The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Adriamycin‐mediated nitration of manganese superoxide dismutase in the central nervous system: insight into the mechanism of chemobrain
Abstract
Adriamycin (ADR), a potent anti‐tumor agent, produces reactive oxygen species (ROS) in cardiac tissue. Treatment with ADR is dose‐limited by cardiotoxicity. However, the effect of ADR in the other tissues, including the brain, is unclear because ADR does not pass the blood–brain barrier. Some cancer patients receiving ADR treatment develop a transient memory loss, inability to handle complex tasks etc., often referred to by patients as chemobrain. We previously demonstrated that ADR causes CNS toxicity, in part, via systemic release of cytokines and subsequent generation of reactive oxygen and nitrogen species (RONS) in the brain. Here, we demonstrate that treatment with ADR led to an increased circulating level of tumor necrosis factor‐alpha in wild‐type mice and in mice deficient in the inducible form of nitric oxide (iNOSKO). However, the decline in mitochondrial respiration and mitochondrial protein nitration after ADR treatment was observed only in wild‐type mice, not in the iNOSKO mice. Importantly, the activity of a major mitochondrial antioxidant enzyme, manganese superoxide dismutase (MnSOD), was reduced and the protein was nitrated. Together, these results suggest that NO is an important mediator, coupling the effect of ADR with cytokine production and subsequent activation of iNOS expression. We also identified the mitochondrion as an important target of ADR‐induced NO‐mediated CNS injury.
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Cites
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“Irreversible inhibition has been suggested to contribute to the cytotoxicity of high concentrations or long-term exposure to NO (Moncada and Higgs 1993; Radi 2004).”
BackgroundDilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase
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Murine tumor necrosis factor alpha is transported from blood to brain in the mouse
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Cytokines and the central nervous system
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“TNF-a can also be generated within the CNS, and all neuronal cell types are thought to contain TNF-receptors and be capable of synthesizing TNF-a in brain tissues (Sternberg 1997; Madrigal et al. 2002; Perry et al. 2002).”
BackgroundPathways and mechanisms for cytokine signaling of the central nervous system.
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Cited by
Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity
Calabrese, V., Mancuso, C., Calvani, M., Rizzarelli, E., Butterfield, D. A., & Giuffrida Stella, A. M. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2214 · Cited by 1,543
Self-citationPrevalence, mechanisms, and management of cancer-related cognitive impairment
Janelsins, M. C., Kesler, S. R., Ahles, T. A., & Morrow, G. R. (2014) · International Review of Psychiatry · doi:10.3109/09540261.2013.864260 · Cited by 745
Butterfield, D. A., Reed, T., Newman, S. F., & Sultana, R. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.05.037 · Cited by 564
Self-citationLipid peroxidation and neurodegenerative disease
Reed, T. T. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.06.027 · Cited by 379
Manganese Superoxide Dismutase: Guardian of the Powerhouse
Holley, A. K., Bakthavatchalu, V., Velez-Roman, J. M., & St. Clair, D. K. (2011) · International Journal of Molecular Sciences · doi:10.3390/ijms12107114 · Cited by 358
Metadata
- Authors
- Tangpong, J., Cole, M. P., Sultana, R., Estus, S., Vore, M., St. Clair, W., Ratanachaiyavong, S., St. Clair, D. K., & Butterfield, D. A.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 2006-08-21
- Volume
- 100
- Issue
- 1
- Pages
- 191-201
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W2010236853
- Cited by
- 185
- References
- 8
- FWCI
- 6.98
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Adriamycin‐mediated nitration of manganese superoxide dismutase in the central nervous system: insight into the mechanism of chemobrain. https://app.cochat.ai/papers/10.1111/j.1471-4159.2006.04179.x
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- Tangpong, J., Cole, M. P., Sultana, R., Estus, S., Vore, M., St. Clair, W., Ratanachaiyavong, S., St. Clair, D. K., & Butterfield, D. A. (2007). Adriamycin‐mediated nitration of manganese superoxide dismutase in the central nervous system: insight into the mechanism of chemobrain. Journal of Neurochemistry. https://doi.org/10.1111/j.1471-4159.2006.04179.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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