Increases in plasma neuropeptide Y concentrations during sympathetic activation in man
Abstract
Neuropeptide Y (NPY) coexists with noradrenaline in postganglionic sympathetic neurons. In order to test the hypothesis that NPY may be released along with catecholamines by activation of the sympathoadrenal system we measured plasma NPY-like immunoreactivity (NPY-LI) concentrations during cold pressor test, head up tilt and bicycle exercise in healthy volunteers. All 3 manoeuvres resulted in elevation of blood pressure, heart rate and plasma noradrenaline and adrenaline concentrations. These were accompanied by increases in plasma NPY-LI concentrations on cold pressor test and exercise, but not with head up tilt. The increases in both NPY-LI and catecholamines were greatest with exercise. These findings suggest that NPY is released at the same time as noradrenaline when sympathetic noradrenergic nerves are activated.
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NPY is an excellent indicator of sympathetic activity, being more stable and having a significantly longer half-life in plasma than norepinephrine.
“NPY is an excellent indicator of sympathetic activity, 34 which is more stable and has a significantly longer half life in plasma.35”
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NEUROPEPTIDE Y RADIO‐IMMUNOASSAY: CHARACTERIZATION AND APPLICATION
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Neuroendocrine immune pathways in chronic arthritis
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Neuropeptide Y in the Sympathetic Control of Blood Pressure in Hypertensive Subjects
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Post‐exercise depression of baroreflex slowing of the heart in humans
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Assessment of sympathoneural activity in clinical research
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Psychopharmacological possibilities in the acute disaster setting
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Release of neuropeptide Y and hemodynamic changes during surgical removal of human pheochromocytomas
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The sympathetic nervous system in healthy and hypertensive pregnancies: physiology or pathology?
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Sympathetic Neural Control in Humans with Anxiety‐Related Disorders
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NEUROPEPTIDE Y IN CORTISOL‐INDUCED HYPERTENSION IN MALE VOLUNTEERS
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Changes in cardiac neuropeptide Y after experimental myocardial infarction in rat
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- Authors
- Morris, M. J., Russell, A. E., Kapoor, V., Cain, M. D., Elliott, J. M., West, M. J., Wing, L. M. H., & Chalmers, J. P.
- Affiliations
- Flinders Medical Centre (AU)
- Venue
- Journal of the Autonomic Nervous System
- Publisher
- Elsevier BV
- Published
- 1986-10
- Volume
- 17
- Issue
- 2
- Pages
- 143-149
- ISSN
- 0165-1838 (ISSN-L)
- OpenAlex
- W2001937802
- Cited by
- 159
- References
- 22
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 3 · 2017: 1 · 2014: 4 · 2013: 2 · 2012: 3
- FWCI
- 2.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the Autonomic Nervous System (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Surgery › Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Keywords
- neuropeptide Y, sympathetic activation, sympathoadrenal system, norepinephrine, catecholamines, epinephrine, cold pressor test, head-up tilt, physical activity, blood pressure, heart rate
- MeSH terms
- Adult, Blood Pressure, Chromatography, High Pressure Liquid, Cold Temperature, Epinephrine, Exercise Test, Female, Heart Rate, Humans, Immersion, Male, Middle Aged, Neuropeptide Y, Norepinephrine, Posture, Radioimmunoassay, Sympathetic Nervous System
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