Cited by 56Nitric Oxide and Endothelin EffectsBlood Pressure and Hypertension StudiesHeart Rate Variability and Autonomic Control

Control of systemic and pulmonary blood pressure by nitric oxide formed through neuronal nitric oxide synthase

Toda, Noboru, Ayajiki, Kazuhide, Okamura, Tomio·2009·Journal of Hypertension

Abstract

Nitric oxide formed by neuronal nitric oxide synthase (nNOS) in the brain, autonomic inhibitory (nitrergic) nerves, and heart plays important roles in the control of blood pressure. Activation of nitrergic nerves innervating the systemic vasculature elicits vasodilatation, decreases peripheral resistance, and lowers blood pressure. Impairment of nitrergic nerve function, as well as endothelial dysfunction, results in systemic and pulmonary hypertension and decreased regional blood flow. Blockade of nNOS activity in the brain, particularly the medulla and hypothalamus, causes systemic hypertension. Under hypertensive states, such as those in spontaneously hypertensive and Dahl salt-sensitive rats, the expression of the nNOS gene in the brain is increased; this appears to counteract the activated sympathetic function in the vasomotor center. The present article summarizes information concerning the modulation of systemic and pulmonary hypertension through nNOS-derived nitric oxide produced in the brain and periphery.

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Crossref · 10.1097/hjh.0b013e32832e8ddf

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  • NOS1 activity in the medulla and hypothalamus is important for systemic regulation of blood pressure.

    “NOS1 activity in the medulla and hypothalamus is important for systemic regulation of blood pressure [104-107]”

    From Regulation of obesity and insulin resistance by nitric oxide (2014) · cites this paper as [107]

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Authors
Toda, N., Ayajiki, K., & Okamura, T.
Affiliations
  • Shiga University of Medical Science (JP)
  • Hyogo University of Health Sciences (JP)
Corresponding author
Toda, Noboru
Venue
Journal of Hypertension
Published
2009-10
Volume
27
Issue
10
Pages
1929-1940
ISSN
0263-6352 (ISSN-L)
OpenAlex
W2015338632
Cited by
56
References
116
Citations by year
2025: 2 · 2024: 4 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 4 · 2017: 4 · 2016: 1 · 2015: 4 · 2014: 7 · 2013: 3 · 2012: 4
FWCI
0.62
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Hypertension (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Keywords
nitric oxide, neuronal nitric oxide synthase, blood pressure regulation, pulmonary hypertension, systemic hypertension, nitrergic neurons, vasodilation, systemic vascular resistance, endothelial dysfunction, medulla, hypothalamus, sympathetic nervous system, vasomotor center, spontaneously hypertensive rats, Dahl salt-sensitive rats
MeSH terms
Animals, Blood Pressure, Humans, Hypertension, Hypertension, Pulmonary, Nitric Oxide, Nitric Oxide Synthase Type I

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