The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
A specific inhibitor of nitric oxide formation from l‐arginine attenuates endothelium‐dependent relaxation
Open accessAbstract
The role of l‐arginine in the basal and stimulated generation of nitric oxide (NO) for endothelium‐dependent relaxation was studied by use of N G‐monomethyl l‐arginine (l‐NMMA), a specific inhibitor of this pathway. l‐Arginine (10–100 μ m), but not d‐arginine (100 μ m), induced small but significant endothelium‐dependent relaxations of rings of rabbit aorta. In contrast, l‐NMMA (1–300 μ m) produced small, endothelium‐dependent contractions, while its enantiomer N G‐monomethyl‐d‐arginine (d‐NMMA; 100 μ) had no effect. l‐NMMA (1–300 μ m) inhibited endothelium‐dependent relaxations induced by acetylcholine (ACh), the calcium ionophore A23187, substance P or l‐arginine without affecting the endothelium‐independent relaxations induced by glyceryl trinitrate or sodium nitroprusside. The inhibition of endothelium‐dependent relaxation by l‐NMMA (30 μ m) was reversed by l‐arginine (3–300 μ m) but not by d‐arginine (300 μ m) or a number of close analogues (100 μ m). The release of NO induced by ACh from perfused segments of rabbit aorta was also inhibited by l‐NMMA (3–300 μ m), but not by d‐NMMA (100 μ m) and this effect of l‐NMMA was reversed by l‐arginine (3–300 μ m). These results support the proposal that l‐arginine is the physiological precursor for the basal and stimulated generation of NO for endothelium‐dependent relaxation.
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Cites
Furchgott, R. F., & Zawadzki, J. V. (1980) · Nature · doi:10.1038/288373a0 · Cited by 12,064
Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
Palmer, R. M. J., Ferrige, A. G., & Moncada, S. (1987) · Nature · doi:10.1038/327524a0 · Cited by 10,704
Self-citationVascular endothelial cells synthesize nitric oxide from L-arginine
Palmer, R. M. J., Ashton, D. S., & Moncada, S. (1988) · Nature · doi:10.1038/333664a0 · Cited by 4,769
Self-citationSuperoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor
Gryglewski, R. J., Palmer, R. M. J., & Moncada, S. (1986) · Nature · doi:10.1038/320454a0 · Cited by 2,400
Self-citationMacrophage cytotoxicity: role for L-arginine deiminase and imino nitrogen oxidation to nitrite
Hibbs, J. B., Taintor, R. R., & Vavrin, Z. (1987) · Science · doi:10.1126/science.2432665 · Cited by 1,527
Palmer, R. M. J., Rees, D. D., Ashton, D. S., & Moncada, S. (1988) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(88)81362-7 · Cited by 1,349
Self-citationMartin, W., Villani, G. M., Jothianandan, D., & Furchgott, R. F. (1985) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)20898-9 · Cited by 1,257
Radomski, M. W., Palmer, R. M. J., & Moncada, S. (1987) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1987.tb11367.x · Cited by 1,164
Self-citationHibbs, J. B., Vavrin, Z., & Taintor, R. R. (1987) · The Journal of Immunology · doi:10.4049/jimmunol.138.2.550 · Cited by 935
Endothelium‐dependent hyperpolarization of canine coronary smooth muscle
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Cited by
Release of endothelin from the porcine aorta. Inhibition by endothelium-derived nitric oxide.
Boulanger, C., & Lüscher, T. F. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114477 · Cited by 1,045
The discovery of nitric oxide and its role in vascular biology
Moncada, S., & Higgs, E. A. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706458 · Cited by 863
Self-citationEndogenous nitric oxide: physiology, pathology and clinical relevance
MONCADA, S., & HIGGS, E. A. (1991) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1991.tb01383.x · Cited by 759
Self-citationAge-Related Reduction of NO Availability and Oxidative Stress in Humans
Taddei, S., Virdis, A., Ghiadoni, L., Salvetti, G., Bernini, G., Magagna, A., & Salvetti, A. (2001) · Hypertension · doi:10.1161/01.hyp.38.2.274 · Cited by 664
Control of cardiac muscle cell function by an endogenous nitric oxide signaling system.
Balligand, J. L., Kelly, R. A., Marsden, P. A., Smith, T. W., & Michel, T. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.1.347 · Cited by 658
Metadata
- Authors
- Rees, D. D., Palmer, R. M. J., Hodson, H. F., & Moncada, S.
- Venue
- British Journal of Pharmacology
- Publisher
- Wiley
- Published
- 1989-02
- Volume
- 96
- Issue
- 2
- Pages
- 418-424
- ISSN
- 0007-1188 (ISSN-L)
- 1476-5381
- OpenAlex
- W2083565776
- Cited by
- 850
- References
- 24
- FWCI
- 58.03
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Rees, D. D., Palmer, R. M. J., Hodson, H. F., & Moncada, S. (1989). A specific inhibitor of nitric oxide formation from l‐arginine attenuates endothelium‐dependent relaxation. British Journal of Pharmacology. https://doi.org/10.1111/j.1476-5381.1989.tb11833.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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