The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Tendon‐derived stem/progenitor cell aging: defective self‐renewal and altered fate
Open accessAbstract
Summary: Aging is a major risk factor for tendon injury and impaired tendon healing, but the basis for these relationships remains poorly understood. Here we show that rat tendon‐derived stem/progenitor cells (TSPCs) differ in both self‐renewal and differentiation capability with age. The frequency of TSPCs in tendon tissues of aged animals is markedly reduced based on colony formation assays. Proliferation rate is decreased, cell cycle progression is delayed and cell fate patterns are also altered in aged TSPCs. In particular, expression of tendon lineage marker genes is reduced while adipocytic differentiation increased. Cited2, a multi‐stimuli responsive transactivator involved in cell growth and senescence, is also downregulated in aged TSPCs while CD44, a matrix assembling and organizing protein implicated in tendon healing, is upregulated, suggesting that these genes participate in the control of TSPC function.
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Citations
Cites
Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment
Naveiras, O., Nardi, V., Wenzel, P. L., Hauschka, P. V., Fahey, F., & Daley, G. Q. (2009) · Nature · doi:10.1038/nature08099 · Cited by 1,129 · cited 2×
“similar to that observed in bone marrow, where adiposity was found to correlate inversely with the functionality of hematopoietic stem ⁄ progenitor cells (Naveiras et al., 2009).”
BackgroundResultDeficiencies in DNA damage repair limit the function of haematopoietic stem cells with age
Rossi, D. J., Bryder, D., Seita, J., Nussenzweig, A., Hoeijmakers, J., & Weissman, I. L. (2007) · Nature · doi:10.1038/nature05862 · Cited by 1,115
Mechanisms of hair graying: incomplete melanocyte stem cell maintenance in the niche
Nishimura, E. K., Granter, S. R., & Fisher, D. E. (2005) · Science · doi:10.1126/science.1099593 · Cited by 750
Cited by
Tendon and ligament regeneration and repair: Clinical relevance and developmental paradigm
Yang, G., Rothrauff, B. B., & Tuan, R. S. (2013) · Birth Defects Research Part C: Embryo Today: Reviews · doi:10.1002/bdrc.21041 · Cited by 469
Isolation and Characterization of Multipotent Rat Tendon-Derived Stem Cells
Rui, Y.-F., Lui, P. P. Y., Li, G., Fu, S. C., Lee, Y. W., & Chan, K. M. (2010) · Tissue Engineering Part A · doi:10.1089/ten.tea.2009.0529 · Cited by 342
ATF3 drives senescence by reconstructing accessible chromatin profiles
Zhang, C., Zhang, X., Huang, L., Guan, Y., Huang, X., Tian, X., Zhang, L., & Tao, W. (2021) · Aging Cell · doi:10.1111/acel.13315 · Cited by 84
“…Porciuncula, Yu, Iwakura, & David, 2019; Leveque et al., 2019; Q. Li et al., 2013; Limbad et al., 2020; Lowe & Raj, 2014; Nagano et al., 2016; Pan et al., 2019; Pantazi et al., 2019; Suwan et al., 2009; Wu, Pepowski, Takahashi, & Kron, 2019; Zhou et al., 2010), as are consistent with our results.”
Result
Metadata
- Authors
- Zhou, Z., Akinbiyi, T., Xu, L., Ramcharan, M., Leong, D. J., Ros, S. J., Colvin, A. C., Schaffler, M. B., Majeska, R. J., Flatow, E. L., & Sun, H. B.
- Venue
- Aging Cell
- Publisher
- Wiley
- Published
- 2010-09-16
- Volume
- 9
- Issue
- 5
- Pages
- 911-915
- ISSN
- 1474-9718 (ISSN-L)
- 1474-9726
- OpenAlex
- W1517715606
- Cited by
- 198
- References
- 3
- FWCI
- 7.77
- Type
- journal article
- Language
- en
- Open access
- green
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- Zhou, Z., Akinbiyi, T., Xu, L., Ramcharan, M., Leong, D. J., Ros, S. J., Colvin, A. C., Schaffler, M. B., Majeska, R. J., Flatow, E. L., & Sun, H. B. (2010). Tendon‐derived stem/progenitor cell aging: defective self‐renewal and altered fate. Aging Cell. https://doi.org/10.1111/j.1474-9726.2010.00598.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
