The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Prognostic indicators in hepatocellular carcinoma: a systematic review of 72 studies
Open accessAbstract
Background: Although there are many studies of the predictors of death in hepatocellular carcinoma (HCC), most combine patients with and without cirrhosis and many combine those with compensated and decompensated cirrhosis. Objective: To perform a systematic review of the literature evaluating the predictors of death in patients with cirrhosis and HCC and to evaluate whether the predictors differ between patients with compensated and decompensated cirrhosis. Methods: Inclusion criteria: (i) publication in English, (ii) adult patients, (c) >80% of the patients had cirrhosis, (iv) follow‐up >6 months and (v) multivariable analysis. Quality was based on the accepted quality criteria for prognostic studies. Results: Of the 1106 references obtained, 947 were excluded because they did not meet the inclusion criteria. A total of 23 968 patients were included in 72 studies (median, 177/study); 77% male, median age 64, 55% Child–Pugh class A. The most robust predictors of death were portal vein thrombosis, tumour size, α‐foetoprotein and Child–Pugh class. Sensitivity analysis using only 15 ‘good’ studies and 22 studies in which all patients had cirrhosis yielded the same variables. In the studies including mostly compensated or decompensated patients, the predictors were both liver and tumour related. However, these studies were few and the results were not robust. Conclusions: This systematic review of 72 studies shows that the most robust predictors of death in patients with cirrhosis and HCC are tumour related and liver related. Future prognostic studies should include these predictors and should be performed in specific patient populations to determine whether specific prognostic indicators are more relevant at different stages of cirrhosis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Mazzaferro, V., Regalia, E., Doci, R., Andreola, S., Pulvirenti, A., Bozzetti, F., Montalto, F., Ammatuna, M., Morabito, A., & Gennari, L. (1996) · New England Journal of Medicine · doi:10.1056/nejm199603143341104 · Cited by 7,186
Clinical Management of Hepatocellular Carcinoma. Conclusions of the Barcelona-2000 EASL Conference
Bruix, J., Sherman, M., Llovet, J. M., Beaugrand, M., Lencioni, R., Burroughs, A. K., Christensen, E., Pagliaro, L., Colombo, M., & Rodés, J. (2001) · Journal of Hepatology · doi:10.1016/s0168-8278(01)00130-1 · Cited by 4,089
Okuda, K., Ohtsuki, T., Obata, H., Tomimatsu, M., Okazaki, N., Hasegawa, H., Nakajima, Y., & Ohnishi, K. (1985) · Cancer · doi:10.1002/1097-0142(19850815)56:4<918::aid-cncr2820560437>3.0.co;2-e · Cited by 1,931
Assessing the Generalizability of Prognostic Information
Justice, A. C., Covinsky, K. E., & Berlin, J. A. (1999) · Annals of Internal Medicine · doi:10.7326/0003-4819-130-6-199903160-00016 · Cited by 1,160
Laupacis, A. (1997) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1997.03540300056034 · Cited by 793
Sangiovanni, A., Del Ninno, E., Fasani, P., De Fazio, C., Ronchi, G., Romeo, R., Morabito, A., de Franchis, R., & Colombo, M. (2004) · Gastroenterology · doi:10.1053/j.gastro.2003.12.049 · Cited by 600
A new prognostic classification for predicting survival in patients with hepatocellular carcinoma
Chevret, S., Trinchet, J.-C., Mathieu, D., Rached, A. A., Beaugrand, M., & Chastang, C. (1999) · Journal of Hepatology · doi:10.1016/s0168-8278(99)80173-1 · Cited by 512
Prospective validation of the Barcelona Clinic Liver Cancer staging system
Cillo, U., Vitale, A., Grigoletto, F., Farinati, F., Brolese, A., Zanus, G., Neri, D., Boccagni, P., Srsen, N., D'Amico, F., et al. (2006) · Journal of Hepatology · doi:10.1016/j.jhep.2005.12.015 · Cited by 425
Early detection of hepatocellular carcinoma in patients with chronic type B hepatitis
Liaw, Y.-F., Tai, D.-I., Chu, C.-M., Lin, D.-Y., Sheen, I.-S., Chen, T.-J., & Pao, C. C. (1986) · Gastroenterology · doi:10.1016/0016-5085(86)90919-4 · Cited by 309
Garcia-Tsao, G., Bosch, J., & Groszmann, R. J. (2008) · Hepatology · doi:10.1002/hep.22273 · Cited by 274
Self-citation
Cited by
Cabibbo, G., Enea, M., Attanasio, M., Bruix, J., Craxì, A., & Cammà, C. (2010) · Hepatology · doi:10.1002/hep.23485 · Cited by 473
Molecular Classification and Novel Targets in Hepatocellular Carcinoma: Recent Advancements
Hoshida, Y., Toffanin, S., Lachenmayer, A., Villanueva, A., Minguez, B., & Llovet, J. (2010) · Seminars in Liver Disease · doi:10.1055/s-0030-1247131 · Cited by 310
Lyu, N., Wang, X., Li, J.-B., Lai, J.-F., Chen, Q.-F., Li, S.-L., Deng, H.-J., He, M., Mu, L.-W., & Zhao, M. (2022) · Journal of Clinical Oncology · doi:10.1200/jco.21.01963 · Cited by 291
Pompili, M., Saviano, A., de Matthaeis, N., Cucchetti, A., Ardito, F., Federico, B., Brunello, F., Pinna, A. D., Giorgio, A., Giulini, S. M., et al. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.03.009 · Cited by 285
Tateishi, R., Okanoue, T., Fujiwara, N., Okita, K., Kiyosawa, K., Omata, M., Kumada, H., Hayashi, N., & Koike, K. (2015) · Journal of Gastroenterology · doi:10.1007/s00535-014-0973-8 · Cited by 170
Metadata
- Authors
- Tandon, P., & Garcia‐Tsao, G.
- Venue
- Liver International
- Publisher
- Wiley
- Published
- 2009-03-10
- Volume
- 29
- Issue
- 4
- Pages
- 502-510
- ISSN
- 0106-9543 (ISSN-L)
- 1478-3223
- 1478-3231
- OpenAlex
- W1544233162
- Cited by
- 354
- References
- 31
- FWCI
- 2.39
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Prognostic indicators in hepatocellular carcinoma: a systematic review of 72 studies. https://app.cochat.ai/papers/10.1111/j.1478-3231.2008.01957.x
- The paper
- Tandon, P., & Garcia‐Tsao, G. (2009). Prognostic indicators in hepatocellular carcinoma: a systematic review of 72 studies. Liver International. https://doi.org/10.1111/j.1478-3231.2008.01957.x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
