Nemo‐like kinase is involved in NGF‐induced neurite outgrowth via phosphorylating MAP1B and paxillin

Ishitani, Tohru; Ishitani, Shizuka; Matsumoto, Kunihiro; Itoh, Motoyuki

doi:10.1111/j.1471-4159.2009.06400.x

Cited by 44Nerve injury and regenerationAxon Guidance and Neuronal SignalingProtein Kinase Regulation and GTPase Signaling

Nemo‐like kinase is involved in NGF‐induced neurite outgrowth via phosphorylating MAP1B and paxillin

Ishitani, Tohru, Ishitani, Shizuka, Matsumoto, Kunihiro, Itoh, Motoyuki·2009·Journal of Neurochemistry

DOI 10.1111/j.1471-4159.2009.06400.x

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Abstract

Nerve growth factor (NGF) promotes neurite outgrowth through regulating cytoskeletal organization and cell adhesion. These activities are modulated by protein phosphorylation. Nemo‐like kinase (NLK) is an evolutionarily conserved MAP kinase‐like kinase that phosphorylates several transcription factors. Although NLK is known to be expressed at relatively high levels in the nervous system, its function is not well understood. We found that NGF promotes the translocation of NLK to PC12 cells’ leading edges, and triggers NLK kinase activity in them. Activated NLK directly phosphorylates microtubule‐associated protein‐1B (MAP1B) and the focal adhesion adaptor protein, paxillin. Knockdown of NLK attenuates the phosphorylation of both paxillin and MAP1B and inhibits both the NGF‐induced re‐distribution of F‐actin and neurite outgrowth. We also discovered that NLK is a LiCl‐sensitive kinase. LiCl is known to block NGF‐induced neurite outgrowth and the phosphorylation of MAP1B and paxillin in PC12 cells. Therefore, the effects of LiCl are mediated in part by blocking NLK activity. These results suggest that NLK controls the dynamics of the cytoskeleton downstream of NGF signaling.

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Authors: Ishitani, T., Ishitani, S., Matsumoto, K., & Itoh, M.
Affiliations: Kyushu University (JP)
Nagoya University (JP)
Corresponding author: Ishitani, Tohru
Itoh, Motoyuki
ORCID: Ishitani, Tohru
Ishitani, Shizuka
Matsumoto, Kunihiro
Itoh, Motoyuki
Venue: Journal of Neurochemistry
Publisher: Wiley
Published: 2009-11-04
Volume: 111
Issue: 5
Pages: 1104-1118
ISSN: 0022-3042 (ISSN-L)
1471-4159
DOI: 10.1111/j.1471-4159.2009.06400.x
OpenAlex: W2105608270
Semantic Scholar: 57c57d060bb819a1a39d777c34d1ad88a5849f88
Cited by: 44
References: 59
Citations by year: 2025: 1 · 2024: 1 · 2023: 2 · 2021: 5 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 4 · 2016: 4 · 2015: 4 · 2014: 5 · 2013: 3 · 2012: 4
FWCI: 1.51
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Neurochemistry (publishedVersion)
PubMed (publishedVersion)
Funders: Ministry of Education, Culture, Sports, Science and Technology
Japan Society for the Promotion of Science (21247031)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Keywords: Nemo-like kinase, nerve growth factor, neurite outgrowth, paxillin phosphorylation, PC12 cells, cytoskeletal dynamics, F-actin redistribution, focal adhesions, lithium chloride, NGF signaling
MeSH terms: Glycogen Synthase Kinase 3 beta, Adenosine Triphosphate, Animals, Cell Line, Humans, Microtubule-Associated Proteins, Models, Biological, Neurons, Phosphorylation, Serine, Time Factors, Transfection, Signal Transduction, Guanosine 5'-O-(3-Thiotriphosphate), Neurites, Protein Serine-Threonine Kinases, Nerve Growth Factor, Protein Transport, RNA, Small Interfering, Glycogen Synthase Kinase 3, Immunoprecipitation, Intracellular Signaling Peptides and Proteins, Green Fluorescent Proteins, Rats, Paxillin

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Nemo‐like kinase is involved in NGF‐induced neurite outgrowth via phosphorylating MAP1B and paxillin

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