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Cited by 264

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Low rates of hydrogen peroxide production by isolated heart mitochondria associate with long maximum lifespan in vertebrate homeotherms

Open access
Lambert, Adrian J., Boysen, Helen M., Buckingham, Julie A., Yang, Ting, Podlutsky, Andrej, Austad, Steven N., Kunz, Thomas H., Buffenstein, Rochelle, Brand, Martin D.·2007·Aging Cell
DOI 10.1111/j.1474-9726.2007.00312.x
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Abstract

Summary: An inverse correlation between free radical production by isolated mitochondria and longevity in homeotherms has been reported, but previous comparative studies ignored possible confounding effects of body mass and phylogeny. We investigated this correlation by comparing rates of hydrogen peroxide (H 2 O 2) production by heart mitochondria isolated from groups or pairs of species selected to have very different maximum lifespans but similar body masses (small mammals, medium‐sized mammals, birds). During succinate oxidation, H 2 O 2 production rates were generally lower in the longer‐lived species; the differences arose at complex I of the electron transport chain during reverse electron transport. Additional data were obtained from large species and the final dataset comprised mouse, rat, white‐footed mouse, naked mole‐rat, Damara mole‐rat, guinea pig, baboon, little brown bat, Brazilian free‐tailed bat, ox, pigeon and quail. In this dataset, maximum lifespan was negatively correlated with H 2 O 2 production at complex I during reverse electron transport. Analysis of residual maximum lifespan and residual H 2 O 2 production revealed that this correlation was even more significant after correction for effects of body mass. To remove effects of phylogeny, independent phylogenetic contrasts were obtained from the residuals. These revealed an inverse association between maximum lifespan and H 2 O 2 production that was significant by sign test, but fell short of significance by regression analysis. These findings indicate that enhanced longevity may be causally associated with low free radical production by mitochondria across species over two classes of vertebrate homeotherms.

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Crossref · 10.1111/j.1474-9726.2007.00312.x

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Metadata

Authors
Lambert, A. J., Boysen, H. M., Buckingham, J. A., Yang, T., Podlutsky, A., Austad, S. N., Kunz, T. H., Buffenstein, R., & Brand, M. D.
Venue
Aging Cell
Publisher
Wiley
Published
2007-06-03
Volume
6
Issue
5
Pages
607-618
ISSN
  • 1474-9718 (ISSN-L)
  • 1474-9726
DOI
10.1111/j.1474-9726.2007.00312.x
OpenAlex
W1995219619
Cited by
264
References
5
FWCI
5.91
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Low rates of hydrogen peroxide production by isolated heart mitochondria associate with long maximum lifespan in vertebrate homeotherms. https://app.cochat.ai/papers/10.1111/j.1474-9726.2007.00312.x
The paper
Lambert, A. J., Boysen, H. M., Buckingham, J. A., Yang, T., Podlutsky, A., Austad, S. N., Kunz, T. H., Buffenstein, R., & Brand, M. D. (2007). Low rates of hydrogen peroxide production by isolated heart mitochondria associate with long maximum lifespan in vertebrate homeotherms. Aging Cell. https://doi.org/10.1111/j.1474-9726.2007.00312.x

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.