The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Ketone bodies are protective against oxidative stress in neocortical neurons
Open accessAbstract
Ketone bodies (KB) have been shown to prevent neurodegeneration in models of Parkinson’s and Alzheimer’s diseases, but the mechanisms underlying these effects remain unclear. One possibility is that KB may exert antioxidant activity. In the current study, we explored the effects of KB on rat neocortical neurons exposed to hydrogen peroxide (H 2 O 2) or diamide – a thiol oxidant and activator of mitochondrial permeability transition (mPT). We found that: (i) KB completely blocked large inward currents induced by either H 2 O 2 or diamide; (ii) KB significantly decreased the number of propidium iodide‐labeled cells in neocortical slices after exposure to H 2 O 2 or diamide; (iii) KB significantly decreased reactive oxygen species (ROS) levels in dissociated neurons and in isolated neocortical mitochondria; (iv) the electrophysiological effects of KB in neurons exposed to H 2 O 2 or diamide were mimicked by bongkrekic acid and cyclosporin A, known inhibitors of mPT, as well as by catalase and DL – dithiothreitol, known antioxidants; (v) diamide alone did not significantly alter basal ROS levels in neurons, supporting previous studies indicating that diamide‐induced neuronal injury may be mediated by mPT opening; and (vi) KB significantly increased the threshold for calcium‐induced mPT in isolated mitochondria. Taken together, our data suggest that KB may prevent mPT and oxidative injury in neocortical neurons, most likely by decreasing mitochondrial ROS production.
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Citations
Cites
Reactive Oxygen Species and the Central Nervous System
Halliwell, B. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb10990.x · Cited by 2,947
Nakagawa, T., Shimizu, S., Watanabe, T., Yamaguchi, O., Otsu, K., Yamagata, H., Inohara, H., Kubo, T., & Tsujimoto, Y. (2005) · Nature · doi:10.1038/nature03317 · Cited by 1,635 · cited 1×
“Given these findings, it is possible that KB may interact with the mPT complex itself (Costantini et al. 2000; Clarke et al. 2002; Nakagawa et al. 2005).”
BackgroundOxidative Stress in Neurodegenerative Diseases
Simonian, N. A., & Coyle, J. T. (1996) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.36.040196.000503 · Cited by 1,377
Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS
Nisoli, E., Tonello, C., Cardile, A., Cozzi, V., Bracale, R., Tedesco, L., Falcone, S., Valerio, A., Cantoni, O., Clementi, E., et al. (2005) · Science · doi:10.1126/science.1117728 · Cited by 1,107 · cited 1×
“On the other hand, such effects may be mediated not by antioxidant activity, but by enhancement of nitric oxide levels (Nisoli et al. 2005).”
BackgroundD-β-Hydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson disease
Tieu, K., Perier, C., Caspersen, C., Teismann, P., Wu, D.-C., Yan, S.-D., Naini, A., Vila, M., Jackson-Lewis, V., Ramasamy, R., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200318797 · Cited by 497
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Cited by
Suppression of Oxidative Stress by β-Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor
Shimazu, T., Hirschey, M. D., Newman, J., He, W., Shirakawa, K., Le Moan, N., Grueter, C. A., Lim, H., Saunders, L. R., Stevens, R. D., et al. (2013) · Science · doi:10.1126/science.1227166 · Cited by 1,777
ATM Activation by Oxidative Stress
Guo, Z., Kozlov, S., Lavin, M. F., Person, M. D., & Paull, T. T. (2010) · Science · doi:10.1126/science.1192912 · Cited by 1,079
Mitochondrial Energetics and Therapeutics
Wallace, D. C., Fan, W., & Procaccio, V. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathol.4.110807.092314 · Cited by 730
The Ketogenic Diet as a Treatment Paradigm for Diverse Neurological Disorders
Stafstrom, C. E., & Rho, J. M. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00059 · Cited by 438
Self-citationAn evolutionary perspective on immunometabolism
Wang, A., Luan, H. H., & Medzhitov, R. (2019) · Science · doi:10.1126/science.aar3932 · Cited by 389
Metadata
- Authors
- Kim, D. Y., Davis, L. M., Sullivan, P. G., Maalouf, M., Simeone, T. A., Brederode, J. V., & Rho, J. M.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 2007-02-20
- Volume
- 101
- Issue
- 5
- Pages
- 1316-1326
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W2088700698
- Cited by
- 205
- References
- 7
- FWCI
- 2.51
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Kim, D. Y., Davis, L. M., Sullivan, P. G., Maalouf, M., Simeone, T. A., Brederode, J. V., & Rho, J. M. (2007). Ketone bodies are protective against oxidative stress in neocortical neurons. Journal of Neurochemistry. https://doi.org/10.1111/j.1471-4159.2007.04483.x
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