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Cited by 83Wound Healing and TreatmentsDermatologic Treatments and ResearchFibroblast Growth Factor Research

The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.

Basic fibroblast growth factor (bFGF) alleviates the scar of the rabbit ear model in wound healing

Xie, Ju Lin, Bian, Hui Ning, Qi, Shao Hai, Chen, Hua De, Li, Hou Dong, Xu, Ying Bin, Li, Tian Zeng, Liu, Xu Sheng, Liang, Hui Z., Xin, Bang Rong, Huan, Yong·2008·Wound Repair and Regeneration
DOI 10.1111/j.1524-475x.2008.00405.x
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Abstract

Studies suggest a possible antiscarring effect of basic fibroblast growth factor (bFGF) during wound healing. However, little is known about the precise pathological mechanisms of bFGF. In particular, there is only limited information available about the mechanism of exogenous administration of bFGF to scar formation. To investigate the effect of bFGF on the hypertrophic scar in the rabbit ear model and to clarify the mechanisms of bFGF on treatment for scar in wound healing, the rabbit ear model of wound healing was created and treated topically with bFGF once daily for 3 months; then we examined the changes of macroscopic and histopathological characteristics of scars and the expression of collagen and collagenase-1 (matrix metalloproteinase-1). The results of macroscopic and histologic characteristics revealed a significant difference between scars treated with bFGF and control scars. The expression of collagen in the scars treated with bFGF was decreased, as compared with the scars treated with saline. Further study revealed that bFGF could remarkably enhance expression of matrix metalloproteinase-1. bFGF could improve the quality of wound healing and remarkably alleviate the scar in the rabbit ear model in wound healing, which suggests that bFGF exerted a net negative effecton scar formation in wound healing. The evidence should contribute to a better understanding of the biological activities of bFGF during hypertrophic scar formation.

Overview

Integrity signals

Registry

Crossref · 10.1111/j.1524-475x.2008.00405.x

Cites

13 of 13 references verified0 citation errors · 0 not checkable

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Citations

Cites

Show all 13 references

Research works printed but not linked: 5

  1. Kondo T, 1996, The dynamics of inflammatory cytokines in the healing process of mouse skin wound, a preliminary study for possible wound age determination, 108, 231
  2. Kloeters O, 2007, Hypertrophic scar model in the rabbit ear, a reproducible model for studying scar tissue behavior with new observations on silicone get sheeting for scar reduction, 15, 40
  3. 2003, Stamenkovic. Extracellular matrix remodeling, the role of matrix metalloproteinases, 4, 448
  4. Birkedal‐Hanson H, 1994, Matrix metalloproteinase, a review, 44, 302
  5. Reynolds JJ., 1996, Collagenases and tissue inhibitors of metalloproteinase, a functional balance in tissue degradation, 2, 70

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Metadata

Authors
Xie, J. L., Bian, H. N., Qi, S. H., Chen, H. D., Li, H. D., Xu, Y. B., Li, T. Z., Liu, X. S., Liang, H. Z., Xin, B. R., & Huan, Y.
Affiliations
  • Sun Yat-sen University (CN)
  • Guangdong Provincial People's Hospital (CN)
ORCID
Xu, Ying Bin
Venue
Wound Repair and Regeneration
Publisher
Wiley
Published
2008-07
Volume
16
Issue
4
Pages
576-581
ISSN
  • 1067-1927 (ISSN-L)
  • 1524-475X
DOI
10.1111/j.1524-475x.2008.00405.x
OpenAlex
W1967382410
Cited by
83
References
13
Citations by year
2026: 1 · 2025: 2 · 2024: 4 · 2023: 2 · 2022: 6 · 2021: 7 · 2020: 3 · 2019: 2 · 2018: 8 · 2017: 9 · 2016: 6 · 2015: 6 · 2014: 7 · 2013: 5 · 2012: 3
FWCI
4.27
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 8 d)
Locations
  • Wound Repair and Regeneration (publishedVersion)
  • PubMed (publishedVersion)
Funders
Sun Yat-sen University
Topics
  • Health Sciences › Medicine › Surgery › Wound Healing and Treatments
  • Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
Keywords
basic fibroblast growth factor, hypertrophic scars, wound healing, rabbit ear model, collagen expression, MMP-1, topical growth factor therapy, scar formation
MeSH terms
Animals, Ear, External, Female, Rabbits, Wound Healing, Blotting, Western, Fibroblast Growth Factor 2, Cicatrix, Hypertrophic, Matrix Metalloproteinase 1

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Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.