The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
A Report Card to Grade Helicobacter pylori Therapy
Abstract
Helicobacter pylori causes a serious bacterial infectious disease, and the expectations of therapy should reflect this fact. Increasing antibiotic resistance, especially to clarithromycin, has significantly undermined the effectiveness of legacy triple therapy consisting of a proton pump inhibitor, clarithromycin, and amoxicillin. Current cure rates are consistently below 80% intention‐to‐treat, the accepted threshold separating acceptable from unacceptable treatment results. Grading clinical studies into effectiveness categories using prespecified criteria would allow clinicians to objectively identify and compare regimens. We offer a therapy report card similar to that used to grade the performance of school children. The intention‐to‐treat cure rate categories are: F or unacceptable ( 80%), D or poor (81–84%), C or fair (85–89%), B or good (90–95%), and A or excellent (95–100%). The category of “excellent” is based on the cure rates expected with other prevalent bacterial infectious diseases. We propose that only therapies that score “excellent” (grade = A) should be prescribed. Regimens scoring as B or “good” can be used if “excellent” results are not obtainable. In most regions legacy triple therapy should be abandoned as unacceptable. Quadruple therapy and sequential therapy are reasonable alternatives for initial therapy.
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Malfertheiner, P., Mégraud, F., OʼMorain, C., Bell, D., Porro, B. G., Deltenre, M., Forman, D., Gasbarrini, G., Jaup, B., Misiewicz, J. J., et al. (1997) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-199701000-00002 · Cited by 980
Vaira, D., Zullo, A., Vakil, N., Gatta, L., Ricci, C., Perna, F., Hassan, C., Bernabucci, V., Tampieri, A., & Morini, S. (2007) · Annals of Internal Medicine · doi:10.7326/0003-4819-146-8-200704170-00006 · Cited by 266
Sequential Therapy versus Standard Triple-Drug Therapy for Helicobacter pylori Eradication
(2007) · Annals of Internal Medicine · doi:10.7326/0003-4819-146-8-200704170-00002 · Cited by 262
High eradication rates of Helicobacter pylori with a new sequential treatment
Zullo, A., Vaira, D., Vakil, N., Hassan, C., Gatta, L., Ricci, C., De Francesco, V., Menegatti, M., Tampieri, A., Perna, F., et al. (2003) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2003.01461.x · Cited by 225
Seven‐day therapy for Helicobacter pylori in the United States
Vakil, N. B., Lanza, F., Schwartz, H., & Barth, J. (2004) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2004.02029.x · Cited by 175
Treatment of Helicobacter pylori
Egan, B. J., Katicic, M., O’Connor, H. J., & O'Morain, C. A. (2007) · Helicobacter · doi:10.1111/j.1523-5378.2007.00538.x · Cited by 158
Treiber, G., Wittig, J., Ammon, S., Walker, S., van Doorn, L., & Klotz, U. E. (2002) · Archives of Internal Medicine · doi:10.1001/archinte.162.2.153 · Cited by 115
Kim, B. G., Lee, D. H., Ye, B. D., Lee, K. H., Kim, B. W., Kim, S. G., Kim, S. W., Kim, S. K., Kim, J. J., Kim, H. Y., et al. (2007) · Helicobacter · doi:10.1111/j.1523-5378.2007.00468.x · Cited by 111
Take, S., Mizuno, M., Ishiki, K., Nagahara, Y., Yoshida, T., Inaba, T., Yamamoto, K., Okada, H., Yokota, K., Oguma, K., et al. (2003) · The American Journal of Gastroenterology · doi:10.1016/s0002-9270(03)00713-5 · Cited by 76
Cited by
Second Asia–Pacific Consensus Guidelines for Helicobacter pylori infection
Fock, K. M., Katelaris, P., Sugano, K., Ang, T. L., Hunt, R., Talley, N. J., Lam, S. K., Xiao, S., Tan, H. J., Wu, C., et al. (2009) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2009.05982.x · Cited by 554
Zhang, J., Zhao, X., Jiang, Y., Zhao, W., Guo, T., Cao, Y., Teng, J., Hao, X., Zhao, J., & Yang, Z. (2017) · Journal of Dairy Science · doi:10.3168/jds.2016-12480 · Cited by 141
Metadata
- Authors
- Graham, D. Y., Lu, H., & Yamaoka, Y.
- Venue
- Helicobacter
- Publisher
- Wiley
- Published
- 2007-07-30
- Volume
- 12
- Issue
- 4
- Pages
- 275-278
- ISSN
- 1083-4389 (ISSN-L)
- 1523-5378
- OpenAlex
- W2017178544
- Cited by
- 393
- References
- 13
- FWCI
- 10.40
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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