SEROTONIN IN THE REGULATION OF BRAIN MICROCIRCULATION

COHEN, ZVI; BONVENTO, GILLES; LACOMBE, PIERRE; HAMEL, EDITH

doi:10.1016/s0301-0082(96)00033-0

Cited by 314Barrier Structure and Function StudiesTraumatic Brain Injury and Neurovascular DisturbancesMigraine and Headache Studies

SEROTONIN IN THE REGULATION OF BRAIN MICROCIRCULATION

COHEN, ZVI, BONVENTO, GILLES, LACOMBE, PIERRE, HAMEL, EDITH·1996·Progress in Neurobiology

DOI 10.1016/s0301-0082(96)00033-0

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Abstract

Manipulation of brainstem serotonin (5-HT) raphe neurons induces significant alterations in local cerebral metabolism and perfusion. The vascular consequences of intracerebrally released 5-HT point to a major vasoconstrictor role, resulting in cerebral blood flow (CBF) decreases in several brain regions such as the neocortex. However, vasodilatations, as well as changes in blood-brain barrier (BBB) permeability, which are blocked by 5-HT receptor antagonists also can be observed. A lack of relationship between the changes in flow and metabolism indicates uncoupling between the two variables and is suggestive of a direct neurogenic control by brain intrinsic 5-HT neurons on the microvascular bed. In line with these functional data are the close associations that exist between 5-HT neurons and the microarterioles, capillaries and perivascular astrocytes of various regions but more intimately and/or more frequently so in those where CBF is altered significantly following manipulation of 5-HT neurons. The ability of the microvascular bed to respond directly to intracerebrally released 5-HT is underscored by the expression of distinct 5-HT receptors in the various cellular compartments of the microvascular bed. Thus, it appears that while some 5-HT-mediated microvascular functions involve directly the blood vessel wall, others would be relayed through the perivascular astrocyte. The strategic localization of perivascular astrocytes and the different 5-HT receptors that they harbor strongly emphasize their putative pivotal role in transmitting information between 5-HT neurons and microvessels. It is concluded that the cerebral circulation has full capacity to adequately and locally adapt brain perfusion to changes in central 5-HT neurotransmission either directly or indirectly via the neuronal-astrocytic-vascular tripartite functional unit. Dysfunctions in these neurovascular interactions might result in perfusion deficits and might be involved in specific pathological conditions.

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Because serotonin is involved in vasoconstriction, prior or recent MDMA exposure might have affected BOLD responses.
“Moreover, due to involvement of serotonin in vasoconstriction (Cohen et al. 1996), it is possible that prior or recent MDMA exposure might have affected BOLD responses.”
From Effects of MDMA on sociability and neural response to social threat and social reward (2009) · cites this paper as Cohen et al. 1996

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Authors: COHEN, Z., BONVENTO, G., LACOMBE, P., & HAMEL, E.
Affiliations: Montreal Neurological Institute and Hospital (CA)
Centre National de la Recherche Scientifique (FR)
ORCID: COHEN, ZVI
BONVENTO, GILLES
Venue: Progress in Neurobiology
Publisher: Elsevier BV
Published: 1996-11
Volume: 50
Issue: 4
Pages: 335-362
ISSN: 0301-0082 (ISSN-L)
DOI: 10.1016/s0301-0082(96)00033-0
OpenAlex: W2050297923
Cited by: 314
References: 165
Citations by year: 2026: 4 · 2025: 12 · 2024: 5 · 2023: 8 · 2022: 6 · 2021: 13 · 2020: 5 · 2019: 5 · 2018: 7 · 2017: 14 · 2016: 13 · 2015: 11 · 2014: 16 · 2013: 22 · 2012: 18
FWCI: 5.03
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Progress in Neurobiology (publishedVersion)
PubMed (publishedVersion)
Funders: Centre National de la Recherche Scientifique
Topics: Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Health Sciences › Medicine › Psychiatry and Mental health › Migraine and Headache Studies
Keywords: serotonin, cerebral microcirculation, cerebral blood flow, vasoconstriction, vasodilation, blood-brain barrier permeability, serotonin receptors, perivascular astrocytes, microvascular bed, neurovascular coupling
MeSH terms: Animals, Brain, Cerebrovascular Circulation, Humans, Microcirculation, Serotonin

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SEROTONIN IN THE REGULATION OF BRAIN MICROCIRCULATION

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