The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Plasma neuropeptide Y-like immunoreactivity and catecholamines during various degrees of sympathetic activation in man
Abstract
Neuropeptide Y-like immunoreactivity (NPY-LI) and catecholamine concentrations in plasma were analysed during and after 60 min of physical exercise at a work load corresponding to 70% of individual maximal oxygen uptake in nine healthy men of average physical fitness. Systemic plasma NPY-LI increased progressively from 18 +/- 3 to 81 +/- 19 pmol X 1(-1) in parallel with a 10-fold increase in noradrenaline (NA) concentration. The increase in plasma NPY-LI during exercise and the decrease after completion of exercise were much slower than the corresponding changes in NA concentration. This difference is probably related to a slower diffusion of NPY into systemic circulation after release, as well as to a longer half-life of NPY than of NA in plasma. Reversed phase HPLC and sephadex G-50 gel-filtration chromatography revealed that the main component of NPY-LI in plasma during exercise eluted in a similar position as synthetic human NPY. During exercise plasma NPY-LI correlated well with the plasma concentration of NA (r = 0.80), but not with that of adrenaline (ADR), suggesting a neuronal origin of NPY. The self-ratings of perceived exertion (RPE) were well correlated with the plasma concentrations of both NPY-LI and NA. No clear-cut veno-arterial concentration difference was observed for NPY-LI. Isometric handgrip and orthostatic test doubled plasma NA concentrations but did not cause any increase in plasma NPY-LI. No change in plasma tachykinin-like immunoreactivity was detected during exercise. The present data suggest that NPY is released together with NA during strong, but probably not during mild, sympathetic activation under physiological conditions in man.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“NPY is an excellent indicator of sympathetic activity, 34 which is more stable and has a significantly longer half life in plasma.35”
Citations
Cites
Perceived exertion as an indicator of somatic stress
Borg, G. (1970) · Journal of Rehabilitation Medicine · doi:10.2340/1650197719702239298 · Cited by 4,723
A Flexible System of Enzymatic Analysis
Lowry, O. H., & Passonneau, J. V. (1972) · Elsevier eBooks · doi:10.1016/b978-0-12-457950-7.x5001-3 · Cited by 4,050
Åstrand, P. O., & Ryhming, I. (1954) · Journal of Applied Physiology · doi:10.1152/jappl.1954.7.2.218 · Cited by 1,558
Neuropeptide Y: complete amino acid sequence of the brain peptide.
Tatemoto, K. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.18.5485 · Cited by 1,378
Lundberg, J. M., Terenius, L. Y., Hökfelt, T. G. M., Martling, C., Tatemoto, K., Mutt, V., Polak, J. M., Bloom, S. R., & Goldstein, M. (1982) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1982.tb07171.x · Cited by 1,199
Self-citationNeuropeptide Y co-exists and co-operates with noradrenaline in perivascular nerve fibers
Ekblad, E., Edvinsson, L. I., Wahlestedt, C., Uddman, R., Håkanson, R., & Sundler, F. (1984) · Regulatory Peptides · doi:10.1016/0167-0115(84)90064-8 · Cited by 741
High levels of neuropeptide Y in peripheral noradrenergic neurons in various mammals including man
Lundberg, J. M., Terenius, L. Y., Hökfelt, T. G. M., & Goldstein, M. (1983) · Neuroscience Letters · doi:10.1016/0304-3940(83)90401-9 · Cited by 616
Self-citationHjemdahl, P., Daleskog, M., & Kahan, T. (1979) · Life Sciences · doi:10.1016/0024-3205(79)90384-9 · Cited by 564
Self-citationCoexistence of peptides and classical neurotransmitters
Lundberg, J. M., & Hökfelt, T. G. M. (1983) · Trends in Neurosciences · doi:10.1016/0166-2236(83)90149-2 · Cited by 560
Self-citationLundberg, J. M., & Tatemoto, K. (1982) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1982.tb07157.x · Cited by 534
Self-citation
Research works printed but not linked: 3
- Hohorst H. J., 1962, Metoden der Enzymatischen Analyse, 266
- LundbergJ. M. PernowJ. FriedG.&ÄnggårdA.(1986c)Neuropeptide Y in relation to reserpine and adrenoceptor antagonst‐resistant sympathetic vascular effects in the cat spleen.Nauny‐Schmiedeberg's Arch Pharmacol in press.
- Simpson G. G., 1960, Quantitative Zoology, 232
Cited by
Sorted by citations
Neuropeptide Y and neuropeptide Y receptor subtypes in brain and peripheral tissues
Dumont, Y., Martel, J.-C., Fournier, A., St-Pierre, S. A., & Quirion, R. (1992) · Progress in Neurobiology · doi:10.1016/0301-0082(92)90038-g · Cited by 380
Impaired sympathetic vascular regulation in humans after acute dynamic exercise.
Halliwill, J. R., Taylor, J. A., & Eckberg, D. L. (1996) · The Journal of Physiology · doi:10.1113/jphysiol.1996.sp021592 · Cited by 381
Plasma neuropeptide-Y concentrations in humans exposed to military survival training
Morgan, C. A., Wang, S., Southwick, S. M., Rasmusson, A., Hazlett, G., Hauger, R. L., & Charney, D. S. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00239-5 · Cited by 298
Neuropeptide Y: the universal soldier
Pedrazzini, T., Pralong, F. P., & Grouzmann, E. (2003) · Cellular and Molecular Life Sciences · doi:10.1007/s000180300029 · Cited by 289
Kaye, D. M., Lambert, G. W., Lefkovits, J., Morris, M. J., Jennings, G., & Esler, M. (1994) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(94)90738-2 · Cited by 285
Metadata
- Authors
- Pernow, J., Lundberg, J. M., Kaijser, L., Hjemdahl, P., Theodorsson‐Norheim, E., Martinsson, A., & Pernow, B.
- Affiliations
- Karolinska University Hospital (SE)
- Corresponding author
- Pernow, John
- Venue
- Clinical Physiology
- Publisher
- Wiley
- Published
- 1986-12
- Volume
- 6
- Issue
- 6
- Pages
- 561-578
- ISSN
- 0144-5979 (ISSN-L)
- 1365-2281
- OpenAlex
- W2029651085
- Cited by
- 211
- References
- 36
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 2 · 2022: 3 · 2021: 3 · 2020: 1 · 2019: 1 · 2018: 4 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 1 · 2012: 2
- FWCI
- 3.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Keywords
- neuropeptide Y, catecholamines, norepinephrine, epinephrine, sympathetic activation, physical activity, perceived exertion, tachykinins, isometric handgrip, orthostatic test
- MeSH terms
- Adult, Blood Pressure, Epinephrine, Physical Exertion, Heart Rate, Humans, Male, Neuropeptide Y, Neuropeptides, Norepinephrine, Radioimmunoassay, Sympathetic Nervous System, Time Factors, Tachykinins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
