The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
7‐Nitro indazole, an inhibitor of nitric oxide synthase, exhibits anti‐nociceptive activity in the mouse without increasing blood pressure
Open accessAbstract
7‐Nitro indazole (7‐NI) inhibits mouse cerebellar nitric oxide synthase (NOS) in vitro with an IC 50 of 0.47 μ m. Following i.p. administration in mice, 7‐NI (10–50 mg kg−1) produces dose‐related anti‐nociception as evidenced by an inhibition of late phase (15–30 min) but not early phase (0–5 min) hindpaw licking time following subplantar injection of formalin (10 μl, 5% v/v). The ED 50 for this effect was 26 mg kg−1 (equivalent to 159.5 μmol kg−1). Similar i.p. administration of 7‐NI (20 and 80 mg kg−1) in urethane‐anaesthetized mice failed to increase MAP. Thus, 7‐NI is a novel inhibitor of NOS which exhibits selectivity for the brain enzyme. Accordingly, 7‐NI may be a useful starting point for the development of selective, centrally acting NOS inhibitors devoid of cardiovascular side effects and as a tool to study the central pharmacological effects of nitric oxide (NO).
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“Other recent studies show improved endothelial function and insulin sensitivity in patients with impaired glucose uptake and metabolic syndrome (6.6 g/day l-arginine for 2 wk) (663) and improved endothelial function and decreased homocysteine levels in patients with elevated blood pressure and hyperhomocysteinuria (2.4 g/day for 4 wk) (781).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [663]
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Cites
Glutamate, nitric oxide and cell-cell signalling in the nervous system
Garthwaite, J. (1991) · Trends in Neurosciences · doi:10.1016/0166-2236(91)90022-m · Cited by 2,401
Role of endothelium-derived nitric oxide in the regulation of blood pressure.
Rees, D. D., Palmer, R. M. J., & Moncada, S. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.9.3375 · Cited by 1,827
l ‐NG‐nitro arginine methyl ester exhibits antinociceptive activity in the mouse
Moore, P. K., Oluyomi, A. O., Babbedge, R. C., Wallace, P., & Hart, S. L. (1991) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1991.tb12153.x · Cited by 471
Self-citationNitric oxide synthase: Irreversible inhibition by L-N -Nitroarginine in brain and
Dwyer, M. A., Bredt, D. S., & Snyder, S. H. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(91)90403-t · Cited by 360
Haley, J. E., Dickenson, A. H., & SCHACHTER, M. (1992) · Neuropharmacology · doi:10.1016/0028-3908(92)90175-o · Cited by 289
Morgan, C. V. J., Babbedge, R. C., Gaffen, Z. A., et al. (1992) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1992.tb14362.x · Cited by 34
Self-citationHart, S. L., Oluyomi, A. O., Wallace, P., et al. (1990) · European Journal of Pharmacology · doi:10.1016/0014-2999(90)94577-k · Cited by 5
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Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation
Tejero, J., Shiva, S., & Gladwin, M. T. (2019) · Physiological Reviews · doi:10.1152/physrev.00036.2017 · Cited by 541
Yoshida, T., Limmroth, V., Irikura, K., & Moskowitz, M. A. (1994) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1994.123 · Cited by 286
Klatt, P., Schmid, M., Leopold, E., Schmidt, K., Werner, E. R., & Mayer, B. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36726-1 · Cited by 219
Toda, N., Ayajiki, K., & Okamura, T. (2009) · Journal of Hypertension · doi:10.1097/hjh.0b013e32832e8ddf · Cited by 56
Yu, L., Derrick, M., Ji, H., Silverman, R. B., Whitsett, J., Vásquez-Vivar, J., & Tan, S. (2011) · Developmental Neuroscience · doi:10.1159/000327244 · Cited by 38
Metadata
- Authors
- Moore, P. K., Babbedge, R. C., Wallace, P., Gaffen, Z. A., & Hart, S. L.
- Affiliations
- University of London (GB)
- Corresponding author
- Moore, P.K.
- Venue
- British Journal of Pharmacology
- Publisher
- Wiley
- Published
- 1993-02
- Volume
- 108
- Issue
- 2
- Pages
- 296-297
- ISSN
- 0007-1188 (ISSN-L)
- 1476-5381
- PMC
- PMC1907983
- OpenAlex
- W2007727357
- Cited by
- 424
- References
- 7
- Citations by year
- 2026: 4 · 2025: 3 · 2023: 4 · 2022: 1 · 2021: 2 · 2020: 2 · 2018: 3 · 2017: 3 · 2016: 9 · 2015: 4 · 2014: 8 · 2013: 5 · 2012: 8
- FWCI
- 21.32
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal of Pharmacology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medical Research Council
- Topics
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- 7-nitroindazole, nitric oxide synthase inhibitors, antinociception, formalin test, blood pressure, central nervous system, nitric oxide, analgesia
- MeSH terms
- Amino Acid Oxidoreductases, Analgesics, Animals, Blood Pressure, Cerebellum, Formaldehyde, Indazoles, Male, Mice, Inbred Strains, Sensitivity and Specificity, Nitric Oxide Synthase, Mice, In Vitro Techniques
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