Control of systemic and pulmonary blood pressure by nitric oxide formed through neuronal nitric oxide synthase
Abstract
Nitric oxide formed by neuronal nitric oxide synthase (nNOS) in the brain, autonomic inhibitory (nitrergic) nerves, and heart plays important roles in the control of blood pressure. Activation of nitrergic nerves innervating the systemic vasculature elicits vasodilatation, decreases peripheral resistance, and lowers blood pressure. Impairment of nitrergic nerve function, as well as endothelial dysfunction, results in systemic and pulmonary hypertension and decreased regional blood flow. Blockade of nNOS activity in the brain, particularly the medulla and hypothalamus, causes systemic hypertension. Under hypertensive states, such as those in spontaneously hypertensive and Dahl salt-sensitive rats, the expression of the nNOS gene in the brain is increased; this appears to counteract the activated sympathetic function in the vasomotor center. The present article summarizes information concerning the modulation of systemic and pulmonary hypertension through nNOS-derived nitric oxide produced in the brain and periphery.
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NOS1 activity in the medulla and hypothalamus is important for systemic regulation of blood pressure.
“NOS1 activity in the medulla and hypothalamus is important for systemic regulation of blood pressure [104-107]”
From Regulation of obesity and insulin resistance by nitric oxide (2014) · cites this paper as [107]
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Functional Study on Nitroxidergic Nerve in Isolated Dog Pulmonary Arteries and Veins
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Interaction of central Ang II and NO on the cardiac sympathetic afferent reflex in dogs
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Maturation alters cerebral NOS kinetics in the spontaneously hypertensive rat
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Nitric oxide synthases: regulation and function
Forstermann, U., & Sessa, W. C. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehr304 · Cited by 4,409 · see citing works
Regulation of obesity and insulin resistance by nitric oxide
Sansbury, B. E., & Hill, B. G. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.05.016 · Cited by 274 · see citing works
“regulation of blood pressure [104–107]; and the nitrergic nerves containing NOS1 are responsible for penile erection [99,108].”
BackgroundDobrynina, L. A., Zabitova, M. R., Kalashnikova, L. A., Gnedovskaya, E. V., & Piradov, M. A. (2018) · Acta Naturae · doi:10.32607/20758251-2018-10-2-4-15 · Cited by 11 · see citing works
- Authors
- Toda, N., Ayajiki, K., & Okamura, T.
- Affiliations
- Shiga University of Medical Science (JP)
- Hyogo University of Health Sciences (JP)
- Corresponding author
- Toda, Noboru
- ORCID
- Toda, Noboru
- Venue
- Journal of Hypertension
- Published
- 2009-10
- Volume
- 27
- Issue
- 10
- Pages
- 1929-1940
- ISSN
- 0263-6352 (ISSN-L)
- OpenAlex
- W2015338632
- Cited by
- 56
- References
- 116
- Citations by year
- 2025: 2 · 2024: 4 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 4 · 2017: 4 · 2016: 1 · 2015: 4 · 2014: 7 · 2013: 3 · 2012: 4
- FWCI
- 0.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Keywords
- nitric oxide, neuronal nitric oxide synthase, blood pressure regulation, pulmonary hypertension, systemic hypertension, nitrergic neurons, vasodilation, systemic vascular resistance, endothelial dysfunction, medulla, hypothalamus, sympathetic nervous system, vasomotor center, spontaneously hypertensive rats, Dahl salt-sensitive rats
- MeSH terms
- Animals, Blood Pressure, Humans, Hypertension, Hypertension, Pulmonary, Nitric Oxide, Nitric Oxide Synthase Type I
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