Effect of Topical Vitamin C on Postoperative Carbon Dioxide Laser Resurfacing Erythema
Abstract
Background Postoperative erythema of several months duration is a universal and problematic side effect of cutaneous carbon dioxide (CO2) laser resurfacing. Objective This study was conducted in order to determine the effectiveness of two formulations of topical ascorbic acid in reducing the degree and duration of post-CO2 laser resurfacing erythema. Results The application of topical L-ascorbic acid in an aqueous formulation resulted in a significant decrease in post-CO2 laser resurfacing erythema by the eighth postoperative week when compared with laser-irradiated skin that had not received topical vitamin C. The application of topical ascorbic acid in a cream formulation did not result in a significant reduction in post-CO2 laser resurfacing erythema. Conclusion Topical L-ascorbic acid, when used in an appropriate vehicle and when initiated at an appropriate postoperative period, may decrease the degree and duration of erythema after cutaneous CO2 laser resurfacing. It is presumed that the anti-inflammatory effect of vitamin C is responsible for the clinical changes observed in this study.
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Antioxidants have demonstrated effectiveness in managing inflammation and mitigating postoperative oxidative stress by neutralizing oxygen radicals.
“Antioxidants have demonstrated effectiveness in managing inflammation and mitigating postoperative oxidative stress by neutralizing oxygen radicals [11, 12].”
Cites
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Molecular Mechanisms of Dermal Aging and Antiaging Approaches
Shin, J.-W., Kwon, S.-H., Choi, J.-Y., Na, J.-I., Huh, C.-H., Choi, H.-R., & Park, K.-C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092126 · Cited by 875 · see citing works
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Self-citationQin, X., Zhai, J., Zhou, C., Wang, Y., Chen, M., Zhu, L., Shi, Q., Chen, W., Zhang, L., Luo, X., et al. (2025) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.70251 · Cited by 3 · see citing works
- Authors
- ALSTER, T. S., & WEST, T. B.
- Affiliations
- Washington Institute of Dermatologic Laser Surgery (US)
- ORCID
- ALSTER, TINA S.
- Venue
- Dermatologic Surgery
- Published
- 1998-03
- Volume
- 24
- Issue
- 3
- Pages
- 331-334
- ISSN
- 1076-0512 (ISSN-L)
- OpenAlex
- W2056379293
- Cited by
- 93
- References
- 1
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 3 · 2023: 3 · 2022: 4 · 2021: 4 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 4 · 2014: 2 · 2013: 5 · 2012: 3
- FWCI
- 10.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Dermatologic Surgery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
- Health Sciences › Medicine › Dermatology › Facial Rejuvenation and Surgery Techniques
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Keywords
- topical vitamin C, vitamin C, carbon dioxide laser resurfacing, postoperative erythema, anti-inflammatory activity, topical cream formulation, laser-induced skin damage
- MeSH terms
- Administration, Topical, Adult, Aged, Ascorbic Acid, Erythema, Female, Humans, Male, Middle Aged, Rhytidoplasty, Laser Therapy, Dermatologic Surgical Procedures
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