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Cited by 105Neuropeptides and Animal PhysiologyNeurotransmitter Receptor Influence on BehaviorRegulation of Appetite and Obesity

The hyperglycaemic effect of morphine

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FELDBERG, W., SHALIGRAM, S. V.·1972·British Journal of Pharmacology
DOI 10.1111/j.1476-5381.1972.tb06887.xPMC PMC1666375
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Abstract

Summary: . In the unanaesthetized cat, an injection of 0·75 mg of morphine into a lateral cerebral ventricle produced strong hyperglycaemia; on intravenous injection, 10 to 30 times larger doses were required. Other effects produced with both injections were shivering, pupillary dilatation, opening of the eyes, miaowing, periods of excitation, and analgesia. Between the periods of excitation the cat did not react to objects moving in front of its eyes and it had a vacant stare. . Noradrenaline, adrenaline, and 5‐hydroxytryptamine (5‐HT) injected intraventricularly (250 μg, twice) depressed the hyperglycaemia due to intraventricular morphine, and noradrenaline also depressed the hyperglycaemia due to intravenous morphine. Adrenaline produced the strongest and 5‐HT the weakest depression. 5‐HT did not depress the other effects of morphine, but the catecholamines depressed most of them; only analgesia and the vacant stare appeared to be unaffected. . Reserpine injected intraventricularly (0·5 mg, twice) greatly accentuated the hyperglycaemia as well as the other effects produced by intraventricular morphine, but pupillary dilatation and opening of the eyes no longer occurred; the protrusion of the nictitating membranes produced by the reserpine persisted. . Pentobarbitone sodium injected intraperitoneally in an anaesthetizing dose practically abolished the morphine hyperglycaemia, but injected intraventricularly in a dose of a few milligrammes, it had a two fold effect: depression followed by enhancement of the morphine hyperglycaemia. The enhancement may be due to sensitization of the effect of the adrenaline released by morphine, since adrenaline hyperglycaemia was enhanced as well. . Morphine did not seem to act on structures in the walls of either the lateral or third ventricle when producing its hyperglycaemic effect on intraventricular injection. The action may therefore be on more caudally situated parts of the neuro‐axis, on the central grey, on structures in the floor of the fourth ventricle or of the lateral recesses, or even on structures near the ventral surface of the brain stem.

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  • Paracetamol is regarded as a centrally acting temperature-lowering drug.

    “Paracetamol is regarded generally speaking as a centrally acting temperature lowering drug [18,22,131]”

    From Paracetamol (acetaminophen): A familiar drug with an unexplained mechanism of action (2021) · cites this paper as [18]

    The Introduction describes central sites of action for morphine-induced hyperglycaemia, and the Discussion addresses temperature regulation and shivering in cats. Searches for paracetamol and acetaminophen found no passage in our copy addressing whether paracetamol is a centrally acting temperature-lowering drug. (LLM, conf=0.76)

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  • The evidence supporting centrally mediated paracetamol-induced hypothermia, antipyresis and analgesia comes from a large volume of published literature spanning 6 decades, including direct in vivo experiments correlating pharmacological actions with reduction in CNS PGE2 synthesis.

    “The evidence that support the paracetamolinduced hypothermia and indeed the paracetamolinduced antipyresis and analgesia are centrally mediated is supported by a large volume of published literature that spans 6 decades [18][19][20][21][22][23]27,28,96,[131][132][133][134][135], which comes from direct in vivo experiments in which the pharmacological actions of paracetamol are directly correlated”

    From Paracetamol (acetaminophen): A familiar drug with an unexplained mechanism of action (2021) · cites this paper as [18]

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Authors
FELDBERG, W., & SHALIGRAM, S. V.
Affiliations
National Institute for Medical Research (GB)
Venue
British Journal of Pharmacology
Publisher
Wiley
Published
1972-12
Volume
46
Issue
4
Pages
602-618
ISSN
  • 0007-1188 (ISSN-L)
  • 1476-5381
DOI
10.1111/j.1476-5381.1972.tb06887.x
PMC
PMC1666375
OpenAlex
W2134442194
Cited by
105
References
21
Citations by year
2025: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2017: 1 · 2015: 2 · 2013: 2
FWCI
1.68
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 14475 d)
Locations
  • British Journal of Pharmacology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords
morphine, hyperglycemia, intraventricular injection, norepinephrine, epinephrine, serotonin, reserpine, pentobarbital, central nervous system, catecholamines, analgesia, pupil dilation
MeSH terms
Analgesia, Animals, Blood Glucose, Catheterization, Cats, Cerebral Ventricles, Coloring Agents, Epinephrine, Female, Hyperglycemia, Injections, Intravenous, Male, Morphine, Motor Activity, Norepinephrine, Pentobarbital, Reserpine, Serotonin, Shivering, Vocalization, Animal

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