The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Basic fibroblast growth factor (bFGF) alleviates the scar of the rabbit ear model in wound healing
Abstract
Studies suggest a possible antiscarring effect of basic fibroblast growth factor (bFGF) during wound healing. However, little is known about the precise pathological mechanisms of bFGF. In particular, there is only limited information available about the mechanism of exogenous administration of bFGF to scar formation. To investigate the effect of bFGF on the hypertrophic scar in the rabbit ear model and to clarify the mechanisms of bFGF on treatment for scar in wound healing, the rabbit ear model of wound healing was created and treated topically with bFGF once daily for 3 months; then we examined the changes of macroscopic and histopathological characteristics of scars and the expression of collagen and collagenase-1 (matrix metalloproteinase-1). The results of macroscopic and histologic characteristics revealed a significant difference between scars treated with bFGF and control scars. The expression of collagen in the scars treated with bFGF was decreased, as compared with the scars treated with saline. Further study revealed that bFGF could remarkably enhance expression of matrix metalloproteinase-1. bFGF could improve the quality of wound healing and remarkably alleviate the scar in the rabbit ear model in wound healing, which suggests that bFGF exerted a net negative effecton scar formation in wound healing. The evidence should contribute to a better understanding of the biological activities of bFGF during hypertrophic scar formation.
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“this phenomenon may be caused by the alternative and regulating effects of bFGF [32], which in this study been brought up by hypoxia.”
From Conditioned Medium from Hypoxic Bone Marrow-Derived Mesenchymal Stem Cells Enhances Wound Healing in Mice (2014) · cites this paper as [32]
Citations
Cites
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Cited by
Chen, L., Xu, Y., Zhao, J., Zhang, Z., Yang, R., Xie, J., Liu, X., & Qi, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0096161 · Cited by 251
Self-citationThe molecular basis of hypertrophic scars
Zhu, Z., Ding, J., & Tredget, E. E. (2016) · Burns & Trauma · doi:10.1186/s41038-015-0026-4 · Cited by 156
Metadata
- Authors
- Xie, J. L., Bian, H. N., Qi, S. H., Chen, H. D., Li, H. D., Xu, Y. B., Li, T. Z., Liu, X. S., Liang, H. Z., Xin, B. R., & Huan, Y.
- Affiliations
- Sun Yat-sen University (CN)
- Guangdong Provincial People's Hospital (CN)
- ORCID
- Xu, Ying Bin
- Venue
- Wound Repair and Regeneration
- Publisher
- Wiley
- Published
- 2008-07
- Volume
- 16
- Issue
- 4
- Pages
- 576-581
- ISSN
- 1067-1927 (ISSN-L)
- 1524-475X
- OpenAlex
- W1967382410
- Cited by
- 83
- References
- 13
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 4 · 2023: 2 · 2022: 6 · 2021: 7 · 2020: 3 · 2019: 2 · 2018: 8 · 2017: 9 · 2016: 6 · 2015: 6 · 2014: 7 · 2013: 5 · 2012: 3
- FWCI
- 4.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Wound Repair and Regeneration (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Sun Yat-sen University
- Topics
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
- Keywords
- basic fibroblast growth factor, hypertrophic scars, wound healing, rabbit ear model, collagen expression, MMP-1, topical growth factor therapy, scar formation
- MeSH terms
- Animals, Ear, External, Female, Rabbits, Wound Healing, Blotting, Western, Fibroblast Growth Factor 2, Cicatrix, Hypertrophic, Matrix Metalloproteinase 1
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
