ATM Activation by Oxidative Stress

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

Rogakou, E. P., Pilch, D. R., Orr, A. H., Ivanova, V. S., & Bonner, W. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.10.5858 · Cited by 5,438 · see citing works

Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple

Schafer, F. Q., & Buettner, G. R. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00480-4 · Cited by 4,587 · see citing works

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

Bakkenist, C. J., & Kastan, M. B. (2003) · Nature · doi:10.1038/nature01368 · Cited by 3,466 · see citing works

Reactive oxygen species, cellular redox systems, and apoptosis

Circu, M. L., & Aw, T. Y. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.12.022 · Cited by 3,340 · see citing works

ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage

Matsuoka, S., Ballif, B. A., Smogorzewska, A., McDonald, E. R., Hurov, K. E., Luo, J., Bakalarski, C. E., Zhao, Z., Solimini, N., Lerenthal, Y., et al. (2007) · Science · doi:10.1126/science.1140321 · Cited by 3,075 · see citing works

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

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A Single Ataxia Telangiectasia Gene with a Product Similar to PI-3 Kinase

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ATM and related protein kinases: safeguarding genome integrity

Shiloh, Y. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1011 · Cited by 2,577 · see citing works

A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

Paull, T. T., Rogakou, E. P., Yamazaki, V., Kirchgessner, C. U., Gellert, M., & Bonner, W. M. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00610-2 · Cited by 2,098 · see citing works

Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53

Canman, C. E., Lim, D.-S., Cimprich, K. A., Taya, Y., Tamai, K., Sakaguchi, K., Appella, E., Kastan, M. B., & Siliciano, J. D. (1998) · Science · doi:10.1126/science.281.5383.1677 · Cited by 2,042 · see citing works

DNA damage and oxygen radical toxicity

Imlay, J. A., & Linn, S. (1988) · Science · doi:10.1126/science.3287616 · Cited by 1,974 · see citing works

Oxidized Redox State of Glutathione in the Endoplasmic Reticulum

Hwang, C., Sinskey, A. J., & Lodish, H. F. (1992) · Science · doi:10.1126/science.1523409 · Cited by 1,968 · see citing works

Cell cycle checkpoint signaling through the ATM and ATR kinases

Abraham, R. T. (2001) · Genes & Development · doi:10.1101/gad.914401 · Cited by 1,966 · see citing works

Enhanced Phosphorylation of p53 by ATM in Response to DNA Damage

Banin, S., Moyal, L., Shieh, S.-Y., Taya, Y., Anderson, C. W., Chessa, L., Smorodinsky, N. I., Prives, C., Reiss, Y., Shiloh, Y., et al. (1998) · Science · doi:10.1126/science.281.5383.1674 · Cited by 1,797 · see citing works

The p66shc adaptor protein controls oxidative stress response and life span in mammals

Migliaccio, E., Giorgio, M., Mele, S., Pelicci, G., Reboldi, P., Pandolfi, P. P., Lanfrancone, L., & Pelicci, P. G. (1999) · Nature · doi:10.1038/46311 · Cited by 1,712 · see citing works

Hydrogen peroxide sensing and signaling

Veal, E. A., Day, A. M., & Morgan, B. A. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.03.016 · Cited by 1,604 · see citing works

NF-κB activation by reactive oxygen species: Fifteen years later

Gloire, G., Legrand-Poels, S., & Piette, J. G. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.04.011 · Cited by 1,540 · see citing works

ATM Activation by DNA Double-Strand Breaks Through the Mre11-Rad50-Nbs1 Complex

Lee, J.-H., & Paull, T. T. (2005) · Science · doi:10.1126/science.1108297 · Cited by 1,424 · see citing works

Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells

Ito, K., Hirao, A., Arai, F., Takubo, K., Matsuoka, S., Miyamoto, K., Ohmura, M., Naka, K., Hosokawa, K., Ikeda, Y., et al. (2006) · Nature Medicine · doi:10.1038/nm1388 · Cited by 1,362 · see citing works

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

Falck, J., Coates, J., & Jackson, S. P. (2005) · Nature · doi:10.1038/nature03442 · Cited by 1,248 · see citing works

The hMre11/hRad50 Protein Complex and Nijmegen Breakage Syndrome: Linkage of Double-Strand Break Repair to the Cellular DNA Damage Response

Carney, J. P., Maser, R. S., Olivares, H., Davis, E. M., Le Beau, M., Yates, J. R., Hays, L., Morgan, W. F., & Petrini, J. H. J. (1998) · Cell · doi:10.1016/s0092-8674(00)81175-7 · Cited by 1,226 · see citing works

Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells

Ito, K., Hirao, A., Arai, F., Matsuoka, S., Takubo, K., Hamaguchi, I., Nomiyama, K., Hosokawa, K., Sakurada, K., Nakagata, N., et al. (2004) · Nature · doi:10.1038/nature02989 · Cited by 1,175 · cited 1× · see citing works

Redox Regulation of Cellular Signalling

Kamata, H., & Hirata, H. (1999) · Cellular Signalling · doi:10.1016/s0898-6568(98)00037-0 · Cited by 1,150 · see citing works

MDC1 Directly Binds Phosphorylated Histone H2AX to Regulate Cellular Responses to DNA Double-Strand Breaks

Stucki, M., Clapperton, J. A., Mohammad, D. H., Yaffe, M. B., Smerdon, S. J., & Jackson, S. P. (2005) · Cell · doi:10.1016/j.cell.2005.09.038 · Cited by 1,103 · see citing works

Requirement of the MRN complex for ATM activation by DNA damage

Uziel, T., Lerenthal, Y., Moyal, L., Andegeko, Y., Mittelman, L., & Shiloh, Y. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg541 · Cited by 1,075 · see citing works

The DNA Double-Strand Break Repair Gene hMRE11 Is Mutated in Individuals with an Ataxia-Telangiectasia-like Disorder

Stewart, G. S., Maser, R. S., Stankovic, T., Bressan, D. A., Kaplan, M. I., Jaspers, N. G. J., Raams, A., Byrd, P. J., Petrini, J. H. J., & Taylor, A. M. R. (1999) · Cell · doi:10.1016/s0092-8674(00)81547-0 · Cited by 1,060 · see citing works

Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer

Lavin, M. F. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2514 · Cited by 901 · see citing works

Orchestration of the DNA-Damage Response by the RNF8 Ubiquitin Ligase

Kolas, N. K., Chapman, J. R., Nakada, S., Ylanko, J., Chahwan, R., Sweeney, F. D., Panier, S., Mendez, M., Wildenhain, J., Thomson, T. M., et al. (2007) · Science · doi:10.1126/science.1150034 · Cited by 900 · see citing works

Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1

Denchi, E. L., & de Lange, T. (2007) · Nature · doi:10.1038/nature06065 · Cited by 880 · see citing works

ATM Signaling Facilitates Repair of DNA Double-Strand Breaks Associated with Heterochromatin

Goodarzi, A. A., Noon, A. T., Deckbar, D., Ziv, Y., Shiloh, Y., Löbrich, M., & Jeggo, P. A. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.05.017 · Cited by 836 · see citing works

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

Matsuoka, S., Rotman, G., Ogawa, A., Shiloh, Y., Tamai, K., & Elledge, S. J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.190030497 · Cited by 830 · see citing works

Redox Regulation of Forkhead Proteins Through a <i>p66shc</i> -Dependent Signaling Pathway

Nemoto, S., & Finkel, T. (2002) · Science · doi:10.1126/science.1069004 · Cited by 818 · see citing works

FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK

Essers, M. A., Weijzen, S., de Vries‐Smits, A. M., Saarloos, I., de Ruiter, N. D., Bos, J. L., & Burgering, B. M. T. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600476 · Cited by 798 · see citing works

DNA damage responses to oxidative stress

Barzilai, A., & Yamamoto, K.-I. (2004) · DNA Repair · doi:10.1016/j.dnarep.2004.03.002 · Cited by 796 · see citing works

Direct Activation of the ATM Protein Kinase by the Mre11/Rad50/Nbs1 Complex

Lee, J.-H., & Paull, T. T. (2004) · Science · doi:10.1126/science.1091496 · Cited by 762 · see citing works

Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway

Ziv, Y., Bielopolski, D., Galanty, Y., Lukas, C., Taya, Y., Schultz, D. C., Lukas, J., Bekker-Jensen, S., Bartek, J., & Shiloh, Y. (2006) · Nature Cell Biology · doi:10.1038/ncb1446 · Cited by 735 · see citing works

Systematic Discovery of In Vivo Phosphorylation Networks

Linding, R., Jensen, L. J., Ostheimer, G. J., van Vugt, M. A. T. M., Jørgensen, C., Miron, I. M., Diella, F., Colwill, K., Taylor, L., Elder, K., et al. (2007) · Cell · doi:10.1016/j.cell.2007.05.052 · Cited by 735 · see citing works

Base excision repair of oxidative DNA damage and association with cancer and aging

Maynard, S., Schurman, S. H., Harboe, C., de Souza-Pinto, N. C., & Bohr, V. A. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn250 · Cited by 685 · see citing works

DNA end-joining: from yeast to man

Critchlow, S. E., & Jackson, S. P. (1998) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(98)01284-5 · Cited by 584 · see citing works

Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damagePreprint

Kim, S., Xu, B., & Kastan, M. B. (2002) · Genes & Development · doi:10.1101/gad.970602 · Cited by 581 · see citing works

Mammalian G1- and S-phase checkpoints in response to DNA damage

Bártek, J., & Lukas, J. (2001) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00280-5 · Cited by 573 · see citing works

Phosphorylation of SMC1 is a critical downstream event in the ATM–NBS1–BRCA1 pathwayPreprint

Kitagawa, R., Bakkenist, C. J., McKinnon, P. J., & Kastan, M. B. (2004) · Genes & Development · doi:10.1101/gad.1200304 · Cited by 528 · see citing works

Adenovirus oncoproteins inactivate the Mre11–Rad50–NBS1 DNA repair complex

Stracker, T. H., Carson, C. T., & Weitzman, M. D. (2002) · Nature · doi:10.1038/nature00863 · Cited by 522 · see citing works

Molecular Linkage Between the Kinase ATM and NF-κB Signaling in Response to Genotoxic Stimuli

Wu, Z., Shi, Y., Tibbetts, R. S., & Miyamoto, S. (2006) · Science · doi:10.1126/science.1121513 · Cited by 515 · see citing works

Gene expression and the thiol redox state

Arrigo, A. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00175-6 · Cited by 511 · see citing works

DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme?

Durocher, D., & Jackson, S. P. (2001) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00201-5 · Cited by 506 · see citing works

SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpointPreprint

Yazdi, P. T., Wang, Y., Zhao, S., Patel, N., Lee, E. Y.-H. P., & Qin, J. (2002) · Genes & Development · doi:10.1101/gad.970702 · Cited by 505 · see citing works

hMre11 and hRad50 Nuclear Foci Are Induced During the Normal Cellular Response to DNA Double-Strand Breaks †

Maser, R. S., Monsen, K. J., Nelms, B. E., & Petrini, J. H. J. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.10.6087 · Cited by 499 · see citing works

Cysteine Redox Sensor in PKGIa Enables Oxidant-Induced Activation

Burgoyne, J. R., Madhani, M., Cuello, F., Charles, R. L., Brennan, J. P., Schröder, E., Browning, D. D., & Eaton, P. (2007) · Science · doi:10.1126/science.1144318 · Cited by 457 · see citing works

PI 3-kinase related kinases: ?big? players in stress-induced signaling pathways

Abraham, R. T. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.04.002 · Cited by 445 · see citing works

A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis

Trinei, M., Giorgio, M., Cicalese, A., Barozzi, S., Ventura, A., Migliaccio, E., Milia, E., Padura, I. M., Raker, V. A., Maccarana, M., et al. (2002) · Oncogene · doi:10.1038/sj.onc.1205513 · Cited by 436 · see citing works

ATM stabilizes DNA double-strand-break complexes during V(D)J recombination

Bredemeyer, A. L., Sharma, G. G., Huang, C., Helmink, B. A., Walker, L. M., Khor, K. C., Nuskey, B., Sullivan, K. E., Pandita, T. K., Bassing, C. H., et al. (2006) · Nature · doi:10.1038/nature04866 · Cited by 425 · see citing works

The life and death of DNA-PK

Collis, S. J., DeWeese, T. L., Jeggo, P. A., & Parker, A. R. (2004) · Oncogene · doi:10.1038/sj.onc.1208332 · Cited by 417 · see citing works

Ca2+- and phospholipid-independent activation of protein kinase C by selective oxidative modification of the regulatory domain.

Gopalakrishna, R., & Anderson, W. B. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.17.6758 · Cited by 409 · see citing works

Chk2 kinase — a busy messenger

Bártek, J., Falck, J., & Lukas, J. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35103059 · Cited by 400 · see citing works

Mdc1 couples DNA double‐strand break recognition by Nbs1 with its H2AX‐dependent chromatin retention

Lukas, C., Melander, F., Stucki, M., Falck, J., Bekker‐Jensen, S., Goldberg, M., Lerenthal, Y., Jackson, S. P., Bártek, J., & Lukas, J. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600269 · Cited by 387 · see citing works

TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene

Greenwell, P. W., Kronmal, S., Porter, S. E., Gassenhuber, J., Obermaier, B., & Petes, T. D. (1995) · Cell · doi:10.1016/0092-8674(95)90479-4 · Cited by 385 · see citing works

ATM deficiency and oxidative stress: a new dimension of defective response to DNA damage

Barzilai, A. (2002) · DNA Repair · doi:10.1016/s1568-7864(01)00007-6 · Cited by 359 · see citing works

Redox Signaling and the Emerging Therapeutic Potential of Thiol Antioxidants

Sen, C. K. (1998) · Biochemical Pharmacology · doi:10.1016/s0006-2952(97)00672-2 · Cited by 358 · see citing works

Oxidative stress in environmental-induced carcinogenesis

Mena, S., Ortega, Á., & Estrela, J. M. (2008) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2008.09.017 · Cited by 356 · see citing works

[11] Diamide: An oxidant probe for thiols

Kosower, N. S., & Kosower, E. M. (1995) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(95)51116-4 · Cited by 340 · see citing works

MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways

Lou, Z., Minter‐Dykhouse, K., Wu, X., & Chen, J. (2003) · Nature · doi:10.1038/nature01447 · Cited by 328 · see citing works

DNA Damage-Induced Acetylation of Lysine 3016 of ATM Activates ATM Kinase Activity

Sun, Y., Xu, Y., Roy, K., & Price, B. D. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01382-07 · Cited by 319 · see citing works

Apoptosis induced by exposure to a low steady-state concentration of H2O2 is a consequence of lysosomal rupture

Antunes, F., Cadenas, E., & Brunk, U. T. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3560549 · Cited by 286 · see citing works

Involvement of novel autophosphorylation sites in ATM activation

Kozlov, S., Graham, M. E., Peng, C., Chen, P., Robinson, P. J., & Lavin, M. F. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601231 · Cited by 283 · see citing works

Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1

Yang, D., & Kastan, M. B. (2000) · Nature Cell Biology · doi:10.1038/35046542 · Cited by 278 · see citing works

Oxidative influence on development and differentiation: An overview of a free radical theory of development

Allen, R. G., & Balin, A. K. (1989) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(89)90071-3 · Cited by 270 · see citing works

Full Activation of PKB/Akt in Response to Insulin or Ionizing Radiation Is Mediated through ATM

Viniegra, J. G., Martínez, N., Modirassari, P., Hernández‐Losa, J., Cobo, C. P., Lobo, V. J. S.-A., Luquero, C. I. A., Álvarez‐Vallina, L., y Cajal, S. R., Rojas, J. M., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m410344200 · Cited by 270 · see citing works

Autophosphorylation of ataxia‐telangiectasia mutated is regulated by protein phosphatase 2A

Goodarzi, A. A., Jonnalagadda, J. C., Douglas, P., Young, D., Ye, R., Moorhead, G. B. G., Lees‐Miller, S. P., & Khanna, K. K. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600455 · Cited by 269 · see citing works

Genotype-Phenotype Relationships in Ataxia-Telangiectasia and Variants

Gilad, S., Chessa, L., Khosravi, R., Russell, P. S., Galanty, Y., Piane, M., Gatti, R. A., Jorgensen, T. J., Shiloh, Y., & Bar‐Shira, A. (1998) · The American Journal of Human Genetics · doi:10.1086/301755 · Cited by 253 · see citing works

Doxorubicin Activates ATM-dependent Phosphorylation of Multiple Downstream Targets in Part through the Generation of Reactive Oxygen Species

Kurz, E. U., Douglas, P., & Lees‐Miller, S. P. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406879200 · Cited by 251 · see citing works

Foxo3 Is Essential for the Regulation of Ataxia Telangiectasia Mutated and Oxidative Stress-mediated Homeostasis of Hematopoietic Stem Cells

Yalcin, S., Zhang, X., Luciano, J. P., Mungamuri, S. K., Marinkovic, D., Vercherat, C., Sarkar, A., Grisotto, M., Taneja, R., & Ghaffari, S. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800517200 · Cited by 247 · see citing works

Cellular titration of apoptosis with steady state concentrations of H2O2: submicromolar levels of H2O2 induce apoptosis through fenton chemistry independent of the cellular thiol state

Antunes, F., & Cadenas, E. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00493-2 · Cited by 247 · see citing works

ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome

Schneider, J. G., Finck, B. N., Ren, J., Standley, K. N., Takagi, M., Maclean, K. H., Bernal‐Mizrachi, C., Muslin, A. J., Kastan, M. B., & Semenkovich, C. F. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.10.002 · Cited by 235 · see citing works

Two-step activation of ATM by DNA and the Mre11–Rad50–Nbs1 complex

Dupré, A., Boyer-Châtenet, L., & Gautier, J. (2006) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1090 · Cited by 233 · see citing works

The mRNA Surveillance Protein hSMG-1 Functions in Genotoxic Stress Response Pathways in Mammalian Cells

Brumbaugh, K. M., Otterness, D. M., Geisen, C., Oliveira, V. A., Brognard, J., Li, X., Lejeune, F., Tibbetts, R. S., Maquat, L. E., & Abraham, R. T. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.05.005 · Cited by 222 · see citing works

Demonstration of nuclear compartmentalization of glutathione in hepatocytes.

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An alternative mode of translation permits production of a variant NBS1 protein from the common Nijmegen breakage syndrome allele

Maser, R. S., Zinkel, R. A., & Petrini, J. H. J. (2001) · Nature Genetics · doi:10.1038/86920 · Cited by 217 · see citing works

Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo

Pellegrini, M., Celeste, A., Difilippantonio, S., Guo, R., Wang, W., Feigenbaum, L., & Nussenzweig, A. (2006) · Nature · doi:10.1038/nature05112 · Cited by 207 · see citing works

Ketone bodies are protective against oxidative stress in neocortical neurons

‍Kim, D. Y., Davis, L. M., Sullivan, P. G., Maalouf, M., Simeone, T. A., van Brederode, J. F. M., & Rho, J. M. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04483.x · Cited by 205 · see citing works

ATM Activation and Signaling under Hypoxic Conditions

Bencokova, Z., Kaufmann, M. R., Pires, I. M., Lecane, P. S., Giaccia, A. J., & Hammond, E. M. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01301-08 · Cited by 205 · see citing works

Functional interaction between FOXO3a and ATM regulates DNA damage response

Tsai, W.-B., Chung, Y. M., Takahashi, Y. K., Xu, Z., & Hu, M. C. ‐. (2008) · Nature Cell Biology · doi:10.1038/ncb1709 · Cited by 204 · see citing works

Cardiac transport of glutathione disulfide and S-conjugate. Studies with isolated perfused rat heart during hydroperoxide metabolism.

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Essential Role for DNA-PKcs in DNA Double-Strand Break Repair and Apoptosis in ATM-Deficient Lymphocytes

Callén, E., Janković, M., Wong, N., Zha, S., Chen, H.-T., Difilippantonio, S., Virgilio, M. D., Heidkamp, G. F., Alt, F. W., Nussenzweig, A., et al. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.04.025 · Cited by 198 · see citing works

Cancer Risk and the ATM Gene: a Continuing Debate

Khanna, K. K. (2000) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/92.10.795 · Cited by 198 · see citing works

Syndromal and nonsyndromal primary trigonocephaly: Analysis of a series of 237 patients

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Radiosensitivity in Ataxia-telangiectasia: Anomalies in Radiation-induced Cell Cycle Delay

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Localization of a Portion of Extranuclear ATM to Peroxisomes

Watters, D. J., Kedar, P. S., Spring, K. J., Björkman, J., Chen, P., Gatei, M. H., Birrell, G. W., Garrone, B., Srinivasa, P., Crane, D. I., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.48.34277 · Cited by 190 · see citing works

Genomic instability and cancer

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ATM binds to β-adaptin in cytoplasmic vesicles

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Purification and DNA binding properties of the ataxia-telangiectasia gene product ATM

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A Proteomic Analysis of Ataxia Telangiectasia-mutated (ATM)/ATM-Rad3-related (ATR) Substrates Identifies the Ubiquitin-Proteasome System as a Regulator for DNA Damage Checkpoints

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Immunoglobulin Class Switch Recombination Is Impaired in Atm-deficient Mice

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Requirement of protein phosphatase 5 in DNA-damage-induced ATM activationPreprint

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ATM is a cytoplasmic protein in mouse brain required to prevent lysosomal accumulation

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Identification of CDK2 substrates in human cell lysates

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Integrating stress-response and cell-cycle checkpoint pathways

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Thioltransferase (Glutaredoxin) Reactivates the DNA-binding Activity of Oxidation-inactivated Nuclear Factor I

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A novel methodology for assignment of disulfide bond pairings in proteins

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Complexities of the DNA base excision repair pathway for repair of oxidative DNA damage

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Loss of ATM Impairs Proliferation of Neural Stem Cells Through Oxidative Stress-Mediated p38 MAPK Signaling

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Activation of ATM depends on chromatin interactions occurring before induction of DNA damage

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Oxidative stress-related aging: A role for prostate cancer?

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Mre11–Rad50–Nbs1‐dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity

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The Solution Structure of the FATC Domain of the Protein Kinase Target of Rapamycin Suggests a Role for Redox-dependent Structural and Cellular Stability

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The Ataxia telangiectasia Gene Product Is Required for Oxidative Stress-induced G1 and G2Checkpoint Function in Human Fibroblasts

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Purification and Characterization of ATM from Human Placenta

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Multistep Disulfide Bond Formation in Yap1 Is Required for Sensing and Transduction of H2O2 Stress Signal

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Accumulation of DNA Damage and Reduced Levels of Nicotine Adenine Dinucleotide in the Brains of Atm-deficient Mice

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Activation of Ataxia Telangiectasia Mutated by DNA Strand Break-inducing Agents Correlates Closely with the Number of DNA Double Strand Breaks

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Rapid activation of ATM on DNA flanking double-strand breaks

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Activation of p53 by Oxidative Stress Involves Platelet-derived Growth Factor-β Receptor-mediated Ataxia Telangiectasia Mutated (ATM) Kinase Activation

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Proinflammatory cytokine-induced cellular senescence of biliary epithelial cells is mediated via oxidative stress and activation of ATM pathway: A culture study

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Drosophila ATM and ATR checkpoint kinases control partially redundant pathways for telomere maintenance

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ATM deficiency induces oxidative stress and endoplasmic reticulum stress in astrocytes

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NF-κB activation by combinations of NEMO SUMOylation and ATM activation stresses in the absence of DNA damage

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Saccharomyces cerevisiae ATM orthologue suppresses break-induced chromosome translocations

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Induction of ATF3 by ionizing radiation is mediated via a signaling pathway that includes ATM, Nibrin1, stress-induced MAPkinases and ATF-2

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Low-Level Oxidative Stress Causes Cell Cycle-Specific Arrest in Cultured Cells

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Oxidative stress-induced apoptosis in dividing fibroblasts involves activation of p38 MAP kinase and over-expression of Bax: Resistance of quiescent cells to oxidative stress

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Cytometric assessment of DNA damage by exogenous and endogenous oxidants reports aging‐related processes

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DNA Damage-induced Association of ATM with Its Target Proteins Requires a Protein Interaction Domain in the N Terminus of ATM

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ATM deficiency impairs thymocyte maturation because of defective resolution of T cell receptor α locus coding end breaks

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Role of ATM in Oxidative Stress-mediated c-Jun Phosphorylation in Response to Ionizing Radiation and CdCl2

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Heterogeneity in ataxia‐telangiectasia: Classical phenotype associated with intermediate cellular radiosensitivity

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hSMG-1 and ATM sequentially and independently regulate the G1 checkpoint during oxidative stress

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Activation of ATM signaling pathway is involved in oxidative stress-induced expression of mito-inhibitory p21WAF1/Cip1 in chronic non-suppurative destructive cholangitis in primary biliary cirrhosis: An immunohistochemical study

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Antioxidants Suppress Lymphoma and Increase Longevity in Atm-Deficient Mice ,3

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Electron microscopy and 3D reconstructions reveal that human ATM kinase uses an arm-like domain to clamp around double-stranded DNA

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A Combination of Genomic Approaches Reveals the Role of FOXO1a in Regulating an Oxidative Stress Response Pathway

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Kinetic analysis of the Ku-DNA binding activity reveals a redox-dependent alteration in protein structure that stimulates dissociation of the Ku-DNA complex

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Induction of oxidative stress and inhibition of plasminogen activator inhibitor-1 production in endothelial cells following exposure to organic extracts of diesel exhaust particles and urban fine particles

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ATM-mediated response to DNA double strand breaks in human neurons derived from stem cells

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Oxidative stress induces cell cycle-dependent Mre11 recruitment, ATM and Chk2 activation and histone H2AX phosphorylation

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The Hog1 MAP kinase pathway and the Mec1 DNA damage checkpoint pathway independently control the cellular responses to hydrogen peroxide

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Purification and Biochemical Characterization of Ataxia‐Telangiectasia Mutated and Mre11/Rad50/Nbs1

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Effects of antioxidants on cancer prevention and neuromotor performance in Atm deficient mice

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Pro- or anti-oxidant manganese: a suggested mechanism for reconciliation

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Possible involvement of p21/waf1 in the growth inhibition of HepG2 cells induced by hepatocyte growth factor

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Chk2 kinase is required for methylglyoxal‐induced G2/M cell‐cycle checkpoint arrest: implication of cell‐cycle checkpoint regulation in diabetic oxidative stress signaling

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ATM activation by a sulfhydryl‐reactive inflammatory cyclopentenone prostaglandin

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ATM's leucine-rich domain and adjacent sequences are essential for ATM to regulate the DNA damage response

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Expression and Assay of Recombinant ATM

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Induction and control of oxidative stress

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Redox-Dependent Dynamics of a Dual Thioredoxin Fold Protein: Evolution of Specialized Folds

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Redox Regulation and Trapping Sulphenic Acid in the Peroxide Sensitive Human Mitochondrial Branched Chain Aminotransferase

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Radiosensitization of Mammalian Cells by Diamide

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Mutations of the human MUT S homologue 6 gene in ampullary carcinoma and gastric cancer

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ROS function in redox signaling and oxidative stress

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Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

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Modulation of oxidative stress as an anticancer strategy

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Ageing as a risk factor for neurodegenerative disease

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Signal transduction by reactive oxygen species

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ROS in cancer therapy: the bright side of the moon

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The ATM protein kinase: regulating the cellular response to genotoxic stress, and more

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Beyond oxidative stress: an immunologist's guide to reactive oxygen species

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DNA Damage Sensing by the ATM and ATR Kinases

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From NASH to HCC: current concepts and future challenges

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Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche

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NAD + Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair

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Immunological impact of cell death signaling driven by radiation on the tumor microenvironment

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Mitochondrial dysfunction in ataxia-telangiectasia

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Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: the molecular choreography

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ATR signalling: more than meeting at the fork

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Redox regulation of protein kinases

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Chemotherapy induced DNA damage response: Convergence of drugs and pathways

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Oxidative Stress Responses in the Human Fungal Pathogen, Candida albicans

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DNA damage response and metabolic disease

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Restoring oxidant signaling suppresses proarthritogenic T cell effector functions in rheumatoid arthritis

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A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS

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Nuclear initiated NF-κB signaling: nemo and ATM take center stage

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Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress

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Redox control of skeletal muscle atrophy.

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Oxidative stress induces an ATM‐independent senescence pathway through p38 MAPK‐mediated lamin B1 accumulation

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Pathogenesis of ataxia-telangiectasia: the next generation of ATM functions

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Epigenetic silencing mediates mitochondria stress-induced longevity

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Pathological neoangiogenesis depends on oxidative stress regulation by ATM

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Roles of UVA radiation and DNA damage responses in melanoma pathogenesis

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The role of cellular senescence and SASP in tumour microenvironment

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Reactive Molecule Species and Antioxidative Mechanisms in Normal Skin and Skin Aging

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Accumulation of Cytoplasmic DNA Due to ATM Deficiency Activates the Microglial Viral Response System with Neurotoxic Consequences

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Oxidized ATM-mediated glycolysis enhancement in breast cancer-associated fibroblasts contributes to tumor invasion through lactate as metabolic coupling

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ATM is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging

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ATM protein kinase: the linchpin of cellular defenses to stress

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Metabolic effects of resveratrol: Addressing the controversies

Bitterman, J. L., & Chung, J. H. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1808-8 · Cited by 109 · see citing works

Stem Cells, Redox Signaling, and Stem Cell Aging

Liang, R., & Ghaffari, S. (2014) · Antioxidants &amp; Redox Signaling · doi:10.1089/ars.2013.5300 · Cited by 106 · see citing works

APE2 is required for ATR-Chk1 checkpoint activation in response to oxidative stress

Willis, J., Patel, Y., Lentz, B. L., & Yan, S. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1301445110 · Cited by 100 · see citing works

New insights into the roles of ATM and DNA-PKcs in the cellular response to oxidative stress

Chen, B. P. C., Li, M., & Asaithamby, A. (2012) · Cancer Letters · doi:10.1016/j.canlet.2011.12.004 · Cited by 84 · see citing works

Oxidative Stress, Bone Marrow Failure, and Genome Instability in Hematopoietic Stem Cells

Richardson, C., Yan, S., & Vestal, C. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16022366 · Cited by 81 · see citing works

ATM regulation of IL-8 links oxidative stress to cancer cell migration and invasion

Chen, W.-T., Ebelt, N. D., Stracker, T. H., Xhemalce, B., Van Den Berg, C. L., & Miller, K. M. (2015) · eLife · doi:10.7554/elife.07270 · Cited by 73 · see citing works

Loss of <i>caspase-2</i> augments lymphomagenesis and enhances genomic instability in <i>Atm</i> -deficient mice

Puccini, J., Shalini, S., Voss, A. K., Gatei, M., Wilson, C. H., Hiwase, D. K., Lavin, M. F., Dorstyn, L., & Kumar, S. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1311947110 · Cited by 69 · see citing works

ATM and MET kinases are synthetic lethal with nongenotoxic activation of p53

Sullivan, K. D., Padilla-Just, N., Henry, R. E., Porter, C. C., Kim, J., Tentler, J. J., Eckhardt, S. G., Tan, A. C., DeGregori, J., & Espinosa, J. M. (2012) · Nature Chemical Biology · doi:10.1038/nchembio.965 · Cited by 67 · see citing works

DNA repair mechanisms protect our genome from carcinogenesis

Moraes, M. C. S. (2012) · Frontiers in Bioscience · doi:10.2741/3992 · Cited by 64 · see citing works

DNA damage-associated oligodendrocyte degeneration precedes amyloid pathology and contributes to Alzheimer’s disease and dementia

Tse, K., Cheng, A., Ma, F., & Herrup, K. (2018) · Alzheimer's &amp; Dementia · doi:10.1016/j.jalz.2017.11.010 · Cited by 56 · see citing works

Severe mitochondrial damage associated with low-dose radiation sensitivity in ATM- and NBS1-deficient cells

Shimura, T., Kobayashi, J., Komatsu, K., & Kunugita, N. (2016) · Cell Cycle · doi:10.1080/15384101.2016.1156276 · Cited by 55 · see citing works

Ataxia–Telangiectasia Mutated Kinase in the Control of Oxidative Stress, Mitochondria, and Autophagy in Cancer: A Maestro With a Large Orchestra

Stagni, V., Cirotti, C., & Barilà, D. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00073 · Cited by 52 · see citing works

Nucleotide excision repair activity on DNA damage induced by photoactivated methylene blue

Berra, C. M., de Oliveira, C. S., Garcia, C. C. M., Rocha, C. R. R., Lerner, L. K., Lima, L. C. D. A., Baptista, M. D. S., & Menck, C. F. M. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.03.026 · Cited by 40 · see citing works

Histone H2AX deficiency causes neurobehavioral deficits and impaired redox homeostasis

Weyemi, U., Paul, B. D., Snowman, A. M., Jailwala, P., Nussenzweig, A., Bonner, W. M., & Snyder, S. H. (2018) · Nature Communications · doi:10.1038/s41467-018-03948-9 · Cited by 37 · see citing works

Cell cycle stage-specific roles of Rad18 in tolerance and repair of oxidative DNA damage

Yang, Y., Durando, M., Smith-Roe, S. L., Sproul, C., Greenwalt, A. M., Kaufmann, W., Oh, S., Hendrickson, E. A., & Vaziri, C. (2013) · Nucleic Acids Research · doi:10.1093/nar/gks1325 · Cited by 33 · see citing works

A nervous predisposition to unrepaired DNA double strand breaks

Reynolds, J. J., & Stewart, G. S. (2013) · DNA Repair · doi:10.1016/j.dnarep.2013.04.011 · Cited by 26 · see citing works

ATM modulates subventricular zone neural stem cell maintenance and senescence through Notch signaling pathway

Dong, C., Wang, X., Sun, L., Zhu, L., Yang, D., Gao, S., Zhang, W., Ling, B., Liang, A., Gao, Z., et al. (2022) · Stem Cell Research · doi:10.1016/j.scr.2021.102618 · Cited by 16 · see citing works

Lymphocytes in ataxia telangiectasia: Implications of the DNA repair defect

Lavin, M. F., & Kidson, C. (1978) · Clinical Immunology and Immunopathology · doi:10.1016/0090-1229(78)90188-5 · Cited by 16 · see citing works

The role of progesterone-induced blocking factor (PIBF) in invasion of primary ovarian tumour cells

Balassa, T., Berta, G., Bohonyi, N., et al. (2017) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2017.07.027

Cellular Responses to DNA Damage

Klapacz, J., & Gollapudi, B. B. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.95611-3 · Cited by 2 · see citing works

DNA damage repair and cardiovascular diseases

Shukla, P. C., Singh, K. K., Yanagawa, B., Teoh, H., & Verma, S. (2010) · Canadian Journal of Cardiology · doi:10.1016/s0828-282x(10)71055-2 · Cited by 45 · see citing works

Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress

Yan, S., Sorrell, M., & Berman, Z. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1666-4 · Cited by 247 · see citing works