The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
GR43175, a selective agonist for the 5‐HT1‐like receptor in dog isolated saphenous vein
Open accessAbstract
We describe the actions of a novel and selective 5‐HT 1‐like receptor agonist, GR43175, in a range of isolated tissue preparations containing different 5‐hydroxytryptamine (5‐HT) receptor types. GR43175 was a potent agonist at 5‐HT 1‐like receptors mediating contraction of the dog isolated saphenous vein and also at those inhibiting neuronally mediated contractions in the same preparations. For both actions, GR43175 was approximately four times weaker than 5‐HT. GR43175 was devoid of agonist properties at 5‐HT 1‐like receptors mediating relaxation of the cat isolated saphenous vein. GR43175 was devoid of agonist properties at 5‐HT 2 receptors mediating contraction of the rabbit isolated aorta, pig coronary artery, greyhound coronary artery and beagle femoral artery. GR43175 was devoid of agonist properties at 5‐HT 3 receptors mediating depolarization of the rat isolated vagus nerve. The contractile response to GR43175 in the dog isolated saphenous vein was selectively antagonized by methiothepin but was resistant to antagonism by the 5‐HT 2 receptor blocking drug ketanserin and the 5‐HT 3 receptor blocking drug MDL 72222. Methiothepin antagonized the contractile action of 5‐HT and GR43175 to an equal extent suggesting that both agonists act at the same receptor. The results demonstrate that GR43175 is a highly selective agonist for the 5‐HT 1‐like receptors found in the dog saphenous vein. The absence of an action of GR43175 at 5‐HT 1‐like receptors mediating relaxation of the cat isolated saphenous vein provides further evidence that 5‐HT 1‐like receptors are heterogeneous.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine
Bradley, P. B., Engel, G., Feniuk, W., Fozard, J. R., Humphrey, P. P. A., Middlemiss, D. N., Mylecharane, E. J., Richardson, B. P., & Saxena, P. R. (1986) · Neuropharmacology · doi:10.1016/0028-3908(86)90207-8 · Cited by 1,258
Self-citationEndothelium-dependent relaxation of coronary arteries by noradrenaline and serotonin
Cocks, T. M., & Angus, J. A. (1983) · Nature · doi:10.1038/305627a0 · Cited by 844
Hoyer, D., Engel, G., & Kalkman, H. O. (1985) · European Journal of Pharmacology · doi:10.1016/0014-2999(85)90658-2 · Cited by 574
Characterization of a novel 3H-5-hydroxytryptamine binding site subtype in bovine brain membranes
Heuring, R., & Peroutka, S. (1987) · The Journal of Neuroscience · doi:10.1523/jneurosci.07-03-00894.1987 · Cited by 400
Ireland, S. J., & Tyers, M. B. (1987) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1987.tb16844.x · Cited by 278
Engel, G., G�thert, M., M�ller-Schweinitzer, E., Schlicker, E., Sistonen, L., & Stadler, P. A. (1983) · Naunyn-Schmiedeberg's Archives of Pharmacology · doi:10.1007/bf00497016 · Cited by 203
RECEPTORS FOR 5‐HYDROXYTRYPTAMINE AND NORADRENALINE IN RABBIT ISOLATED EAR ARTERY AND AORTA
Apperley, E., Humphrey, P. P. A., & Levy, G. (1976) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1976.tb10398.x · Cited by 197
Self-citationEVIDENCE FOR TWO TYPES OF EXCITATORY RECEPTOR FOR 5‐HYDROXYTRYPTAMINE IN DOG ISOLATED VASCULATURE
Apperley, E., Feniuk, W., Humphrey, P. P. A., et al. (1980) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1980.tb10410.x · Cited by 136
Self-citationKenakin, T., & Beek, D. (1980) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)32076-8 · Cited by 126
Brittain, R. T., Boutal, L., Carter, M. C., Coleman, R. A., COLLINGTON, E. W., Geisow, H. P., Hallett, P., Hornby, E. J., Humphrey, P. P. A., & Jack, D. B. (1985) · Circulation · doi:10.1161/01.cir.72.6.1208 · Cited by 85
Self-citation
Cited by
Buzzi, M. G., & Moskowitz, M. A. (1990) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1990.tb14679.x · Cited by 416
Moskowitz, M., Nozaki, K., & Kraig, R. (1993) · The Journal of Neuroscience · doi:10.1523/jneurosci.13-03-01167.1993 · Cited by 371
Bruinvels, A. T., Landwehrmeyer, B., Gustafson, E. L., Durkin, M. M., Mengod, G., Branchek, T. A., Hoyer, D., & Palacios, J. M. (1994) · Neuropharmacology · doi:10.1016/0028-3908(94)90067-1 · Cited by 349
SEROTONIN IN THE REGULATION OF BRAIN MICROCIRCULATION
COHEN, Z., BONVENTO, G., LACOMBE, P., & HAMEL, E. (1996) · Progress in Neurobiology · doi:10.1016/s0301-0082(96)00033-0 · Cited by 314
Metadata
- Authors
- Humphrey, P. P. A., Feniuk, W., Perren, M. J., Connor, H. E., Oxford, A. W., Coates, I. H., & Butina, D.
- Venue
- British Journal of Pharmacology
- Publisher
- Wiley
- Published
- 1988-08
- Volume
- 94
- Issue
- 4
- Pages
- 1123-1132
- ISSN
- 0007-1188 (ISSN-L)
- 1476-5381
- OpenAlex
- W1983664314
- Cited by
- 301
- References
- 11
- FWCI
- 11.44
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: GR43175, a selective agonist for the 5‐HT1‐like receptor in dog isolated saphenous vein. https://app.cochat.ai/papers/10.1111/j.1476-5381.1988.tb11630.x
- The paper
- Humphrey, P. P. A., Feniuk, W., Perren, M. J., Connor, H. E., Oxford, A. W., Coates, I. H., & Butina, D. (1988). GR43175, a selective agonist for the 5‐HT1‐like receptor in dog isolated saphenous vein. British Journal of Pharmacology. https://doi.org/10.1111/j.1476-5381.1988.tb11630.x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
