Cited by 159Neuropeptides and Animal PhysiologyCardiovascular, Neuropeptides, and Oxidative Stress ResearchHeart Rate Variability and Autonomic Control

Increases in plasma neuropeptide Y concentrations during sympathetic activation in man

Morris, M.J., Russell, A.E., Kapoor, V., Cain, M.D., Elliott, J.M., West, M.J., Wing, L.M.H., Chalmers, J.P.·1986·Journal of the Autonomic Nervous System

Abstract

Neuropeptide Y (NPY) coexists with noradrenaline in postganglionic sympathetic neurons. In order to test the hypothesis that NPY may be released along with catecholamines by activation of the sympathoadrenal system we measured plasma NPY-like immunoreactivity (NPY-LI) concentrations during cold pressor test, head up tilt and bicycle exercise in healthy volunteers. All 3 manoeuvres resulted in elevation of blood pressure, heart rate and plasma noradrenaline and adrenaline concentrations. These were accompanied by increases in plasma NPY-LI concentrations on cold pressor test and exercise, but not with head up tilt. The increases in both NPY-LI and catecholamines were greatest with exercise. These findings suggest that NPY is released at the same time as noradrenaline when sympathetic noradrenergic nerves are activated.

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Crossref · 10.1016/0165-1838(86)90089-5

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Authors
Morris, M. J., Russell, A. E., Kapoor, V., Cain, M. D., Elliott, J. M., West, M. J., Wing, L. M. H., & Chalmers, J. P.
Affiliations
Flinders Medical Centre (AU)
Venue
Journal of the Autonomic Nervous System
Publisher
Elsevier BV
Published
1986-10
Volume
17
Issue
2
Pages
143-149
ISSN
0165-1838 (ISSN-L)
OpenAlex
W2001937802
Cited by
159
References
22
Citations by year
2025: 2 · 2024: 3 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 3 · 2017: 1 · 2014: 4 · 2013: 2 · 2012: 3
FWCI
2.24
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of the Autonomic Nervous System (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Health Sciences › Medicine › Surgery › Cardiovascular, Neuropeptides, and Oxidative Stress Research
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Keywords
neuropeptide Y, sympathetic activation, sympathoadrenal system, norepinephrine, catecholamines, epinephrine, cold pressor test, head-up tilt, physical activity, blood pressure, heart rate
MeSH terms
Adult, Blood Pressure, Chromatography, High Pressure Liquid, Cold Temperature, Epinephrine, Exercise Test, Female, Heart Rate, Humans, Immersion, Male, Middle Aged, Neuropeptide Y, Norepinephrine, Posture, Radioimmunoassay, Sympathetic Nervous System

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