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Repression of the SUMO‐specific protease Senp1 induces p53‐dependent premature senescence in normal human fibroblasts
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Summary: The proliferative lifespan of normal somatic human cells in culture terminates in a permanent growth‐arrested state known as replicative senescence. In this study, we show that RNA interference‐mediated repression of the genes encoding the small ubiquitin‐related modifier (SUMO)‐specific proteases, Senp1, Senp2, and Senp7, induced low passage primary human fibroblasts to senesce rapidly. Following Senp1 repression, we observed a global increase in sumoylated proteins and in the number and size of nuclear SUMO‐containing promyelocytic leukemia (PML) bodies. SUMO/PML bodies also increased during replicative senescence. p53 transcriptional activity was enhanced towards known p53 target genes following repression of Senp1, and inhibition of p53 function prevented senescence after Senp1 repression. These data indicate that Senp1 repression induces p53‐mediated premature senescence and that SUMO proteases may thus be required for proliferation of normal human cells.
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pksC E. coli infection caused accumulation of SUMO1-conjugated p53 and was associated with a decrease in SENP1 expression.
“Accordingly, we observed an accumulation of SUMO1-conjugated p53, which is known to drive cellular senescence.17 This accumulation was associated with a decrease in SENP1 expression, a key enzyme involved in the control of the SUMOylation process.17”
From The bacterial genotoxin colibactin promotes colon tumor growth by modifying the tumor microenvironment (2014) · cites this paper as [17]
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Metadata
- Authors
- Yates, K. E., Korbel, G. A., Shtutman, M., Roninson, I. B., & DiMaio, D.
- Affiliations
- Yale University (US)
- Albany Research Institute (US)
- Corresponding author
- DiMaio, Daniel
- Venue
- Aging Cell
- Publisher
- Wiley
- Published
- 2008-09-17
- Volume
- 7
- Issue
- 5
- Pages
- 609-621
- ISSN
- 1474-9718 (ISSN-L)
- 1474-9726
- PMC
- PMC2745089
- OpenAlex
- W2051158533
- Cited by
- 77
- References
- 74
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 12 · 2023: 3 · 2022: 2 · 2021: 3 · 2020: 6 · 2019: 2 · 2018: 4 · 2017: 5 · 2016: 1 · 2015: 3 · 2014: 6 · 2013: 3 · 2012: 5
- FWCI
- 3.84
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Aging Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Scholar Commons (University of South Carolina) (submittedVersion)
- Funders
- Yale University
- National Institutes of Health (5p30ar041942-15)
- National Institute on Aging (R01AG017921, R01AG028687, AG17921)
- National Cancer Institute (R33CA095996, CA-16038, CA62099, CA95996, P01CA016038, R01CA062099)
- National Institute of Allergy and Infectious Diseases (AI55403, T32AI055403)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (P30-AR-041942, P30-AR41942)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- SENP1, SUMO protease, replicative senescence, premature senescence, p53, SUMOylation, PML bodies, human fibroblasts, cell proliferation, RNA interference
- MeSH terms
- Aged, Aging, Cells, Cultured, Cysteine Endopeptidases, Enzyme Repression, Fibroblasts, Humans, Endopeptidases, Down-Regulation, Tumor Suppressor Protein p53, SUMO-1 Protein, RNA Interference, Cell Proliferation
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