The DOI matches its Crossref record; 15 of the 17 references it cites were found in a registry or an index.
Proteomic analysis of normal human urinary proteins isolated by acetone precipitation or ultracentrifugation
Open accessAbstract
Background Proteomic techniques have recently become available for large-scale protein analysis. The utility of these techniques in identification of urinary proteins is poorly defined. We constructed a proteome map of normal human urine as a reference protein database by using two differential fractionated techniques to isolate the proteins.Methods Proteins were isolated from urine obtained from normal human volunteers by acetone precipitation or ultracentrifugation, separated by two-dimensional polyacrylamide gel electrophoresis (2D-PAGE) and identified by matrix-assisted laser desorption ionization-time-of-flight (MALDI-TOF) mass spectrometry followed by peptide mass fingerprinting.Results A total of 67 protein forms of 47 unique proteins were identified, including transporters, adhesion molecules, complement, chaperones, receptors, enzymes, serpins, cell signaling proteins and matrix proteins. Acetone precipitated more acidic and hydrophilic proteins, whereas ultracentrifugation fractionated more basic, hydrophobic, and membrane proteins. Bioinformatic analysis predicted glycosylation to be the most common explanation for multiple forms of the same protein.Conclusions Combining two differential isolation techniques magnified protein identification from human urine. Proteomic analysis of urinary proteins is a promising tool to study renal physiology and pathophysiology and to determine biomarkers of renal disease.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“It contains ions, amino acids, enzymes, serpins, adhesion molecules, hundreds of different small proteins and a multiple of other organic molecules with a maximal molecular diameter of 4.4 nm, as well as cell debris and nuclei [78].”
From Fourfold increase in pumpkin yield in response to low-dosage root zone application of urine-enhanced biochar to a fertile tropical soil (2015) · cites this paper as [78]
Citations
Cites
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302
Mass Spectrometric Sequencing of Proteins from Silver-Stained Polyacrylamide Gels
Shevchenko, A., Wilm, M. S., Vorm, O., & Mann, M. (1996) · Analytical Chemistry · doi:10.1021/ac950914h · Cited by 8,996
Protein Purification: Principles and Practice
Scopes, R. K. (1982) · Cited by 1,029
Klose, J., & Kobalz, U. (1995) · Electrophoresis · doi:10.1002/elps.11501601175 · Cited by 714
The dynamic range of protein expression: A challenge for proteomic research
Corthals, G. L., Wasinger, V. C., Hochstrasser, D. F., & Sanchez, J. (2000) · Electrophoresis · doi:10.1002/(sici)1522-2683(20000401)21:6 · Cited by 622
Protein purification: Principles and practice
Jakoby, W. B. (1983) · Analytical Biochemistry · doi:10.1016/0003-2697(83)90759-5 · Cited by 420
Scopes, R. K. (1994) · Springer eBooks · doi:10.1007/978-1-4757-2333-5 · Cited by 298
Fluoride Exposure Attenuates Expression of Streptococcus pyogenes Virulence Factors
Thongboonkerd, V., Luengpailin, J., Cao, J., Pierce, W. M. J., Cai, J., Klein, J. B., & Doyle, R. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200746200 · Cited by 101
Self-citationDetection of Na+ Transporter Proteins in Urine
McKEE, J. A., KUMAR, S., ECELBARGER, C. A., Fernández‐Llama, P., Terris, J. M., & Knepper, M. A. (2000) · Journal of the American Society of Nephrology · doi:10.1681/asn.v11112128 · Cited by 90
Ohkaru, Y., Asayama, K., Ishii, H., Nishimura, S., Sunahara, N., Tanaka, T., & Kawamura, K. (1995) · Journal of Immunological Methods · doi:10.1016/0022-1759(94)00248-u · Cited by 88
Research works printed but not linked: 2
- Harry, 2000, Proteomics: Capacity versus utility, Electrophoresis, 21, 1071, 10.1002/(SICI)1522-2683(20000401)21:6<1071::AID-ELPS1071>3.0.CO;2-M · DOI
- Corthals, 2000, The dynamic range of protein expression: A challenge for proteomic research, Electrophoresis, 21, 1104, 10.1002/(SICI)1522-2683(20000401)21:6<1104::AID-ELPS1104>3.0.CO;2-C · DOI
Cited by
Sorted by citations
Adachi, J., Kumar, C., Zhang, Y., Olsen, J. V., & Mann, M. (2006) · Genome biology · doi:10.1186/gb-2006-7-9-r80 · Cited by 655
Human body fluid proteome analysis
Hu, S., Loo, J. A., & Wong, D. T. (2006) · PROTEOMICS · doi:10.1002/pmic.200600284 · Cited by 535
Naturally Occurring Human Urinary Peptides for Use in Diagnosis of Chronic Kidney Disease
Good, D. M., Zürbig, P., Argilés, À., Bauer, H. W., Behrens, G., Coon, J. J., Dakna, M., Decramer, S., Delles, C., Dominiczak, A. F., et al. (2010) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m110.001917 · Cited by 528
Self-citationMerchant, M. L., Rood, I. M., Deegens, J. K., & Klein, J. B. (2017) · Nature Reviews Nephrology · doi:10.1038/nrneph.2017.148 · Cited by 509
Self-citationZhou, H., Pisitkun, T., Aponte, A. M., Yuen, P. S. T., Hoffert, J. D., Yasuda, H., Hu, X., Chawla, L. S., Shen, R., Knepper, M. A., et al. (2006) · Kidney International · doi:10.1038/sj.ki.5001874 · Cited by 446
Discovery of Urinary Biomarkers
Pisitkun, T., Johnstone, R. M., & Knepper, M. A. (2006) · Molecular & Cellular Proteomics · doi:10.1074/mcp.r600004-mcp200 · Cited by 403
Current issues in measurement and reporting of urinary albumin excretion
Miller, W. G., Bruns, D. E., Hortin, G. L., Sandberg, S., Aakre, K. M., McQueen, M. J., Itoh, Y., Lieske, J. C., Seccombe, D. W., Jones, G., et al. (2009) · Clinical Chemistry · doi:10.1373/clinchem.2008.106567 · Cited by 381
Pieper, R., Gatlin, C. L., McGrath, A. M., Makusky, A. J., Mondal, M., Seonarain, M., Jeffery, E. D., Schatz, C. R., Estock, M. A., Ahmed, N., et al. (2004) · PROTEOMICS · doi:10.1002/pmic.200300661 · Cited by 356
Schaub, S., Wilkins, J. A., Weiler, T., Sangster, K. T., Rush, D. N., & Nickerson, P. W. (2003) · Kidney International · doi:10.1111/j.1523-1755.2004.00352.x · Cited by 324
Feist, P. E., & Hummon, A. B. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16023537 · Cited by 306
Advances in Urinary Proteome Analysis and Biomarker Discovery
Fliser, D., Novák, J., Thongboonkerd, V., Accent]s, A. G. A. A. A., Jankowski, V., Girolami, M., Jankowski, J., & Mischak, H. (2007) · Journal of the American Society of Nephrology · doi:10.1681/asn.2006090956 · Cited by 289
Self-citationReed, T., Perluigi, M., Sultana, R., Pierce, W. M., Klein, J. B., Turner, D. M., Coccia, R., Markesbery, W. R., & Butterfield, D. A. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2007.12.007 · Cited by 257
Self-citationRood, I. M., Deegens, J. K., Merchant, M. L., Tamboer, W. P. M., Wilkey, D. W., Wetzels, J. F. M., & Klein, J. B. (2010) · Kidney International · doi:10.1038/ki.2010.262 · Cited by 259
Self-citationDallas, D. C., Guerrero, A., Parker, E. A., Robinson, R. C., Gan, J., German, J. B., Barile, D., & Lebrilla, C. B. (2014) · PROTEOMICS · doi:10.1002/pmic.201400310 · Cited by 257
ADAM 12 Cleaves Extracellular Matrix Proteins and Correlates with Cancer Status and Stage
Roy, R., Wewer, U. M., Zurakowski, D., Pories, S. E., & Moses, M. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409565200 · Cited by 244
Renal and urinary proteomics: Current applications and challenges
Thongboonkerd, V., & Malasit, P. (2005) · PROTEOMICS · doi:10.1002/pmic.200401012 · Cited by 235
Self-citationExploring the Hidden Human Urinary Proteome via Ligand Library Beads
Castagna, A., Cecconi, D., Sennels, L., Rappsilber, J., Guerrier, L., Fortis, F., Boschetti, E., Lomas, L., & Righetti, P. G. (2005) · Journal of Proteome Research · doi:10.1021/pr050153r · Cited by 237
Protein Equalizer™ Technology : The quest for a “democratic proteome”
Righetti, P. G., Boschetti, E., Lomas, L., & Citterio, A. (2006) · PROTEOMICS · doi:10.1002/pmic.200500904 · Cited by 232
Kemna, E., Tjalsma, H., Podust, V. N., & Swinkels, D. W. (2007) · Clinical Chemistry · doi:10.1373/clinchem.2006.079186 · Cited by 222
Urine protein patterns can serve as diagnostic tools in patients with IgA nephropathy
Haubitz, M., Wittke, S., Weissinger, E. M., Walden, M., Rupprecht, H., Floege, J., Haller, H. G., & Mischak, H. (2005) · Kidney International · doi:10.1111/j.1523-1755.2005.00335.x · Cited by 221
Weissinger, E. M., Wittke, S., Kaiser, T., Haller, H. G., Bartel, S. J., Krebs, R., Golovko, I., Rupprecht, H., Haubitz, M., Hecker, H., et al. (2004) · Kidney International · doi:10.1111/j.1523-1755.2004.00659.x · Cited by 209
Practical Points in Urinary Proteomics
Thongboonkerd, V. (2007) · Journal of Proteome Research · doi:10.1021/pr070328s · Cited by 208
Self-citationCE‐MS analysis of the human urinary proteome for biomarker discovery and disease diagnostics
Coon, J. J., Zürbig, P., Dakna, M., Dominiczak, A. F., Decramer, S., Fliser, D., Frommberger, M., Golovko, I., Good, D. M., Herget‐Rosenthal, S., et al. (2008) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.200800024 · Cited by 208
Opii, W. O., Joshi, G., Head, E., Milgram, N. W., Muggenburg, B. A., Klein, J. B., Pierce, W. M., Cotman, C. W., & Butterfield, D. A. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.09.012 · Cited by 202
Self-citationPerluigi, M., Sultana, R., Cenini, G., Di Domenico, F., Memo, M., Pierce, W. M., Coccia, R., & Butterfield, D. A. (2009) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.200800161 · Cited by 196
Zürbig, P., Renfrow, M. B., Schiffer, E., Novák, J., Walden, M., Wittke, S., Just, I., Pelzing, M., Neusüß, C., Theodorescu, D., et al. (2006) · Electrophoresis · doi:10.1002/elps.200500827 · Cited by 192
Schmidt, H., Pandit, B., Martinsen, V., Cornelissen, G., Conte, P., & Kammann, C. (2015) · Agriculture · doi:10.3390/agriculture5030723 · Cited by 187
Proteomic Analysis of Protein Expression and Oxidative Modification in R6/2 Transgenic Mice
Marzia Perluigi, A., Poon, H. F., Maragos, W. F., Pierce, W. M. J., Klein, J. B., Calabrese, V., Cini, C., Marco, C. M. D., & Butterfield, D. A. (2005) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m500090-mcp200 · Cited by 184
Self-citationProteomic analysis for the assessment of diabetic renal damage in humans
Mischak, H., Kaiser, T., Walden, M., Hillmann, M., Wittke, S., Herrmann, A., Knueppel, S., Haller, H. G., & Fliser, D. (2004) · Clinical Science · doi:10.1042/cs20040103 · Cited by 174
Thongboonkerd, V., Chutipongtanate, S., & Kanlaya, R. (2005) · Journal of Proteome Research · doi:10.1021/pr0502525 · Cited by 173
Self-citationProspects for urinary proteomics: Exosomes as a source of urinary biomarkers (Review Article)
Hoorn, E. J., Pisitkun, T., Zietse, R., Gross, P. A., FROKIAER, J., Wang, N. S., Gonzales, P. A., Star, R. A., & Knepper, M. A. (2005) · Nephrology · doi:10.1111/j.1440-1797.2005.00387.x · Cited by 172
Fiedler, M., Baumann, S., Leichtle, A. B., Oltmann, A., Kase, J., Thiery, J., & Ceglarek, U. (2007) · Clinical Chemistry · doi:10.1373/clinchem.2006.077834 · Cited by 170
Maximizing recovery of water-soluble proteins through acetone precipitation
Crowell, A. M. J., Wall, M. J., & Doucette, A. A. (2013) · Analytica Chimica Acta · doi:10.1016/j.aca.2013.08.005 · Cited by 174
Opii, W. O., Nukala, V. N., Rukhsana Sultana, A., Pandya, J. D., Day, K. M., Merchant, M. L., Klein, J. B., Sullivan, P. G., & Butterfield, D. A. (2007) · Journal of Neurotrauma · doi:10.1089/neu.2006.0229 · Cited by 161
Self-citationMischak, H., Kölch, W., Aivaliotis, M., Bouyssié, D., Court, M., Dihazi, H., Dihazi, G. H., Franke, J., Garin, J., de Peredo, A. G., et al. (2010) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.200900189 · Cited by 156
Self-citationMarzia Perluigi, A., Poon, H. F., Hensley, K., Pierce, W. M. J., Klein, J. B., Calabrese, V., Marco, C. M. D., & Butterfield, D. A. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.12.021 · Cited by 151
Self-citationHuman urine proteome analysis by three separation approaches
Sun, W., Li, F., Wu, S., Wang, X., Zheng, D., Wang, J., & Gao, Y. (2005) · PROTEOMICS · doi:10.1002/pmic.200401334 · Cited by 146
Different techniques for urinary protein analysis of normal and lung cancer patients
Tantipaiboonwong, P., Sinchaikul, S., Sriyam, S., Phutrakul, S., & Chen, S. (2005) · PROTEOMICS · doi:10.1002/pmic.200401143 · Cited by 142
Approaching clinical proteomics: current state and future fields of application in fluid proteomics
Apweiler, R., Aslanidis, C., Deufel, T., Gerstner, A. O. H., Hansen, J., Hochstrasser, D. F., Kellner, R., Kubicek, M., Lottspeich, F., Maser, E., et al. (2009) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2009.167 · Cited by 138
Sharma, K., Lee, S., Han, S., Lee, S., Francos, B. B., McCue, P. A., Wassell, R. P., Shaw, M., & RamachandraRao, S. P. (2005) · PROTEOMICS · doi:10.1002/pmic.200401288 · Cited by 130
Proteomics: a novel tool to unravel the patho-physiology of uraemia
Weissinger, E. M., Kaiser, T., Meert, N., Smet, R. D., Walden, M., Mischak, H., Vanholder, R. C., & for the European Uremic Toxin Work Group (2004) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfh509 · Cited by 123
Concanavalin A-captured Glycoproteins in Healthy Human Urine
Wang, L., Li, F., Sun, W., Wu, S., Wang, X., Zhang, L., Zheng, D., Wang, J., & Gao, Y. (2005) · Molecular & Cellular Proteomics · doi:10.1074/mcp.d500013-mcp200 · Cited by 123
Human urinary peptide database for multiple disease biomarker discovery
Siwy, J., Mullen, W., Golovko, I., Franke, J., & Zürbig, P. (2011) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201000155 · Cited by 118
Rehman, I., Azzouzi, A.-R., Catto, J. W. F., Allen, S. P., Cross, S. S., Feeley, K. M., Meuth, M., & Hamdy, F. C. (2004) · Urology · doi:10.1016/j.urology.2004.06.063 · Cited by 114
Beretov, J., Wasinger, V. C., Millar, E. K. A., Schwartz, P. E., Graham, P., & Li, Y. (2015) · PLoS ONE · doi:10.1371/journal.pone.0141876 · Cited by 110
Urinary Biomarkers for Acute Kidney Injury in Dogs
Loor, J. D., Daminet, S., Smets, P. M. Y., Maddens, B., & Meyer, E. (2013) · Journal of Veterinary Internal Medicine · doi:10.1111/jvim.12155 · Cited by 109
Rapid and Quantitative Protein Precipitation for Proteome Analysis by Mass Spectrometry
Nickerson, J. L., & Doucette, A. A. (2020) · Journal of Proteome Research · doi:10.1021/acs.jproteome.9b00867 · Cited by 108
Comparison of sodium dodecyl sulfate depletion techniques for proteome analysis by mass spectrometry
Kachuk, C., Stephen, K., & Doucette, A. A. (2015) · Journal of Chromatography A · doi:10.1016/j.chroma.2015.09.042 · Cited by 106
Owen, J. B., Domenico, F. D., Rukhsana Sultana, A., Marzia Perluigi, A., Cini, C., Pierce, W. M. J., & Butterfield, D. A. (2008) · Journal of Proteome Research · doi:10.1021/pr800667a · Cited by 102
Capillary electrophoresis coupled to mass spectrometry for clinical diagnostic purposes
Fliser, D., Wittke, S., & Mischak, H. (2005) · Electrophoresis · doi:10.1002/elps.200500187 · Cited by 99
Ren, Y., Wang, H., Liu, J., Zhang, Z., McLuckey, M. N., & Ouyang, Z. (2013) · Chromatographia · doi:10.1007/s10337-013-2458-y · Cited by 97
Schiffer, E., Mischak, H., & Novák, J. (2006) · PROTEOMICS · doi:10.1002/pmic.200600230 · Cited by 98
Characterisation of Human Tear Proteins Using High-resolution Mass Spectrometry
Zhou, L., Beuerman, R. W., Foo, Y. H., Liu, S., Ang, L. P., & Tan, D. T. H. (2006) · Annals of the Academy of Medicine Singapore · doi:10.47102/annals-acadmedsg.v35n6p400 · Cited by 96
Proteomics in 2002: A Year of Technical Development and Wide-Ranging Applications
Figeys, D. (2003) · Analytical Chemistry · doi:10.1021/ac030142m · Cited by 95
Urinary exosomes and proteomics
Moon, P., You, S., Lee, J., Hwang, D., & Baek, M. (2011) · Mass Spectrometry Reviews · doi:10.1002/mas.20319 · Cited by 94
Domenico, F. D., Rukhsana Sultana, A., Barone, E., Marzia Perluigi, A., Cini, C., Mancuso, C., Cai, J., Pierce, W. M. J., & Butterfield, D. A. (2011) · Journal of Proteomics · doi:10.1016/j.jprot.2011.03.033 · Cited by 91
Optimizing a Proteomics Platform for Urine Biomarker Discovery
Afkarian, M., Bhasin, M., Dillon, S. T., Guerrero, M. C., Nelson, R. G., Knowler, W. C., Thadhani, R., & Libermann, T. A. (2010) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m110.000992 · Cited by 91
Proteomics in Nephrology: Current Status and Future Directions
Thongboonkerd, V. (2004) · American Journal of Nephrology · doi:10.1159/000079148 · Cited by 88
Self-citationSimple Urinary Sample Preparation for Proteomic Analysis
Khan, A., & Packer, N. H. (2006) · Journal of Proteome Research · doi:10.1021/pr060305y · Cited by 88
Cutillas, P. R., Norden, A. G. W., Cramer, R., Burlingame, A. L., & Unwin, R. J. (2003) · Clinical Science · doi:10.1042/cs20020342 · Cited by 87
González-Buitrago, J. M., Ferreira, L., & Lorenzo, I. (2006) · Clinica Chimica Acta · doi:10.1016/j.cca.2006.07.027 · Cited by 85
Andersen, S., Mischak, H., Zürbig, P., Parving, H., & Rossing, P. R. (2010) · BMC Nephrology · doi:10.1186/1471-2369-11-29 · Cited by 84
Li, Q., Fan, K., Li, R.-X., Dai, J., Wu, C., Zhao, S.-L., Wu, J., Shieh, C., & Zeng, R. (2010) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.4441 · Cited by 84
Urinary proteomics: towards biomarker discovery, diagnostics and prognostics
Thongboonkerd, V. (2008) · Molecular BioSystems · doi:10.1039/b802534g · Cited by 83
Self-citationEstablishment of a 2‐D human urinary proteomic map in IgA nephropathy
Park, M., Wang, E., Jin, D. C., Cha, J., Lee, K.-H., Yang, C. W., Kang, C., & Choi, Y. J. (2005) · PROTEOMICS · doi:10.1002/pmic.200500023 · Cited by 83
Urine protein profile of IgA nephropathy patients may predict the response to ACE‐inhibitor therapy
Rocchetti, M. T., Centra, M., Papale, M., Bortone, G., Palermo, C., Centonze, D., Ranieri, E., Paolo, S. D., & Gesualdo, L. (2007) · PROTEOMICS · doi:10.1002/pmic.200700492 · Cited by 80
Koh, J., Chen, S., Zhu, N., Yu, F., Soltis, P. S., & Soltis, P. S. (2012) · New Phytologist · doi:10.1111/j.1469-8137.2012.04251.x · Cited by 79
Li, M., Zhao, M., & Gao, Y. (2014) · Science China Life Sciences · doi:10.1007/s11427-014-4661-y · Cited by 74
Optimizing Sample Handling for Urinary Proteomics
Lee, R. S., Monigatti, F., Briscoe, A. C., Waldon, Z., Freeman, M. R., & Steen, H. (2008) · Journal of Proteome Research · doi:10.1021/pr800301h · Cited by 74
Proteomics of Urinary Vesicles Links Plakins and Complement to Polycystic Kidney Disease
Salih, M., Demmers, J., Bezstarosti, K., Leonhard, W. N., Losekoot, M., van Kooten, C., Gansevoort, R. T., Peters, D. J. M., Zietse, R., & Hoorn, E. J. (2016) · Journal of the American Society of Nephrology · doi:10.1681/asn.2015090994 · Cited by 74
Triplett, J. C., Tramutola, A., Swomley, A. M., Kirk, J. M., Grimes, K. M., Hardell, K. N. L., Orr, M. E., Rodriguez, K. A., Cai, J., Klein, J. B., et al. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.08.002 · Cited by 73
Self-citationMAp19, the alternative splice product of the MASP2 gene
Degn, S. E., Thiel, S., Nielsen, O., Hansen, A. G., Steffensen, R., & Jensenius, J. C. (2011) · Journal of Immunological Methods · doi:10.1016/j.jim.2011.08.006 · Cited by 71
Ramadasan-Nair, R., Gayathri, N., Mishra, S., Sunitha, B., Mythri, R. B., Nalini, A., Subbannayya, Y., Harsha, H. C., Kolthur‐Seetharam, U., & Bharath, M. M. S. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.493270 · Cited by 68
Recent progress in urinary proteomics
Thongboonkerd, V. (2007) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.200700035 · Cited by 66
Self-citationImpedimetric method for measuring ultra-low E. coli concentrations in human urine
Settu, K., Chen, C.-J., Liu, J.-T., Chen, C., & Tsai, J. (2014) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2014.11.027 · Cited by 66
2D-electrophoresis and the urine proteome map: Where do we stand?
Candiano, G., Santucci, L., Petretto, A., Bruschi, M., Dimuccio, V., Urbani, A., Bagnasco, S. M., & Ghiggeri, G. M. (2009) · Journal of Proteomics · doi:10.1016/j.jprot.2009.12.003 · Cited by 64
Doucette, A. A., Vieira, D. B., Orton, D. J., & Wall, M. J. (2014) · Journal of Proteome Research · doi:10.1021/pr500864a · Cited by 63
Thongboonkerd, V., & Saetun, P. (2007) · Journal of Proteome Research · doi:10.1021/pr070311+ · Cited by 63
Self-citationToward a standardized urine proteome analysis methodology
Court, M., Selevsek, N., Matondo, M., Allory, Y., Garin, J., Masselon, C., & Domon, B. (2011) · PROTEOMICS · doi:10.1002/pmic.201000566 · Cited by 62
Non-invasive markers of ureteropelvic junction obstruction
Decramer, S., Bascands, J., & Schanstra, J. P. (2007) · World Journal of Urology · doi:10.1007/s00345-007-0201-8 · Cited by 62
Tilton, R. G., Haidacher, S. J., LeJeune, W. S., Zhang, X., Zhao, Y., Kurosky, A., Brasier, A. R., & Denner, L. A. (2007) · PROTEOMICS · doi:10.1002/pmic.200700017 · Cited by 62
Bastos, P. A. D., Trindade, F., da Costa, J. P., Ferreira, R. M., & Vitorino, R. M. P. (2017) · Medicinal Research Reviews · doi:10.1002/med.21435 · Cited by 63
Boonla, C., Tosukhowong, P., Spittau, B., Schlösser, A., Pimratana, C., & KRIEGLSTEIN, K. G. (2013) · Clinica Chimica Acta · doi:10.1016/j.cca.2013.11.036 · Cited by 61
Differential proteomic analysis of proteins induced by glucocorticoids in cultured murine podocytes
Ransom, R. F., Vega-Warner, V., Smoyer, W. E., & Klein, J. B. (2005) · Kidney International · doi:10.1111/j.1523-1755.2005.00205.x · Cited by 61
Self-citationCharacterization of the human urine proteome by preparative electrophoresis in combination with 2‐DE
Zerefos, P. G., Vougas, K. N., Dimitraki, P., Κοσσίδα, Σ., Petrolekas, A., STRAVODIMOS, K. G., Giannopoulos, A., Fountoulakis, M., & Vlahou, A. (2006) · PROTEOMICS · doi:10.1002/pmic.200500671 · Cited by 61
Triplett, J. C., Zhang, Z., Sultana, R., Cai, J., Klein, J. B., Büeler, H., & Butterfield, D. A. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13039 · Cited by 58
Self-citationProfiling of urinary proteins in Karan Fries cows reveals more than 1550 proteins
Bathla, S., Rawat, P., Baithalu, R. K., Yadav, M. L., Naru, J., Tiwari, A. K., Kumar, S., Balhara, A. K., Singh, S., Chaudhary, S., et al. (2015) · Journal of Proteomics · doi:10.1016/j.jprot.2015.05.026 · Cited by 58
Biomarkers and Updates on Pediatrics Lupus Nephritis
BENNETT, M. R., & Brunner, H. I. (2013) · Rheumatic Disease Clinics of North America · doi:10.1016/j.rdc.2013.05.001 · Cited by 57
Protein Profiling of Urine from Dogs with Renal Disease Using ProteinChip Analysis
Forterre, S., Raila, J., & Schweigert�, F. J. (2004) · Journal of Veterinary Diagnostic Investigation · doi:10.1177/104063870401600403 · Cited by 56
Proteome profile of human urine with two‐dimensional liquid phase fractionation
Soldi, M., Sarto, C., Valsecchi, C., Magni, F., Proserpio, V., Ticozzi, D., & Mocarelli, P. (2005) · PROTEOMICS · doi:10.1002/pmic.200401269 · Cited by 56
Regulation by macromolecules of calcium oxalate crystal aggregation in stone formers
Wesson, J. A., Ganne, V., Beshensky, A. M., & Kleinman, J. G. (2005) · Urological Research · doi:10.1007/s00240-004-0455-1 · Cited by 56
Two dimensional electrophoretic analysis of human tears: Collection method in dry eye syndrome
Saijyothi, A. V., Angayarkanni, N., Syama, C., Utpal, T., Agarwal, S., Srinivasan, B., Iyer, G. K., Pillai, V. S., Maruthamuthu, T., Rajappa, S. M., et al. (2010) · Electrophoresis · doi:10.1002/elps.201000271 · Cited by 55
From hundreds to thousands: Widening the normal human Urinome
Santucci, L., Candiano, G., Petretto, A., Bruschi, M., Lavarello, C., Inglese, E., Righetti, P. G., & Ghiggeri, G. M. (2014) · Data in Brief · doi:10.1016/j.dib.2014.08.006 · Cited by 55
Proteomic analysis of early urinary biomarkers of renal changes in type 2 diabetic patients
Bellei, E., Rossi, E. G., Lucchi, L., Uggeri, S., Albertazzi, A., Tomasi, A., & Iannone, A. (2008) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.200780109 · Cited by 54
Krishna, J., Shah, Z. A., Merchant, M. L., Klein, J. B., & Gozal, D. (2006) · Sleep Medicine · doi:10.1016/j.sleep.2005.09.010 · Cited by 53
Self-citationRecovery of urinary nanovesicles from ultracentrifugation supernatants
Musante, L., Saraswat, M., Ravidà, A., Byrne, B. J., & Holthöfer, H. (2012) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfs564 · Cited by 53
Bruschi, M., Granata, S., Santucci, L., Candiano, G., Fabris, A., Antonucci, N., Petretto, A., Bartolucci, M., Zotto, G. D., Antonini, F., et al. (2019) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.12191018 · Cited by 52
Urinary fractalkine is a marker of acute rejection
Peng, W., Chen, J., Jiang, Y., Wu, J., Shou, Z., He, Q., Wang, Y., Chen, Y., & Wang, H. (2008) · Kidney International · doi:10.1038/ki.2008.459 · Cited by 51
Proteomic analysis of renal diseases: unraveling the pathophysiology and biomarker discovery
Thongboonkerd, V. (2005) · Expert Review of Proteomics · doi:10.1586/14789450.2.3.349 · Cited by 51
Self-citationSodium loading changes urinary protein excretion: a proteomic analysis
Thongboonkerd, V., Klein, J. B., Pierce, W. M. J., Jevans, A. W., & Arthur, J. M. (2003) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00140.2002 · Cited by 50
Self-citation
Metadata
- Authors
- Thongboonkerd, V., Mcleish, K. R., Arthur, J. M., & Klein, J. B.
- Affiliations
- University of Louisville (US)
- Venue
- Kidney International
- Publisher
- Elsevier BV
- Published
- 2002-10
- Volume
- 62
- Issue
- 4
- Pages
- 1461-1469
- ISSN
- 0085-2538 (ISSN-L)
- OpenAlex
- W2047018178
- Cited by
- 359
- References
- 17
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 6 · 2023: 11 · 2022: 4 · 2021: 5 · 2020: 10 · 2019: 8 · 2018: 9 · 2017: 10 · 2016: 11 · 2015: 22 · 2014: 22 · 2013: 22 · 2012: 13
- FWCI
- 8.84
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Kidney International (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Louisville
- National Heart, Lung, and Blood Institute (R01-HL-66358-01, R01HL066358)
- Topics
- Physical Sciences › Chemistry › Spectroscopy › Advanced Proteomics Techniques and Applications
- Physical Sciences › Chemistry › Spectroscopy › Mass Spectrometry Techniques and Applications
- Health Sciences › Medicine › Nephrology › Renal Diseases and Glomerulopathies
- Keywords
- urinary protein, acetone precipitation, ultracentrifugation, protein fractionation, glycosylation, renal biomarkers, renal physiology
- MeSH terms
- Acetone, Humans, Peptide Mapping, Chemical Precipitation, Proteins, Serine Endopeptidases, Solvents, Staining and Labeling, Ultracentrifugation, Urine, Electrophoresis, Gel, Two-Dimensional, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Computational Biology, Proteomics, Tryptases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review