The DOI matches its Crossref record; 128 of the 128 references it cites were found in a registry or an index.
Hydrogen sulfide as a gasotransmitter
Open accessAbstract
J. Neurochem.(2010) 10.1111/j.1471‐4159.2010.06580.x Nitric oxide (NO) and carbon monoxide (CO) are well established as messenger molecules throughout the body, gasotransmitters, based on striking alterations in mice lacking the appropriate biosynthetic enzymes. Hydrogen sulfide (H 2 S) is even more chemically reactive, but until recently there was little definitive evidence for its physiologic formation. Cystathionine β‐synthase (EC 4.2.1.22), and cystathionine γ‐lyase (CSE; EC 4.4.1.1), also known as cystathionine, can generate H 2 S from cyst(e)ine. Very recent studies with mice lacking these enzymes have established that CSE is responsible for H 2 S formation in the periphery, while in the brain cystathionine β‐synthase is the biosynthetic enzyme. Endothelial‐derived relaxing factor activity is reduced 80% in the mesenteric artery of mice with deletion of CSE, establishing H 2 S as a major physiologic endothelial‐derived relaxing factor. H 2 S appears to signal predominantly by S‐sulfhydrating cysteines in its target proteins, analogous to S‐nitrosylation by NO. Whereas S‐nitrosylation typically inhibits enzymes,S‐sulfhydration activates them.S‐nitrosylation basally affects 1–2% of its target proteins, while 10–25% of H 2 S target proteins are S‐sulfhydrated. In summary, H 2 S appears to be a physiologic gasotransmitter of comparable importance to NO and carbon monoxide.
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Metadata
- Authors
- Gadalla, M. M., & Snyder, S. H.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 2010-03-03
- Volume
- 113
- Issue
- 1
- Pages
- 14-26
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W2014641242
- Cited by
- 498
- References
- 128
- FWCI
- 19.05
- Type
- journal article
- Language
- en
- Open access
- bronze
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