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Cited by 600

The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.

Increased survival of cirrhotic patients with a hepatocellular carcinoma detected during surveillance☆

Open access
Sangiovanni, Angelo, Del Ninno, Ersilio, Fasani, Pierangelo, De Fazio, Cristina, Ronchi, Guido, Romeo, Raffaella, Morabito, Alberto, de Franchis, Roberto, Colombo, Massimo·2004·Gastroenterology
DOI 10.1053/j.gastro.2003.12.049
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Abstract

BACKGROUND & AIMS: Significant improvements in management of hepatocellular carcinoma (HCC) have occurred in the last years, but their impact on surveillance outcome is unknown. To clarify this, we compared survival of HCC patients identified along 3 consecutive quinquennia of surveillance. METHODS: A cohort of 417 HCC-free outpatients with compensated cirrhosis was prospectively followed for 148 months (range, 1-213 months) with periodic ultrasound examinations. RESULTS: HCC developed in 112 patients, at a 3.4% rate per year, and was the prime cause of death (n = 54). Forty-six (41%) patients had a single tumor, with a mean size of 3.7 cm, 3.0 cm, and 2.2 cm in the 3 quinquennia (first vs. second: ns; first vs. third: P = 0.017; second vs. third: P = 0.02), and 38 (44%) underwent radical therapy. Mortality rates in HCC patients fell from 45% in the first quinquennium to 37% in the second and 10% in the third (first vs. second: ns; first vs. third: P = 0.0009; second vs. third: P = 0.018) in parallel with a reduction in yearly mortality of treated patients (34%, 28%, and 5%, respectively; first vs. second: ns; second vs. third: P = 0.036; first vs. third: P = 0.0024). After stratification for quinquennium, tumor staging, according to Cancer of the Liver Italian Program (CLIP), was the only independent predictor of survival (P = 0.015). CONCLUSIONS: Cirrhotic patients developing a HCC during the last 5 years of surveillance survived longer than previously, as a consequence of improved management of the tumor and complications of cirrhosis.

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Metadata

Authors
Sangiovanni, A., Del Ninno, E., Fasani, P., De Fazio, C., Ronchi, G., Romeo, R., Morabito, A., de Franchis, R., & Colombo, M.
Venue
Gastroenterology
Publisher
Elsevier BV
Published
2004-04
Volume
126
Issue
4
Pages
1005-1014
ISSN
0016-5085 (ISSN-L)
DOI
10.1053/j.gastro.2003.12.049
OpenAlex
W2131212067
Cited by
600
References
23
FWCI
21.42
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Increased survival of cirrhotic patients with a hepatocellular carcinoma detected during surveillance☆. https://app.cochat.ai/papers/10.1053/j.gastro.2003.12.049
The paper
Sangiovanni, A., Del Ninno, E., Fasani, P., De Fazio, C., Ronchi, G., Romeo, R., Morabito, A., de Franchis, R., & Colombo, M. (2004). Increased survival of cirrhotic patients with a hepatocellular carcinoma detected during surveillance☆. Gastroenterology. https://doi.org/10.1053/j.gastro.2003.12.049

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.