The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Opioid receptors in the gastrointestinal tract
Open accessAbstract
Opium is arguably one of the oldest herbal medicines, being used as analgesic, sedative and antidiarrheal drug for thousands of years. These effects mirror the actions of the endogenous opioid system and are mediated by the principal μ-, κ- and δ-opioid receptors. In the gut, met-enkephalin, leu-enkephalin, β-endorphin and dynorphin occur in both neurons and endocrine cells. When released, opioid peptides activate opioid receptors on the enteric circuitry controlling motility and secretion. As a result, inhibition of gastric emptying, increase in sphincter tone, induction of stationary motor patterns and blockade of peristalsis ensue. Together with inhibition of ion and fluid secretion, these effects cause constipation, one of the most frequent and troublesome adverse reactions of opioid analgesic therapy. Although laxatives are most frequently used to ameliorate opioid-induced bowel dysfunction, their efficacy is unsatisfactory. Specific antagonism of peripheral opioid receptors is a more rational approach. This goal is addressed by the use of opioid receptor antagonists with limited absorption such as oral prolonged-release naloxone and opioid receptor antagonists that do not penetrate the blood-brain barrier such as methylnaltrexone and alvimopan. Preliminary evidence indicates that peripherally restricted opioid receptor antagonists may act as prokinetic drugs in their own right.
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Cites
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Cited by
Zaborin, A., Smith, D., Garfield, K., Quensen, J., Shakhsheer, B., Kade, M., Tirrell, M., Tiedje, J., Gilbert, J. A., Zaborina, O., et al. (2014) · mBio · doi:10.1128/mbio.01361-14 · Cited by 367
Eluxadoline for Irritable Bowel Syndrome with Diarrhea
Lembo, A. J., Lacy, B. E., Zuckerman, M. J., Schey, R., Dove, L. S., Andrae, D. A., Davenport, J. M., McIntyre, G., Lopez, R., Turner, L., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1505180 · Cited by 334
Microbiota-modulated CART + enteric neurons autonomously regulate blood glucose
Muller, P. A., Matheis, F., Schneeberger, M., Kerner, Z., Jové, V., & Mucida, D. (2020) · Science · doi:10.1126/science.abd6176 · Cited by 154
Safety of Eluxadoline in Patients with Irritable Bowel Syndrome with Diarrhea
Cash, B. D., Lacy, B. E., Schoenfeld, P. S., Dove, L. S., & Covington, P. S. (2017) · American Journal of Gastroenterology · doi:10.1038/ajg.2016.542 · Cited by 88
Nutritional implications of opioid use disorder: A guide for drug treatment providers
Chavez, M. N., & Rigg, K. K. (2020) · Psychology of Addictive Behaviors · doi:10.1037/adb0000575 · Cited by 38
Metadata
- Authors
- Holzer, P.
- Venue
- Regulatory Peptides
- Publisher
- Elsevier BV
- Published
- 2009-06
- Volume
- 155
- Issue
- 1-3
- Pages
- 11-17
- ISSN
- 0167-0115 (ISSN-L)
- OpenAlex
- W1986654088
- Cited by
- 377
- References
- 52
- FWCI
- 5.39
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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