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UCP1 deficiency increases susceptibility to diet‐induced obesity with age
Open accessAbstract
Summary: Loss of nonshivering thermogenesis in mice by inactivation of the mitochondrial uncoupling protein gene (Ucp1−/– mice) causes increased sensitivity to cold and unexpected resistance to diet‐induced obesity at a young age. To clarify the role of UCP1 in body weight regulation throughout life and influence of UCP1 deficiency on longevity, we longitudinally analyzed the phenotypes of Ucp1−/– mice maintained in a room at 23 °C. There was no difference in body weight and lifespan between genotypes under the standard chow diet condition, whereas the mutant mice developed obesity with age under the high‐fat (HF) diet condition. Compared with Ucp1+/+ mice, Ucp1−/– mice showed increased expression of genes related to thermogenesis and fatty acid metabolism, such as β3‐adrenergic receptor, in adipose tissues of the 3‐month‐old mutants; however, the augmented expression was reduced in Ucp1+/+ mice in 11‐month‐old Ucp1−/– mice fed the HF diet. Likewise, the increased levels of UCP3 and cAMP‐dependent protein kinase in the brown adipose tissue of Ucp1−/– mice given the standard diet were decreased significantly in that of Ucp1−/– mice fed the HF diet, which animals showed impaired norepinephrine‐induced lipolysis in their adipose tissues. These results suggest profound attenuation of β‐adrenergic responsiveness and fatty acid utilization in Ucp1−/– mice fed the HF diet, bringing them to late‐onset obesity. Our findings provide evidence that UCP1 is neither essential for body weight regulation nor for longevity under conditions of standard diet and normal housing temperature, but deficiency increases susceptibility to obesity with age in combination with HF diet.
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“In fact, altered UCP1 expression (UCP1-deficient or transgenic mice) leads to dysregulated sensitivity to cold exposure and body weight control ([40](#B40), [42](#B42), [86](#B86), [87](#B87), [98](#B98)).”
From Mitochondrial fatty acid oxidation in obesity (2013) · cites this paper as [86]
In the citing paper
“UCP1-deficient mice are cold sensitive 31 and exhibit increased susceptibility to diet-induced obesity 32,33.”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [32]
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Metadata
- Authors
- Kontani, Y., Wang, Y., Kimura, K., Inokuma, K. ‐., Saito, M., Suzuki‐Miura, T., Wang, Z., Sato, Y., Mori, N., & Yamashita, H.
- Affiliations
- Kanazawa Medical University (JP)
- Hokkaido University (JP)
- Corresponding author
- Yamashita, H.
- Venue
- Aging Cell
- Publisher
- Wiley
- Published
- 2005-05-09
- Volume
- 4
- Issue
- 3
- Pages
- 147-155
- ISSN
- 1474-9718 (ISSN-L)
- 1474-9726
- OpenAlex
- W1755714470
- Cited by
- 207
- References
- 40
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 5 · 2023: 11 · 2022: 10 · 2021: 13 · 2020: 9 · 2019: 11 · 2018: 18 · 2017: 8 · 2016: 12 · 2015: 20 · 2014: 12 · 2013: 9 · 2012: 13
- FWCI
- 2.61
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Aging Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- UCP1, non-shivering thermogenesis, diet-induced obesity, high-fat diet, aging, body weight regulation, longevity, brown adipose tissue, beta3-adrenergic receptor, UCP3, protein kinase A, fatty acid metabolism, adipose tissue, beta-adrenergic responsiveness
- MeSH terms
- Uncoupling Protein 1, Animals, Body Weight, Adipose Tissue, Brown, Carrier Proteins, Data Interpretation, Statistical, Diet, Fatty Acids, Humans, Ion Channels, Longevity, Longitudinal Studies, Membrane Proteins, Mice, Inbred C57BL, Obesity, Blotting, Northern, Mice, Knockout, Thermogenesis, Mitochondrial Proteins, Mice
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