The DOI matches its Crossref record; 151 of the 151 references it cites were found in a registry or an index.
Relationships between Rodent White Adipose Fat Pads and Human White Adipose Fat Depots
Open accessAbstract
The objective of this review was to compare and contrast the physiological and metabolic profiles of rodent white adipose fat pads with white adipose fat depots in humans. Human fat distribution and its metabolic consequences have received extensive attention, but much of what has been tested in translational research has relied heavily on rodents. Unfortunately, the validity of using rodent fat pads as a model of human adiposity has received less attention. There is a surprisingly lack of studies demonstrating an analogous relationship between rodent and human adiposity on obesity-related comorbidities. Therefore, we aimed to compare known similarities and disparities in terms of white adipose tissue (WAT) development and distribution, sexual dimorphism, weight loss, adipokine secretion, and aging. While the literature supports the notion that many similarities exist between rodents and humans, notable differences emerge related to fat deposition and function of WAT. Thus, further research is warranted to more carefully define the strengths and limitations of rodent WAT as a model for humans, with a particular emphasis on comparable fat depots, such as mesenteric fat.
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Cites
The metabolic phenotype in obesity: Fat mass, body fat distribution, and adipose tissue function
Goossens, G. H. (2017) · Obesity Facts · doi:10.1159/000471488 · Cited by 8,481
Mechanisms of fatty acid-induced inhibition of glucose uptake.
Boden, G., Chen, X., Ruiz, J., White, J. V., & Rossetti, L. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117252 · Cited by 3,705
Subcutaneous Adipose Tissue Releases Interleukin-6, But Not Tumor Necrosis Factor-α,in Vivo1
Mohamed-Ali, V., Goodrick, S., Rawesh, A., Katz, D. R., Miles, J. M., Yudkin, J. S., Klein, S., & Coppack, S. W. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.12.4450 · Cited by 2,012
Epstein, F. H., Levin, E. R., Gardner, D. G., & Samson, W. K. (1998) · New England Journal of Medicine · doi:10.1056/nejm199807303390507 · Cited by 1,927
A transgenic model of visceral obesity and the metabolic syndrome
Masuzaki, H., Paterson, J., Shinyama, H., Morton, N. M., Mullins, J. J., Seckl, J. R., & Flier, J. S. (2001) · Science · doi:10.1126/science.1066285 · Cited by 1,766
Developmental Origin of Fat: Tracking Obesity to Its Source
Gesta, S., Tseng, Y.-H., & Kahn, C. R. (2007) · Cell · doi:10.1016/j.cell.2007.10.004 · Cited by 1,508
Visceral fat adipokine secretion is associated with systemic inflammation in obese humans
Fontana, L., Eagon, J. C., Trujillo, M. E., Scherer, P. E., & Klein, S. (2007) · Diabetes · doi:10.2337/db06-1656 · Cited by 1,417 · cited 5×
“As mentioned previously, leptin is preferentially secreted in humans from peripheral subcutaneous depots at a higher rate than from VAT (103, 104), indicating that subcutaneous fat is a chief source of leptin production.”
BackgroundInfluentialBody mass index and percent body fat: a meta analysis among different ethnic groups
Deurenberg, P., Yap, M., & van Staveren, W. (1998) · International Journal of Obesity · doi:10.1038/sj.ijo.0800741 · Cited by 1,390
Obesity-associated improvements in metabolic profile through expansion of adipose tissue
Kim, J.-Y., van de Wall, E., Laplante, M., Azzara, A., Trujillo, M. E., Hofmann, S. M., Schraw, T., Durand, J. L., Li, H., Li, G., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31021 · Cited by 1,310 · cited 2×
“Similar to the collagen VI model, overexpression of adiponectin in ob/ob mice lead to an increase in adipocyte cell number and, thus, increased adipose tissue mass, specifically SAT (134).”
BackgroundMethodThe Body-Mass Index of Twins Who Have Been Reared Apart
Stunkard, A. J., Harris, J. R., Pedersen, N. L., & McClearn, G. E. (1990) · New England Journal of Medicine · doi:10.1056/nejm199005243222102 · Cited by 1,286
Cited by
Chait, A., & den Hartigh, L. J. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.00022 · Cited by 1,529
Peng, S., Xiao, W., Ju, D., Sun, B., Hou, N., Liu, Q., Wang, Y., Zhao, H., Gao, C., Zhang, S., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aau7116 · Cited by 312
Obesity May Accelerate the Aging Process
Salvestrini, V., Sell, C., & Lorenzini, A. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00266 · Cited by 260
Estradiol signaling mediates gender difference in visceral adiposity via autophagy
Tao, Z., Zheng, L. D., Smith, C., Luo, J., Robinson, A., Almeida, F. A., Wang, Z., Olumi, A. F., Liu, D., & Cheng, Z. (2018) · Cell Death & Disease · doi:10.1038/s41419-018-0372-9 · Cited by 63
Characterization of regulatory T cells in obese omental adipose tissue in humans
Wu, D., Han, J. M., Yu, X., Lam, A. J., Hoeppli, R. E., Pesenacker, A. M., Huang, Q., Chen, V., Speake, C., Yorke, E., et al. (2019) · European Journal of Immunology · doi:10.1002/eji.201847570 · Cited by 55
Metadata
- Authors
- Chusyd, D. E., Wang, D., Huffman, D. M., & Nagy, T. R.
- Venue
- Frontiers in Nutrition
- Publisher
- Frontiers Media SA
- Published
- 2016-04-19
- Volume
- 3
- Pages
- 10-10
- ISSN
- 2296-861X (ISSN-L)
- OpenAlex
- W2336311611
- Cited by
- 357
- References
- 151
- FWCI
- 20.53
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
