The DOI matches its Crossref record; 372 of the 372 references it cites were found in a registry or an index.
Calcitonin Gene-Related Peptide: Physiology and Pathophysiology
Open accessAbstract
Calcitonin gene-related peptide (CGRP) is a 37-amino acid neuropeptide. Discovered 30 years ago, it is produced as a consequence of alternative RNA processing of the calcitonin gene. CGRP has two major forms (α and β). It belongs to a group of peptides that all act on an unusual receptor family. These receptors consist of calcitonin receptor-like receptor (CLR) linked to an essential receptor activity modifying protein (RAMP) that is necessary for full functionality. CGRP is a highly potent vasodilator and, partly as a consequence, possesses protective mechanisms that are important for physiological and pathological conditions involving the cardiovascular system and wound healing. CGRP is primarily released from sensory nerves and thus is implicated in pain pathways. The proven ability of CGRP antagonists to alleviate migraine has been of most interest in terms of drug development, and knowledge to date concerning this potential therapeutic area is discussed. Other areas covered, where there is less information known on CGRP, include arthritis, skin conditions, diabetes, and obesity. It is concluded that CGRP is an important peptide in mammalian biology, but it is too early at present to know if new medicines for disease treatment will emerge from our knowledge concerning this molecule.
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Cites
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Cited by
Pathophysiology of migraine: a disorder of sensory processing
Goadsby, P. J., Holland, P. R., Martins-Oliveira, M., Hoffmann, J., Schankin, C., & Akerman, S. (2017) · Physiological Reviews · doi:10.1152/physrev.00034.2015 · Cited by 1,998
U.S. FDA Approved Drugs from 2015–June 2020: A Perspective
Bhutani, P., Joshi, G., Raja, N., Bachhav, N., Rajanna, P. K., Bhutani, H., Paul, A. T., & Kumar, R. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c01786 · Cited by 815
Maternal Mineral and Bone Metabolism During Pregnancy, Lactation, and Post-Weaning Recovery
Kovacs, C. S. (2016) · Physiological Reviews · doi:10.1152/physrev.00027.2015 · Cited by 544
CGRP and the Trigeminal System in Migraine
Iyengar, S., Johnson, K. W., Ossipov, M. H., & Aurora, S. K. (2019) · Headache: The Journal of Head and Face Pain · doi:10.1111/head.13529 · Cited by 486
Hallmarks of peripheral nerve function in bone regeneration
Tao, R., Mi, B., Hu, Y., Lin, S., Xiong, Y., Lu, X., Panayi, A. C., Li, G., & Liu, G. (2023) · Bone Research · doi:10.1038/s41413-022-00240-x · Cited by 110
Metadata
- Authors
- Russell, F. A., King, R., Smillie, S.-J., Kodji, X., & Brain, S. D.
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2014-10
- Volume
- 94
- Issue
- 4
- Pages
- 1099-1142
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W2001650386
- Cited by
- 1,258
- References
- 372
- FWCI
- 3.40
- Type
- journal article
- Language
- en
- Open access
- green
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