F., Karlin, A., & Role, L. W. (1996) · Nature · doi:10.1038/380347a0 · Cited by 397 · see citing works
α7 Nicotinic Receptor Transduces Signals to Phosphatidylinositol 3-Kinase to Block A β-Amyloid-induced Neurotoxicity*
Kihara, T., Shimohama, S., Sawada, H., Honda, K., Nakamizo, T., Shibasaki, H., Kume, T., & Akaike, A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008035200 · Cited by 393 · see citing works
Nicotine-induced increase in neuronal nicotinic receptors results from a decrease in the rate of receptor turnover
Peng, X., Gerzanich, V, Anand, R., Whiting, P. J., & Lindstrom, J. (1994) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09730-5 · Cited by 391 · see citing works
Identification of four classes of brain nicotinic receptors using beta2 mutant mice.
Zoli, M., Léna, C., Picciotto, M. R., & Changeux, J. (1998) · PubMed Central · doi:10.1523/jneurosci.18-12-04461.1996 · Cited by 387 · see citing works
Nicotinic receptor of acetylcholine: structure of an oligomeric integral membrane protein
Popot, J., & Changeux, J. (1984) · Physiological Reviews · doi:10.1152/physrev.1984.64.4.1162 · Cited by 377 · see citing works
Acetylcholine Activates an α-Bungarotoxin-Sensitive Nicotinic Current in Rat Hippocampal Interneurons, But Not Pyramidal Cells
Frazier, C. J., Rollins, Y. D., Breese, C. R., Leonard, S., Freedman, R., & Dunwiddie, T. V. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-04-01187.1998 · Cited by 374 · see citing works
Differential desensitization and distribution of nicotinic acetylcholine receptor subtypes in midbrain dopamine areas
Wooltorton, J. R. A., Pidoplichko, V. I., Broide, R. S., & Dani, J. A. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-08-03176.2003 · Cited by 363 · see citing works
Increased nicotinic receptors in brains from smokers: membrane binding and autoradiography studies
Perry, D. C., Dávila-Garcı́a, M. I., Stockmeier, C. A., & Kellar, K. J. (1999) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38304-1 · Cited by 362 · see citing works
The paradox of nicotinic acetylcholine receptor upregulation by nicotine
Wonnacott, S. (1990) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(90)90242-z · Cited by 357 · see citing works
Nicotinic receptor subtypes and cognitive function
Levin, E. D. (2002) · Journal of Neurobiology · doi:10.1002/neu.10151 · Cited by 354 · see citing works
Nicotinic cholinergic signaling in hippocampal astrocytes involves calcium-induced calcium release from intracellular stores
Sharma, G. G., & Vijayaraghavan, S. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.071540198 · Cited by 351 · see citing works
Calcium influx through nicotinic receptor in rat central neurons: Its relevance to cellular regulation
Mulle, C., Choquet, D., Korn, H., & Changeux, J. (1992) · Neuron · doi:10.1016/0896-6273(92)90115-t · Cited by 351 · see citing works
Assembly of Human Neuronal Nicotinic Receptor α5 Subunits with α3, β2, and β4 Subunits
Wang, F., Gerzanich, V., Wells, G. B., Anand, R., Peng, X.-D., Keyser, K. T., & Lindstrom, J. M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.30.17656 · Cited by 345 · see citing works
Galantamine Is an Allosterically Potentiating Ligand of Neuronal Nicotinic but Not of Muscarinic Acetylcholine Receptors
Samochocki, M., Höffle‐Maas, A., Fehrenbacher, A., Jostock, R., Ludwig, J., Christner, C., Radina, M., Zerlin, M., Ullmer, C., Pereira, E. F. R., et al. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.045773 · Cited by 345 · see citing works
Self-citation
Identification of Four Classes of Brain Nicotinic Receptors Using β2 Mutant Mice
Zoli, M., Léna, C., Picciotto, M. R., & Changeux, J. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-12-04461.1998 · Cited by 343 · see citing works
Immunohistochemical localization of neuronal nicotinic receptors in the rodent central nervous system
Swanson, L. W., Simmons, D. M., Whiting, P. J., & Lindström, J. (1987) · Journal of Neuroscience · doi:10.1523/jneurosci.07-10-03334.1987 · Cited by 342 · see citing works
A model of hippocampal memory encoding and retrieval: GABAergic control of synaptic plasticity
Paulsen, O., & Moser, E. I. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01205-8 · Cited by 338 · see citing works
Inflammatory cytokines IL-1 alpha, IL-1 beta, IL-6, and TNF-alpha impart neuroprotection to an excitotoxin through distinct pathways.
Carlson, N. G., Wieggel, W. A., Chen, J., Bacchi, A., Rogers, S. W., & Gahring, L. C. (1999) · PubMed · Cited by 336 · see citing works
Self-citation
Choline and Selective Antagonists Identify Two Subtypes of Nicotinic Acetylcholine Receptors that Modulate GABA Release from CA1 Interneurons in Rat Hippocampal Slices
Alkondon, M., Pereira, E. F. R., Eisenberg, H. M., & Albuquerque, E. X. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-07-02693.1999 · Cited by 332 · see citing works
Self-citation
Synaptic Potentials Mediated via α-Bungarotoxin-Sensitive Nicotinic Acetylcholine Receptors in Rat Hippocampal Interneurons
Frazier, C. J., Buhler, A. V., Weiner, J. L., & Dunwiddie, T. V. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-20-08228.1998 · Cited by 329 · see citing works
Neuronal nicotinic acetylcholine receptor activation modulates gamma-aminobutyric acid release from CA1 neurons of rat hippocampal slices.
Alkondon, M., Pereira, E. F. R., Barbosa, C. T. F., & Albuquerque, E. X. (1997) · PubMed · Cited by 326 · see citing works
Self-citation
The lymphocytic cholinergic system and its contribution to the regulation of immune activity
Kawashima, K., & Fujii, T. (2003) · Life Sciences · doi:10.1016/j.lfs.2003.09.037 · Cited by 324 · see citing works
Smoking, nicotine and Parkinson's disease
Quik, M. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.06.008 · Cited by 323 · see citing works
β-Amyloid peptide blocks the response of α7-containing nicotinic receptors on hippocampal neurons
Liu, Q.-S., Kawai, H., & Berg, D. (2001) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.081553598 · Cited by 316 · see citing works
Crystal structure of a Cbtx–AChBP complex reveals essential interactions between snake α‐neurotoxins and nicotinic receptors
Bourne, Y., Talley, T. T., Hansen, S. B., Taylor, P., & Marchot, P. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600620 · Cited by 316 · see citing works
Localization of Acetylcholine Receptor by 125 I-Labeled α-Bungarotoxin Binding at Mouse Motor Endplates
Fertuck, H. C., & Salpeter, M. M. (1974) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.71.4.1376 · Cited by 315 · see citing works
The endocannabinoid anandamide is a direct and selective blocker of the background K+ channel TASK‐1
Maingret, F., Patel, A. J., Lazdunski, M., & Honoré, É. (2001) · The EMBO Journal · doi:10.1093/emboj/20.1.47 · Cited by 313 · see citing works
Crystal structure of nicotinic acetylcholine receptor homolog AChBP in complex with an α-conotoxin PnIA variant
Celie, P. H. N., Kasheverov, I. E., Mordvintsev, D. Y., Hogg, R. C., van Nierop, P., van Elk, R., van Rossum-Fikkert, S. E., Zhmak, M. N., Bertrand, D., Tsetlin, V. I., et al. (2005) · Nature Structural & Molecular Biology · doi:10.1038/nsmb951 · Cited by 311 · see citing works
Alpha 3, alpha 5, and beta 4: three members of the rat neuronal nicotinic acetylcholine receptor-related gene family form a gene cluster.
Boulter, J., O'Shea-Greenfield, A., Duvoisin, R. M., Connolly, J. G., Wada, E., Jensen, A., Gardner, P. D., Ballivet, M., Deneris, E. S., & McKinnon, D. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39588-2 · Cited by 302 · see citing works
Inflammatory Cytokines IL-1α, IL-1β, IL-6, and TNF-α Impart Neuroprotection to an Excitotoxin Through Distinct Pathways
Carlson, N. G., Wieggel, W. A., Chen, J., Bacchi, A., Rogers, S. W., & Gahring, L. C. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.7.3963 · Cited by 301 · cited 2× · see citing works
“This leads to the speculation that the loss of α4-containing nAChRs could significantly increase susceptibility to age-associated insults by β-amyloid peptides, while loss of α7 nAChRs would enhance susceptibility to excitotoxic challenges such as those associated with ischemic damage or the presence of TNF-α (75,76).”
BackgroundSelf-citation
Neurons Can Maintain Multiple Classes of Nicotinic Acetylcholine Receptors Distinguished by Different Subunit Compositions
Conroy, W. G., & Berg, D. K. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.9.4424 · Cited by 297 · see citing works
Conus Peptides Targeted to Specific Nicotinic Acetylcholine Receptor Subtypes
McIntosh, J. M., Santos, A. D., & Olivera, B. M. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.59 · Cited by 295 · see citing works
Cyclooxygenase-2 Regulates Prostaglandin E2Signaling in Hippocampal Long-Term Synaptic Plasticity
Chen, C., Magee, J. C., & Bazan, N. G. (2002) · Journal of Neurophysiology · doi:10.1152/jn.2002.87.6.2851 · Cited by 293 · see citing works
β-Amyloid 1–42 Peptide Directly Modulates Nicotinic Receptors in the Rat Hippocampal Slice
Pettit, D. L., Shao, Z., & Yakel, J. L. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-01-j0003.2001 · Cited by 291 · see citing works
The functional diversity of the neuronal nicotinic acetylcholine receptors is increased by a novel subunit: β4
Duvoisin, R. M., Deneris, E. S., Patrick, J., & Heinemann, S. (1989) · Neuron · doi:10.1016/0896-6273(89)90207-9 · Cited by 291 · see citing works
The Development of Emphysema in Cigarette Smoke-exposed Mice Is Strain Dependent
Guerassimov, A., Hoshino, Y., Takubo, Y., Turcotte, A., Yamamoto, M., Ghezzo, H., Triantafillopoulos, A., Whittaker, K., Hoidal, J. R., & Cosío, M. G. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200309-1270oc · Cited by 286 · see citing works
Decreased Protein Levels of Nicotinic Receptor Subunits in the Hippocampus and Temporal Cortex of Patients with Alzheimer’s Disease
Guan, Z., Zhang, X., Ravid, R., & Nordberg, A. K. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0740237.x · Cited by 285 · see citing works
In Vivo Regulation of [3H]Acetylcholine Recognition Sites in Brain by Nicotinic Cholinergic Drugs
Schwartz, R. D., & Kellar, K. J. (1985) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1985.tb04005.x · Cited by 282 · see citing works
The non-neuronal cholinergic system in humans: Expression, function and pathophysiology
Wessler, I. K., Kilbinger, H. J., Bittinger, F., et al. (2003) · Life Sciences · doi:10.1016/s0024-3205(03)00083-3 · Cited by 278 · see citing works
An evaluation of neuronal nicotinic acetylcholine receptor activation by quaternary nitrogen compounds indicates that choline is selective for the α7 subtype
Papke, R. L., Bencherif, M., & Lippiello, P. M. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(96)12889-5 · Cited by 275 · see citing works
Precise Localization of α7 Nicotinic Acetylcholine Receptors on Glutamatergic Axon Terminals in the Rat Ventral Tegmental Area
Jones, I. W., & Wonnacott, S. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3009-04.2004 · Cited by 274 · see citing works
Principal pathway coupling agonist binding to channel gating in nicotinic receptors
Lee, W. Y., & Sine, S. M. (2005) · Nature · doi:10.1038/nature04156 · Cited by 273 · see citing works
alpha-Bungarotoxin-sensitive hippocampal nicotinic receptor channel has a high calcium permeability
Castro, N. G., & Albuquerque, E. X. (1995) · Biophysical Journal · doi:10.1016/s0006-3495(95)80213-4 · Cited by 273 · see citing works
Self-citation
The Croonian Lecture - The transmission of impulses from nerve to muscle, and the subcellular unit of synaptic action
Katz, B. (1962) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1962.0012 · Cited by 273 · see citing works
Functional nicotinic ACh receptors on interneurones in the rat hippocampus
Jones, S., & Yakel, J. L. (1997) · The Journal of Physiology · doi:10.1111/j.1469-7793.1997.603bd.x · Cited by 271 · see citing works
Analysis of Mecamylamine Stereoisomers on Human Nicotinic Receptor Subtypes
Papke, R. L., Sanberg, P. R., & Shytle, R. D. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29581-1 · Cited by 271 · see citing works
Stratum lacunosum-moleculare interneurons of hippocampal CA1 region. II. Intrasomatic and intradendritic recordings of local circuit synaptic interactions
Lacaille, J., & Schwartzkroin, P. (1988) · The Journal of Neuroscience · doi:10.1523/jneurosci.08-04-01411.1988 · Cited by 270 · see citing works
Nicotinic System Involvement in Alzheimer??s and Parkinson??s Diseases
NEWHOUSE, P. A., Potter, A., & Levin, E. D. (1997) · Drugs & Aging · doi:10.2165/00002512-199711030-00005 · Cited by 266 · see citing works
Time course study of the effects of chronic nicotine infusion on drug response and brain receptors
Marks, M. J., Stitzel, J. A., & Collins, A. C. (1985) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)24213-6 · Cited by 265 · see citing works
α-Bungarotoxin- and methyllycaconitine-sensitive nicotinic receptors mediate fast synaptic transmission in interneurons of rat hippocampal slices
Alkondon, M., Pereira, E. F. R., & Albuquerque, E. X. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00880-4 · Cited by 263 · see citing works
Self-citation
Nicotine Induces Glutamate Release from Thalamocortical Terminals in Prefrontal Cortex
Lambe, E. K., Picciotto, M. R., & Aghajanian, G. K. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300032 · Cited by 261 · see citing works
Evidence for "preterminal" nicotinic receptors on GABAergic axons in the rat interpeduncular nucleus
Léna, C., Changeux, J., & Mulle, C. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-06-02680.1993 · Cited by 255 · see citing works
Nicotine addiction: the possible role of functional upregulation
Buisson, B., & Bertrand, D. (2002) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)01979-9 · Cited by 254 · see citing works
Cigarette Smoking: Risk Factor for Premature Facial Wrinkling
Kadunce, D. P., Burr, R., Gress, R. E., Kanner, R. E., Lyon, J. L., & Zone, J. J. (1991) · Annals of Internal Medicine · doi:10.7326/0003-4819-114-10-840 · Cited by 253 · see citing works
Does Participation in Leisure Activities Lead to Reduced Risk of Alzheimer's Disease? A Prospective Study of Swedish Twins
Crowe, M., Andel, R., Pedersen, N. L., Johansson, B., & Gatz, M. (2003) · The Journals of Gerontology Series B: Psychological Sciences and Social Sciences · doi:10.1093/geronb/58.5.p249 · Cited by 252 · see citing works
Blockade of nicotinic currents in hippocampal neurons defines methyllycaconitine as a potent and specific receptor antagonist.
Alkondon, M., Pereira, E. F. R., Wonnacott, S., & Albuquerque, E. X. (1992) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09068-6 · Cited by 249 · see citing works
Self-citation
Nicotinic Receptor Activation in Human Cerebral Cortical Interneurons: a Mechanism for Inhibition and Disinhibition of Neuronal Networks
Alkondon, M., Pereira, E. F. R., Eisenberg, H. M., & Albuquerque, E. X. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-01-00066.2000 · Cited by 248 · see citing works
Self-citation
Rat α3/β4 Subtype of Neuronal Nicotinic Acetylcholine Receptor Stably Expressed in a Transfected Cell Line: Pharmacology of Ligand Binding and Function
Xiao, Y., Meyer, E. L., Thompson, J. M., Surin, A. M., Wroblewski, J. T., & Kellar, K. J. (1998) · Molecular Pharmacology · doi:10.1124/mol.54.2.322 · Cited by 247 · see citing works
Human Vascular Endothelial Cells Express Functional Nicotinic Acetylcholine Receptors
Macklin, K. D., Maus, A. D. J., Pereira, E. F. R., Albuquerque, E. X., & Conti‐Fine, B. M. (1998) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37807-3 · Cited by 247 · see citing works
Self-citation
Nonsteroidal anti-inflammatory drug use and Alzheimer-type pathology in aging
Mackenzie, I. R. A., & Munoz, D. G. (1998) · Neurology · doi:10.1212/wnl.50.4.986 · Cited by 244 · see citing works
β-Amyloid Peptide Activates α7 Nicotinic Acetylcholine Receptors Expressed in Xenopus Oocytes
Dineley, K. T., Bell, K. A., Bui, D., & Sweatt, J. D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200066200 · Cited by 241 · see citing works
Microglial α7 nicotinic acetylcholine receptors drive a phospholipase C/IP 3 pathway and modulate the cell activation toward a neuroprotective role
Suzuki, T., Hide, I., Matsubara, A., Hama, C., Harada, K., Miyano, K., Andrä, M., Matsubayashi, H., Sakai, N., Kohsaka, S., et al. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.20850 · Cited by 241 · see citing works
Nicotinic and muscarinic modulations of excitatory synaptic transmission in the rat prefrontal cortexin vitro
Vidal, C., & Changeux, J. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90558-w · Cited by 240 · see citing works
Nicotinic Acetylcholine Receptor α7 and α4β2 Subtypes Differentially Control GABAergic Input to CA1 Neurons in Rat Hippocampus
Alkondon, M., & Albuquerque, E. X. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.86.6.3043 · Cited by 240 · see citing works
Self-citation
Nicotinic Receptor Activation Excites Distinct Subtypes of Interneurons in the Rat Hippocampus
McQuiston, A. R., & Madison, D. V. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-08-02887.1999 · Cited by 239 · see citing works
Congenital Myasthenic Syndromes
Engel, A. G., Shen, X.-M., Ohno, K., & Sine, S. M. (1988) · Neuromuscular Disorders · doi:10.1002/9781119973331.ch19 · Cited by 239 · see citing works
Receptor-dependent formation of endogenous cannabinoids in cortical neurons
Stella, N., & Piomelli, D. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)01182-7 · Cited by 238 · see citing works
Kynurenine metabolism in Alzheimer's disease
Baran, H., Jellinger, K. A., & Deecke, L. (1999) · Journal of Neural Transmission · doi:10.1007/s007020050149 · Cited by 236 · see citing works
Biochemical properties of acetylcholine receptor subunits from Torpedo californica
Lindstrom, J. M., Merlie, J. P., & Yogeeswaran, G. (1979) · Biochemistry · doi:10.1021/bi00588a003 · Cited by 235 · see citing works
Human and Rodent Bronchial Epithelial Cells Express Functional Nicotinic Acetylcholine Receptors
Maus, A. D. J., Pereira, E. F. R., Karachunski, P. I., Horton, R. M., Navaneetham, D., Macklin, K., Cortes, W. S., Albuquerque, E. X., & Conti-Fine, B. M. (1998) · Molecular Pharmacology · doi:10.1124/mol.54.5.779 · Cited by 234 · see citing works
Self-citation
NATURE OF THE "ENDPLATE POTENTIAL" IN CURARIZED MUSCLE
Eccles, J. C., Katz, B., & Kuffler, S. W. (1941) · Journal of Neurophysiology · doi:10.1152/jn.1941.4.5.362 · Cited by 234 · see citing works
Inhibition and Disinhibition of Pyramidal Neurons by Activation of Nicotinic Receptors on Hippocampal Interneurons
Ji, D., & Dani, J. A. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.83.5.2682 · Cited by 231 · see citing works
Acetylcholine receptor α-, β-, γ-, and δ-subunit mRNA levels are regulated by muscle activity
Goldman, D. J., Brenner, H. R., & Heinemann, S. F. (1988) · Neuron · doi:10.1016/0896-6273(88)90081-5 · Cited by 229 · see citing works
Modulatory role of presynaptic nicotinic receptors in synaptic and non-synaptic chemical communication in the central nervous system
Vizi, E. S., & Lendvai, B. (1999) · Brain Research Reviews · doi:10.1016/s0165-0173(99)00016-8 · Cited by 228 · see citing works
Mutation Causing Autosomal Dominant Nocturnal Frontal Lobe Epilepsy Alters Ca2+Permeability, Conductance, and Gating of Human α4β2 Nicotinic Acetylcholine Receptors
Kuryatov, A., Gerzanich, V., Nelson, M. E., Olale, F., & Lindstrom, J. M. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-23-09035.1997 · Cited by 227 · see citing works
Sequential interplay of nicotinic and GABAergic signaling guides neuronal development
Liu, Z., Neff, R. A., & Berg, D. K. (2006) · Science · doi:10.1126/science.1134246 · Cited by 227 · see citing works
Human α6 AChR subtypes: subunit composition, assembly, and pharmacological responses
Kuryatov, A., Olale, F., Cooper, J., Choi, C. H., & Lindstrom, J. M. (2000) · Neuropharmacology · doi:10.1016/s0028-3908(00)00144-1 · Cited by 226 · see citing works
Non‐steroidal anti‐inflammatory drugs (NSAIDs) in Alzheimer's disease: old and new mechanisms of action
Gasparini, L., Ongini, E., & Wenk, G. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02743.x · Cited by 226 · see citing works
Agonist responses of neuronal nicotinic acetylcholine receptors are potentiated by a novel class of allosterically acting ligands.
Schrattenholz, A. S., Pereira, E. F. R., Roth, U., Weber, K. H., Albuquerque, E. X., & Maelicke, A. (1996) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)08675-4 · Cited by 226 · see citing works
Self-citation
Controlling inflammation: the cholinergic anti-inflammatory pathway
Pavlov, V. A., & Tracey, K. J. (2006) · Biochemical Society Transactions · doi:10.1042/bst0341037 · Cited by 221 · see citing works
Identification and quantification of kynurenic acid in human brain tissue
Turski, W. A., Nakamura, M., Todd, W. P., Carpenter, B. K., Whetsell, W. O., & Schwarcz, R. M. (1988) · Brain Research · doi:10.1016/0006-8993(88)90815-3 · Cited by 220 · see citing works
Neuronal α-Bungarotoxin Receptors Are α7 Subunit Homomers
Drisdel, R. C., & Green, W. N. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-01-00133.2000 · Cited by 218 · see citing works
Human Bronchial Epithelial and Endothelial Cells Express α7 Nicotinic Acetylcholine Receptors
Wang, Y., Pereira, E. F. R., Maus, A. D. J., Ostlie, N. S., Navaneetham, D., Lei, S., Albuquerque, E. X., & Conti-Fine, B. M. (2001) · Molecular Pharmacology · doi:10.1124/mol.60.6.1201 · Cited by 218 · see citing works
Self-citation
Rat Brain Slices Produce and Liberate Kynurenic Acid upon Exposure to l ‐Kynurenine
Turski, W. A., Gramsbergen, J. B., Traitler, H., et al. (1989) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1989.tb09218.x · Cited by 218 · see citing works
Rat nicotinic ACh receptor α7 and β2 subunits co‐assemble to form functional heteromeric nicotinic receptor channels
Khiroug, S. S., Harkness, P. C., Lamb, P. W., Sudweeks, S. N., Khiroug, L. S., Millar, N. S., & Yakel, J. L. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2001.013847 · Cited by 215 · see citing works
β-Amyloid Regulation of Presynaptic Nicotinic Receptors in Rat Hippocampus and Neocortex
Dougherty, J. J., Wu, J., & Nichols, R. A. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-17-06740.2003 · Cited by 213 · see citing works
Muscarinic Receptor Subtype Pharmacology and Physiology
Eglen, R. M. (2005) · Progress in medicinal chemistry · doi:10.1016/s0079-6468(05)43004-0 · Cited by 212 · see citing works
The electromotive action of acetylcholine at the motor end‐plate
Fatt, P. (1950) · The Journal of Physiology · doi:10.1113/jphysiol.1950.sp004492 · Cited by 212 · see citing works
The α7-nicotinic acetylcholine receptor and the pathology of hippocampal interneurons in schizophrenia
Freedman, R., Adams, C. E., & Leonard, S. S. (2000) · Journal of Chemical Neuroanatomy · doi:10.1016/s0891-0618(00)00109-5 · Cited by 212 · see citing works
The α7 nicotinic acetylcholine receptor in neuronal plasticity
Broide, R. S., & Leslie, F. M. (1999) · Molecular Neurobiology · doi:10.1007/bf02741361 · Cited by 210 · see citing works
A Nicotinic Acetylcholine Receptor Regulating Cell Adhesion and Motility Is Expressed in Human Keratinocytes
Grando, S. A., Horton, R. M., Pereira, E. F. R., Diethelm-Okita, B. M., George, P. M., Albuquerque, E. X., & Conti‐Fine, B. M. (1995) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12325606 · Cited by 210 · see citing works
Self-citation
Potentiation of Excitotoxicity in Transgenic Mice Overexpressing Neuronal Cyclooxygenase-2
Kelley, K. A., Ho, L., Winger, D. I., Freire-Moar, J., Borelli, C. B., Aisen, P. S. S., & Pasinetti, G. M. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65199-1 · Cited by 209 · see citing works
μ-Opioid Receptor and CREB Activation Are Required for Nicotine Reward
Walters, C. L., Cleck, J. N., Kuo, Y., & Blendy, J. A. (2005) · Neuron · doi:10.1016/j.neuron.2005.05.005 · Cited by 209 · see citing works
Membrane Lipid Rafts Are Necessary for the Maintenance of the α7 Nicotinic Acetylcholine Receptor in Somatic Spines of Ciliary Neurons
Brusés, J. L., Chauvet, N., & Rutishauser, U. S. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-02-00504.2001 · Cited by 208 · see citing works
The α5 gene product assembles with multiple acetylcholine receptor subunits to form distinctive receptor subtypes in brain
Conroy, W. G., Vernallis, A. B., & Berg, D. K. (1992) · Neuron · doi:10.1016/0896-6273(92)90031-8 · Cited by 208 · see citing works
Nicotinic receptors in aging and dementia
Picciotto, M. R., & Zoli, M. (2002) · Journal of Neurobiology · doi:10.1002/neu.10102 · Cited by 208 · see citing works
Increased neurodegeneration during ageing in mice lacking high‐affinity nicotine receptors
Zoli, M., Picciotto, M. R., Ferrari, R., Cocchi, D., & Changeux, J. (1999) · The EMBO Journal · doi:10.1093/emboj/18.5.1235 · Cited by 208 · see citing works
N-methyl-d-aspartate receptor antagonism in the ventral tegmental area diminishes the systemic nicotine-induced dopamine release in the nucleus accumbens
Schilström, B., Nomikos, G. G., Nisell, M., Hertel, P., & Svensson, T. H. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00243-1 · Cited by 206 · see citing works
Upregulation of Surface α4β2 Nicotinic Receptors Is Initiated by Receptor Desensitization after Chronic Exposure to Nicotine
Fenster, C. P., Whitworth, T. L., Sheffield, E. B., Quick, M. W., & Lester, R. A. J. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-12-04804.1999 · Cited by 204 · see citing works
Unconventional ligands and modulators of nicotinic receptors
Pereira, E. F. R., Hilmas, C. J., Santos, M. D., Alkondon, M., Maelicke, A., & Albuquerque, E. X. (2002) · Journal of Neurobiology · doi:10.1002/neu.10146 · Cited by 202 · see citing works
Self-citation
Conus Venom Peptides: Reflections from the Biology of Clades and Species
Olivera, B. M. (2002) · Annual Review of Ecology and Systematics · doi:10.1146/annurev.ecolsys.33.010802.150424 · Cited by 202 · see citing works
Nicotinic receptor subtypes in human brain ageing, Alzheimer and Lewy body diseases
Perry, E. K., Martin-Ruiz, C. M., Lee, M., Griffiths, M., Johnson, M., Piggott, M. A., Haroutunian, V. H., Buxbaum, J. D., Nãsland, J., Davis, K. L., et al. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00064-9 · Cited by 201 · see citing works
Chronic Nicotine Exposure Upregulates Nicotinic Receptors by a Novel Mechanism
Vallejo, Y. F. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.5240-04.2005 · Cited by 201 · see citing works
Existence of different subtypes of nicotinic acetylcholine receptors in the rat habenulo-interpeduncular system
Mulle, C., Vidal, C., Benoit, P., & Changeux, J. (1991) · Journal of Neuroscience · doi:10.1523/jneurosci.11-08-02588.1991 · Cited by 200 · see citing works
The nicotinic acetylcholine receptor subtypes and their function in the hippocampus and cerebral cortex
Alkondon, M., & Albuquerque, E. X. (2004) · Progress in brain research · doi:10.1016/s0079-6123(03)45007-3 · Cited by 197 · see citing works
Self-citation
Maturation of the Acetylcholine Receptor in Skeletal Muscle: Regulation of the AChR γ-to-ϵ Switch
Missias, A. C., Chu, G. C., Klocke, B. J., Sanes, J. R., & Merlie, J. P. (1996) · Developmental Biology · doi:10.1006/dbio.1996.0253 · Cited by 197 · see citing works
Functional and molecular characterization of neuronal nicotinic ACh receptors in rat CA1 hippocampal neurons
Sudweeks, S. N., & Yakel, J. L. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00515.x · Cited by 197 · see citing works
Changes in mitochondrial membrane potential during oxidative stress-induced apoptosis in PC12 cells
Satoh, T., Enokido, Y., Aoshima, H., Uchiyama, Y., & Hatanaka, H. (1997) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19971101)50:3 · Cited by 196 · see citing works

Flagged first, then by citations

Research works printed but not linked: 1

[493]Wang ZZ Fuhrer C Shtrom S Sugiyama JE Ferns MJ Hall ZW The nicotinic acetylcholine receptor at the neuromuscular junction: assembly and tyrosine phosphorylation Cold Spring Harb Symp Quant Biol 1996 61 363 371 9246465

Sorted by citations

Kynurenines in the mammalian brain: when physiology meets pathology
Schwarcz, R., Bruno, J. P., Muchowski, P. J., & Wu, H.-Q. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3257 · Cited by 1,530 · see citing works
Ketamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms
Zanos, P., Moaddel, R., Morris, P. J., Riggs, L. M., Highland, J. N., Georgiou, P., Pereira, E. F. R., Albuquerque, E. X., Thomas, C. J., Zarate, C. A., et al. (2018) · Pharmacological Reviews · doi:10.1124/pr.117.015198 · Cited by 1,260 · see citing works
Self-citation
Reflex control of immunity
Tracey, K. J. (2009) · Nature Reviews Immunology · doi:10.1038/nri2566 · Cited by 1,154 · see citing works
“Acetylcholine, the principal parasympathetic neurotransmitter, interacts with the G protein-coupled muscarinic acetylcholine receptors M1–M5 and nicotinic ligand-gated ion channels (termed neuronal type I–III and muscle type IV”
Background
<scp>N</scp> icotine and the adolescent brain
Yuan, M., Cross, S. J., Loughlin, S. E., & Leslie, F. M. (2015) · The Journal of Physiology · doi:10.1113/jp270492 · Cited by 582 · see citing works
Structural and functional diversity of native brain neuronal nicotinic receptors
Gotti, C., Clementi, F., Fornari, A., Gaimarri, A., Guiducci, S., Manfredi, I., Moretti, M., Pedrazzi, P., Pucci, L., & Zoli, M. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.05.024 · Cited by 469 · see citing works
Cellular diversity in the Drosophila midbrain revealed by single-cell transcriptomics
Croset, V., Treiber, C. D., & Waddell, S. (2018) · eLife · doi:10.7554/elife.34550 · Cited by 299 · see citing works
Nicotine-induced upregulation of nicotinic receptors: Underlying mechanisms and relevance to nicotine addiction
Govind, A. P., Vezina, P., & Green, W. N. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.06.011 · Cited by 338 · see citing works
Nicotine and the Developing Human
England, L. J., Bunnell, R. E., Pechacek, T. F., Tong, V. T., & McAfee, T. A. (2015) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2015.01.015 · Cited by 320 · see citing works
Neuronal nicotinic acetylcholine receptor structure and function and response to nicotine
Dani, J. A. (2015) · International Review of Neurobiology · doi:10.1016/bs.irn.2015.07.001 · Cited by 309 · see citing works
Diversity of native nicotinic receptor subtypes in mammalian brain
Zoli, M., Pistillo, F., & Gotti, C. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.11.003 · Cited by 277 · see citing works
Nicotine up-regulates α4β2 nicotinic receptors and ER exit sites via stoichiometry-dependent chaperoning
Srinivasan, R., Pantoja, R., Moss, F. J., Mackey, E. D. W., Son, C. D., Miwa, J., & Lester, H. A. (2011) · Journal of General Physiology · doi:10.1085/jgp.201010532 · Cited by 169 · see citing works
The Nicotinic Acetylcholine Receptor 5 Subunit Plays a Key Role in Attention Circuitry and Accuracy
Bailey, C. D. C., De Biasi, M., Fletcher, P. J., & Lambe, E. K. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.2258-10.2010 · Cited by 146 · see citing works
Mechanisms of Action and Persistent Neuroplasticity by Drugs of Abuse
Korpi, E. R., den Hollander, B., Farooq, U., Vashchinkina, E., Rajkumar, R., Nutt, D. J., Hyytiä, P., & Dawe, G. S. (2015) · Pharmacological Reviews · doi:10.1124/pr.115.010967 · Cited by 148 · see citing works
Importance of the nicotinic acetylcholine receptor system in the prefrontal cortex
Wallace, T. L., & Bertrand, D. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.04.001 · Cited by 133 · see citing works
The keystone of Alzheimer pathogenesis might be sought in Aβ physiology
Puzzo, D., Gulisano, W., Arancio, O., & Palmeri, A. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.08.039 · Cited by 116 · see citing works
Mecamylamine - a nicotinic acetylcholine receptor antagonist with potential for the treatment of neuropsychiatric disorders
Bacher, I., Wu, B., Shytle, D. R., & George, T. P. (2009) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656560903329102 · Cited by 96 · see citing works
Nerve Terminal Nicotinic Acetylcholine Receptors Initiate Quantal GABA Release from Perisomatic Interneurons by Activating Axonal T-Type (Cav3) Ca2+Channels and Ca2+Release from Stores
Tang, A.-H., Karson, M. A., Nagode, D. A., McIntosh, J. M., Uebele, V. N., Renger, J. J., Klugmann, M., Milner, T. A., & Alger, B. E. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.2781-11.2011 · Cited by 92 · see citing works
α 7 -Containing nicotinic acetylcholine receptors on interneurons of the basolateral amygdala and their role in the regulation of the network excitability
Pidoplichko, V. I., Prager, E. M., Aroniadou-Anderjaska, V., & Braga, M. F. M. (2013) · Journal of Neurophysiology · doi:10.1152/jn.01030.2012 · Cited by 90 · see citing works
Structure-function of neuronal nicotinic acetylcholine receptor inhibitors derived from natural toxins
Ho, T. N. T., Abraham, N., & Lewis, R. J. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.609005 · Cited by 87 · see citing works
Nicotine aversion is mediated by GABAergic interpeduncular nucleus inputs to laterodorsal tegmentum
Wolfman, S. L., Gill, D. F., Bogdanic, F., Long, K., Al-Hasani, R., McCall, J. G., Bruchas, M. R., & McGehee, D. S. (2018) · Nature Communications · doi:10.1038/s41467-018-04654-2 · Cited by 81 · see citing works
Nicotinic receptor-mediated reduction in l-DOPA-induced dyskinesias may occur via desensitization
Bordia, T., Campos, C., McIntosh, J. M., & Quik, M. (2010) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.109.162396 · Cited by 82 · see citing works
Nicotinic mechanisms influencing synaptic plasticity in the hippocampus
Placzek, A. N., Zhang, T. A., & Dani, J. A. (2009) · Acta Pharmacologica Sinica · doi:10.1038/aps.2009.39 · Cited by 77 · see citing works
Mechanistic insights into nicotine withdrawal
Paolini, M., & De Biasi, M. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.07.075 · Cited by 66 · see citing works
“Many neurotransmitters and neuropeptides are involved in the process, as nAChRs are strategically positioned to modulate the release of virtually every major neurotransmitter [8,19,20].”
Addiction‐related neuroadaptations following chronic nicotine exposure
Wills, L., & Kenny, P. J. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15356 · Cited by 61 · see citing works
Age-dependent Effects of Tobacco Smoke and Nicotine on Cognition and the Brain: A Systematic Review of the Human and Animal Literature Comparing Adolescents and Adults.
Colyer-Patel, K., Kuhns, L., Weidema, A., Lesscher, H., & Cousijn, J. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105038 · Cited by 54 · see citing works
In Vitro Pharmacological Characterization of a Novel Selective α7 Neuronal Nicotinic Acetylcholine Receptor Agonist ABT-107
Malysz, J., Anderson, D. J., Grønlien, J. H., Ji, J., Bunnelle, W. H., Håkerud, M., Thorin-Hagene, K., Ween, H., Helfrich, R., Hu, M., et al. (2010) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.167072 · Cited by 50 · see citing works
Addictive Nicotine Alters Local Circuit Inhibition during the Induction ofIn VivoHippocampal Synaptic Potentiation
Zhang, T. A., Tang, J., Pidoplichko, V. I., & Dani, J. A. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.0458-10.2010 · Cited by 33 · see citing works
Visual hallucinations in Parkinson’s disease: spotlight on central cholinergic dysfunction
Ignatavicius, A., Matar, E., & Lewis, S. J. G. (2025) · Brain · doi:10.1093/brain/awae289 · Cited by 32 · see citing works
Sex Differences in the Nicotinic Acetylcholine Receptor System of Rodents: Impacts on Nicotine and Alcohol Reward Behaviors
Moen, J. K., & Lee, A. M. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.745783 · Cited by 30 · see citing works
Possible role of the α7 nicotinic receptors in mediating nicotine’s effect on developing lung – implications in unexplained human perinatal death
Lavezzi, A. M., Corna, M. F., Alfonsi, G., & Matturri, L. (2014) · BMC Pulmonary Medicine · doi:10.1186/1471-2466-14-11 · Cited by 25 · see citing works
Trace Eyeblink Conditioning is Impaired in α7 but not in β2 Nicotinic Acetylcholine Receptor Knockout Mice
Brown, K. L., Comalli, D. M., Biasi, M. D., & Woodruff-Pak, D. S. (2010) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2010.00166 · Cited by 24 · see citing works
Regulation of α4β2α5 nicotinic acetylcholinergic receptors in rat cerebral cortex in early and late adolescence: Sex differences in response to chronic nicotine
Hoegberg, B. G., Lomazzo, E., Lee, N. H., & Perry, D. C. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.08.015 · Cited by 17 · see citing works
Systemic Nicotine Increases Gain and Narrows Receptive Fields in A1 via Integrated Cortical and Subcortical Actions
Askew, C., Intskirveli, I., & Metherate, R. (2017) · eneuro · doi:10.1523/eneuro.0192-17.2017 · Cited by 18 · see citing works
Nicotinic receptor activation contrasts pathophysiological bursting and neurodegeneration evoked by glutamate uptake block on rat hypoglossal motoneurons
Corsini, S., Tortora, M., & Nistri, A. (2016) · The Journal of Physiology · doi:10.1113/jp272591 · Cited by 16 · see citing works
Brain nitric oxide metabolites in rats preselected for nicotine preference and intake
Keser, A., Nesil, T., Kanit, L., & Pogun, S. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.04.027 · Cited by 14 · see citing works
Repeated nicotine exposure increases the intracellular interaction between ERK‐mGluR5 in the nucleus accumbens more in adult than adolescent rats
Yang, J. H., Sohn, S., Kim, S., Kim, J., Oh, J. H., Ryu, I. S., Go, B. S., & Choe, E. S. (2021) · Addiction Biology · doi:10.1111/adb.12913 · Cited by 14 · see citing works

Ganglionic nAChRs and high‐affinity nicotinic binding sites are not equivalent
Kemp, G., & Morley, B. J. (1986) · FEBS Letters · doi:10.1016/0014-5793(86)80910-3 · Cited by 29 · see citing works
In Silico Analysis of Ethanol Binding Activity in Neuronal Nicotinic Acetylcholine Receptors
Lungidningtyas, A., & Parikesit, A. A. (2020) · Malaysian Journal of Applied Sciences · doi:10.37231/myjas.2020.5.1.243 · Cited by 2 · see citing works
The Regulation of Hippocampal Nicotinic Acetylcholine Receptors (nAChRs) After a Protracted Treatment with Selective or Nonselective nAChR Agonists
Auta, J., Longone, P., Guidotti, A., & Costa, E. (1999) · Journal of Molecular Neuroscience · doi:10.1385/jmn:13:1-2:31 · Cited by 14 · see citing works
Identification of Four Classes of Brain Nicotinic Receptors Using β2 Mutant Mice
Zoli, M., Léna, C., Picciotto, M. R., & Changeux, J. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-12-04461.1998 · Cited by 343 · see citing works
Design, Synthesis and Discovery of Picomolar Selective α4β2 Nicotinic Acetylcholine Receptor Ligands
Yenugonda, V. M., Xiao, Y., Levin, E. D., Rezvani, A. H., Tran, T. P., Al‐Muhtasib, N., Sahibzada, N., Xie, T., Wells, C., Slade, S. K., et al. (2013) · Journal of Medicinal Chemistry · doi:10.1021/jm4008455 · Cited by 17 · see citing works

Authors: Albuquerque, E. X., Pereira, E. F. R., Alkondon, M., & Rogers, S. W.
Affiliations: University of Maryland, Baltimore (US)
ORCID: Pereira, Edna F. R.
Venue: Physiological Reviews
Publisher: American Physiological Society
Published: 2009-01
Volume: 89
Issue: 1
Pages: 73-120
ISSN: 0031-9333 (ISSN-L)
1522-1210
DOI: 10.1152/physrev.00015.2008
PMC: PMC2713585
OpenAlex: W2104838343
Cited by: 1,724
References: 582
Citations by year: 2026: 49 · 2025: 68 · 2024: 85 · 2023: 89 · 2022: 87 · 2021: 101 · 2020: 116 · 2019: 121 · 2018: 126 · 2017: 96 · 2016: 103 · 2015: 131 · 2014: 113 · 2013: 116 · 2012: 102
FWCI: 8.24
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Physiological Reviews (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (AG-17517, R01AG017517)
National Heart, Lung, and Blood Institute (P01HL072903, P01-HL72903)
National Institute of Neurological Disorders and Stroke (R01NS025296, U01NS059344, NS 25296, U01-NS-59344)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
Keywords: nicotinic acetylcholine receptors, ligand-gated ion channels, muscle-type nAChR, alpha-bungarotoxin, Torpedo electric organ, nicotine, drug addiction, Alzheimer's disease, Parkinson's disease, schizophrenia, receptor structure, receptor function, non-neuronal cells
MeSH terms: Alzheimer Disease, Animals, Brain, Disease Models, Animal, Gene Expression Regulation, Humans, Parkinson Disease, Receptors, Nicotinic

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Mammalian nicotinic acetylcholine receptors: from structure to function

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks