The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Visceral adipose tissue modulates mammalian longevity
Open accessAbstract
Summary: Caloric restriction (CR) can delay many age‐related diseases and extend lifespan, while an increase in adiposity is associated with enhanced disease risk and accelerated aging. Among the various fat depots, the accrual of visceral fat (VF) is a common feature of aging, and has been shown to be the most detrimental on metabolic syndrome of aging in humans. We have previously demonstrated that surgical removal of VF in rats improves insulin action; thus, we set out to determine if VF removal affects longevity. We prospectively studied lifespan in three groups of rats: ad libitum‐fed (AL‐fed), CR (Fed 60% of AL) and a group of AL‐fed rats with selective removal of VF at 5 months of age (VF‐removed rats). We demonstrate that compared to AL‐fed rats, VF‐removed rats had a significant increase in mean (p < 0.001) and maximum lifespan (p < 0.04) and significant reduction in the incidence of severe renal disease (p < 0.01). CR rats demonstrated the greatest mean and maximum lifespan (p < 0.001) and the lowest rate of death as compared to AL‐fed rats (0.13). Taken together, these observations provide the most direct evidence to date that a reduction in fat mass, specifically VF, may be one of the possible underlying mechanisms of the anti‐aging effect of CR.
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Carr, D. B., Utzschneider, K. M., Hull, R. L., Kodama, K., Retzlaff, B. M., Brunzell, J. D., Shofer, J. B., Fish, B. E., Knopp, R. H., & Kahn, S. E. (2004) · Diabetes · doi:10.2337/diabetes.53.8.2087 · Cited by 993
Absence of an Effect of Liposuction on Insulin Action and Risk Factors for Coronary Heart Disease
Klein, S., Fontana, L., Young, V. L., Coggan, A. R., Kilo, C., Patterson, B. W., & Mohammed, B. S. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa033179 · Cited by 917
Cited by
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The Critical Role of Metabolic Pathways in Aging
Barzilai, N., Huffman, D. M., Muzumdar, R. H., & Bartke, A. (2012) · Diabetes · doi:10.2337/db11-1300 · Cited by 803
Self-citationInsulin Resistance and Atherosclerosis: Implications for Insulin-Sensitizing Agents
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Relationships between Rodent White Adipose Fat Pads and Human White Adipose Fat Depots
Chusyd, D. E., Wang, D., Huffman, D. M., & Nagy, T. R. (2016) · Frontiers in Nutrition · doi:10.3389/fnut.2016.00010 · Cited by 357
Self-citationAnimal models of aging research: implications for human aging and age-related diseases
Mitchell, S. J., Scheibye-Knudsen, M., Longo, D. L., & de Cabo, R. (2015) · Annual Review of Animal Biosciences · doi:10.1146/annurev-animal-022114-110829 · Cited by 328
Metadata
- Authors
- Muzumdar, R., Allison, D. B., Huffman, D. M., Ma, X., Atzmon, G., Einstein, F. H., Fishman, S., Poduval, A. D., McVei, T., Keith, S. W., & Barzilai, N.
- Venue
- Aging Cell
- Publisher
- Wiley
- Published
- 2008-03-18
- Volume
- 7
- Issue
- 3
- Pages
- 438-440
- ISSN
- 1474-9718 (ISSN-L)
- 1474-9726
- OpenAlex
- W1973246057
- Cited by
- 213
- References
- 2
- FWCI
- 3.87
- Type
- journal article
- Language
- en
- Open access
- green
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- Muzumdar, R., Allison, D. B., Huffman, D. M., Ma, X., Atzmon, G., Einstein, F. H., Fishman, S., Poduval, A. D., McVei, T., Keith, S. W., & Barzilai, N. (2008). Visceral adipose tissue modulates mammalian longevity. Aging Cell. https://doi.org/10.1111/j.1474-9726.2008.00391.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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