Cited by 2,328Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic DiseasesPeroxisome Proliferator-Activated Receptors

Brown and beige fat: Development, function and therapeutic potential

Harms, Matthew, Seale, Patrick·2013·Nature Medicine

Abstract

Adipose tissue, best known for its role in fat storage, can also suppress weight gain and metabolic disease through the action of specialized, heat-producing adipocytes. Brown adipocytes are located in dedicated depots and express constitutively high levels of thermogenic genes, whereas inducible 'brown-like' adipocytes, also known as beige cells, develop in white fat in response to various activators. The activities of brown and beige fat cells reduce metabolic disease, including obesity, in mice and correlate with leanness in humans. Many genes and pathways that regulate brown and beige adipocyte biology have now been identified, providing a variety of promising therapeutic targets for metabolic disease.

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Crossref · 10.1038/nm.3361

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194 of 194 references verified0 citation errors · 0 not checkable

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Authors
Harms, M., & Seale, P.
Affiliations
University of Pennsylvania (US)
Corresponding author
Seale, Patrick
Venue
Nature Medicine
Published
2013-09-29
Volume
19
Issue
10
Pages
1252-1263
ISSN
  • 1078-8956 (ISSN-L)
  • 1546-170X
OpenAlex
W2119649463
Cited by
2,328
References
194
Citations by year
2026: 110 · 2025: 115 · 2024: 169 · 2023: 156 · 2022: 195 · 2021: 191 · 2020: 208 · 2019: 236 · 2018: 234 · 2017: 238 · 2016: 200 · 2015: 170 · 2014: 104 · 2012: 1
FWCI
17.12
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institutes of Health (1dp2od007288-01)
Topics
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Keywords
brown adipocytes, beige adipocytes, thermogenesis, obesity, metabolic disorders, adipose tissue, white adipose tissue, thermogenic gene expression, obesity treatment, adipocyte development
MeSH terms
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Animals, Adipose Tissue, Brown, Humans, Metabolic Diseases, Sympathetic Nervous System, Transcription Factors, Adipocytes, Mice

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