The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Inflammatory oedema induced by synergism between calcitonin gene‐related peptide (CGRP) and mediators of increased vascular permeability
Open accessAbstract
The potent vasodilator calcitonin gene‐related peptide (CGRP, human synthetic), when mixed with histamine and injected intradermally in the rabbit, induced a marked potentiation of local oedema. CGRP also potentiated oedema induced by other mediators of increased microvascular permeability in the rabbit; bradykinin, platelet‐activating factor (Paf), C5a des Arg, N‐formylmethionyl‐leucyl‐phenylalanine (FMLP) and leukotriene B 4 (LTB 4). Substance P alone, or mixtures of substance P and CGRP, failed to induce oedema in rabbit skin. In rat skin, however, substance P induced oedema and this was potentiated by CGRP. CGRP had a protracted potentiating action following intradermal injection in the rabbit. The time for half loss of activity for CGRP was 40.1 ± 7.5 min compared to 18 ± 1 min for prostaglandin E 2 (PGE 2). No loss of potentiating activity was detected after incubation of CGRP in rabbit plasma or blood for 60 min. We postulate that endogenous CGRP, if released locally from nerve endings, could have a marked enhancing effect on oedema induced by other mediators in an inflammatory reaction.
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Citations
Cites
Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing
Rosenfeld, M. G., Mermod, J.-J., Amara, S. G., Swanson, L. W., Sawchenko, P. E., Rivier, J., Vale, W. W., & Evans, R. M. (1983) · Nature · doi:10.1038/304129a0 · Cited by 2,302
Cited by
Calcitonin Gene-Related Peptide: Physiology and Pathophysiology
Russell, F. A., King, R., Smillie, S.-J., Kodji, X., & Brain, S. D. (2014) · Physiological Reviews · doi:10.1152/physrev.00034.2013 · Cited by 1,258
Self-citationGibbins, I. L., Furness, J. B., & Costa, M. (1987) · Cell and Tissue Research · doi:10.1007/bf00218210 · Cited by 351
Modern Aspects of Cutaneous Neurogenic Inflammation
Steinhoff, M., Ständer, S., Seeliger, S., Ansel, J. C., Schmelz, M., & Luger, T. (2003) · Archives of Dermatology · doi:10.1001/archderm.139.11.1479 · Cited by 346
Peptides from the calcitonin genes: molecular genetics, structure and function
Breimer, L. H., MacIntyre, I., & Zaidi, M. (1988) · Biochemical Journal · doi:10.1042/bj2550377 · Cited by 189
Neurokinin mediation of edema and inflammation
Campos, M. M., & Calixto, J. B. (2000) · Neuropeptides · doi:10.1054/npep.2000.0823 · Cited by 102
Metadata
- Authors
- Brain, S. D., & Williams, T. J.
- Venue
- British Journal of Pharmacology
- Publisher
- Wiley
- Published
- 1985-12
- Volume
- 86
- Issue
- 4
- Pages
- 855-860
- ISSN
- 0007-1188 (ISSN-L)
- 1476-5381
- OpenAlex
- W1988325008
- Cited by
- 447
- References
- 1
- FWCI
- 5.17
- Type
- journal article
- Language
- en
- Open access
- green
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- Brain, S. D., & Williams, T. J. (1985). Inflammatory oedema induced by synergism between calcitonin gene‐related peptide (CGRP) and mediators of increased vascular permeability. British Journal of Pharmacology. https://doi.org/10.1111/j.1476-5381.1985.tb11107.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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