Walking and Non‐HDL‐C in Adults: A Meta‐Analysis of Randomized Controlled Trials
Open accessAbstract
An elevated level of non‐high‐density lipoprotein cholesterol (non‐HDL‐C) is a major risk factor for cardiovascular disease. The purpose of this study was to use the meta‐analytic approach to examine the effects of walking on non‐HDL‐C in adults. Twenty‐two randomized controlled trials representing 30 outcomes from 948 subjects (573 exercise, 375 control) met our inclusion criteria. Across all designs and categories, random effects modeling resulted in a significantly greater decrease in the walking group when compared with the control group of approximately 4% for non‐HDL‐C (± standard error of the mean, −5.6±1.8 mg/dL, 95% confidence interval, −8.8 to −2.4 mg/dL). Meta‐regression showed a statistically significant association between changes in non‐HDL‐C and the year of publication, with greater reductions associated with more recent publication year (R2=0.23, p=0.005). The results of this meta‐analytic review suggest that walking reduces non‐HDL‐C in adult humans.
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A previous meta-analysis reported that walking reduced adult non-HDL-C by 4%.
“previous meta-analysis reported that walking reduced adult non-HDL-C by 4% [58].”
From Effects of aerobic exercise on lipids and lipoproteins (2017) · cites this paper as [58]
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Effects of aerobic exercise on lipids and lipoproteins
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- Authors
- Kelley, G. A., Kelley, K. S., & Tran, Z. V.
- Affiliations
- West Virginia University (US)
- National Jewish Health (US)
- Venue
- Preventive Cardiology
- Publisher
- Wiley
- Published
- 2005-03
- Volume
- 8
- Issue
- 2
- Pages
- 102-107
- ISSN
- 1520-037X (ISSN-L)
- 1751-7141
- PMC
- PMC2447860
- OpenAlex
- W2136946085
- Cited by
- 46
- References
- 56
- Citations by year
- 2025: 2 · 2024: 2 · 2021: 2 · 2020: 2 · 2018: 2 · 2017: 4 · 2016: 3 · 2015: 3 · 2014: 7 · 2013: 6 · 2012: 1
- FWCI
- 0.21
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Preventive Cardiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (R01HL069802)
- Topics
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- walking, non-HDL cholesterol, physical activity, cardiovascular risk factors, lipid lowering
- MeSH terms
- Adult, Body Composition, Cardiovascular Diseases, Female, Humans, Cholesterol, LDL, Male, Middle Aged, Risk Factors, Walking
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