The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
THE ACTION OF MORPHINE AND RELATED SUBSTANCES ON CONTRACTION AND ON ACETYLCHOLINE OUTPUT OF COAXIALLY STIMULATED GUINEA‐PIG ILEUM
Open accessAbstract
Morphine depresses the twitch and tetanus of stimulated guinea‐pig ileum by reducing acetylcholine released from cholinergic nerve endings. Acetylcholine output per shock falls to roughly the same residual amount at varying stimulation rates. Since normal output per shock declines with increasing stimulus frequency, the proportionate effect of morphine diminishes as stimulus frequency rises. Acute “tolerance” to morphine and a state of “morphine‐dependence” can be produced. Phenadoxone, dihydromorphinone, metopon, methadone, and heroin are more active, codeine and pethidine less active, than morphine. Nalorphine also depresses the twitch and can desensitize the gut both to itself and to morphine.
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Citations
Cites
Identification of two related pentapeptides from the brain with potent opiate agonist activity
Hughes, J., Smith, T. W., Kosterlitz, H. W., Fothergill, L. A., Morgan, B. A., & Morris, H. R. (1975) · Nature · doi:10.1038/258577a0 · Cited by 3,806
Cited by
Enkephalin-like immunoreactivity in gland cells and nerve terminals of the adrenal medulla
Schultzberg, M., Lundberg, J. M., Ho¨kfelt, T., Terenius, L., Brandt, J., Elde, R. P., & Goldstein, M. (1978) · Neuroscience · doi:10.1016/0306-4522(78)90137-9 · Cited by 555
Review article: roles played by 5‐hydroxytryptamine in the physiology of the bowel
Gershon, M. D. (1999) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.1999.00002.x-i2 · Cited by 466
Pancreatic Polypeptide: A Hormone Under Vagal Control
Schwartz, T. W. (1983) · Gastroenterology · doi:10.1016/s0016-5085(83)80027-4 · Cited by 426
Opioid receptors in the gastrointestinal tract
Holzer, P. (2009) · Regulatory Peptides · doi:10.1016/j.regpep.2009.03.012 · Cited by 377
Metadata
- Authors
- PATON, W. D. M.
- Venue
- British Journal of Pharmacology
- Publisher
- Wiley
- Published
- 1997-02
- Volume
- 120
- Issue
- S1
- Pages
- 123-131
- ISSN
- 0007-1188 (ISSN-L)
- 1476-5381
- OpenAlex
- W2051309246
- Cited by
- 625
- References
- 1
- FWCI
- 3.04
- Type
- journal article
- Language
- en
- Open access
- bronze
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- PATON, W. D. M. (1997). THE ACTION OF MORPHINE AND RELATED SUBSTANCES ON CONTRACTION AND ON ACETYLCHOLINE OUTPUT OF COAXIALLY STIMULATED GUINEA‐PIG ILEUM. British Journal of Pharmacology. https://doi.org/10.1111/j.1476-5381.1997.tb06787.x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
