Senescence and aging: the critical roles of p53

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p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling

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Telomere dysfunction induces metabolic and mitochondrial compromise

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p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis

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p63 Is Essential for the Proliferative Potential of Stem Cells in Stratified Epithelia

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Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer

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The wanderings of a free radical

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Delayed ageing through damage protection by the Arf/p53 pathway

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Mitochondrial Dysfunction Contributes to Oncogene-Induced Senescence

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A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis

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Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy

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Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer

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Paradoxical suppression of cellular senescence by p53

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TAp63α induces apoptosis by activating signaling via death receptors and mitochondria

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ΔNp63α is an oncogene that targets chromatin remodeler Lsh to drive skin stem cell proliferation and tumorigenesis

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E2F7, a novel target, is up-regulated by p53 and mediates DNA damage-dependent transcriptional repression

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Ink4a/Arf links senescence and aging

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The p16INK4A tumor suppressor regulates cellular oxidative stress

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Transcriptional regulation of cellular senescence

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Loss of HtrA2/Omi activity in non-neuronal tissues of adult mice causes premature aging

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Roles of HAUSP-mediated p53 regulation in central nervous system development

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ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age‐Related Diseases

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PDL1 Regulation by p53 via miR-34

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Role of p53 in the Regulation of Cellular Senescence

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The Aging Epigenome

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p16(Ink4a) and senescence-associated β-galactosidase can be induced in macrophages as part of a reversible response to physiological stimuli

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p53, cancer and the immune response

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Inflammation and DNA damage: cause, effect or both

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Metformin regulates mitochondrial biogenesis and senescence through AMPK mediated H3K79 methylation: relevance in age-associated vascular dysfunction

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Cell-cycle arrest and senescence in TP53-wild type renal carcinoma by enhancer RNA-P53-bound enhancer regions 2 (p53BER2) in a p53-dependent pathway

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Circadian gene variants in cancer

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Aging microglia

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Ionizing radiation induces long-term senescence in endothelial cells through mitochondrial respiratory complex II dysfunction and superoxide generation

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DNA repair and aging: The impact of the p53 family

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DNA damage in the oligodendrocyte lineage and its role in brain aging

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The p53/p21/p16 and <scp>PI3K</scp>/Akt signaling pathways are involved in the ameliorative effects of maltol on D‐galactose‐induced liver and kidney aging and injury

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P53 and The Immune Response: 40 Years of Exploration—A Plan for the Future

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Interaction between autophagy and senescence is required for dihydroartemisinin to alleviate liver fibrosis

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Emergence of Microglia Bearing Senescence Markers During Paralysis Progression in a Rat Model of Inherited ALS

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DNA repair deficiency and senescence in concussed professional athletes involved in contact sports

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Activation of p53 in Down Syndrome and in the Ts65Dn mouse brain is associated with a pro-apoptotic phenotype

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Differential expression of senescence tumour markers and its implications on survival outcomes of breast cancer patients

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Ginkgo Biloba Extract Can Antagonize Subchronic Arsenite Exposure-Induced Hepatocyte Senescence by Inhibiting Oxidative Damage and Inflammation in Rats

Chen, X., Wu, F., Chen, C., Ren, Q., & Zhang, A. (2024) · Biological Trace Element Research · doi:10.1007/s12011-023-04021-3 · Cited by 11 · see citing works