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Electrically Conductive Biodegradable Polymer Composite for Nerve Regeneration: Electricity‐Stimulated Neurite Outgrowth and Axon Regeneration
Abstract
Abstract: Normal and electrically stimulated PC12 cell cultures and the implantation of nerve guidance channels were performed to evaluate newly developed electrically conductive biodegradable polymer composites. Polypyrrole (PPy) doped by butane sulfonic acid showed a significantly higher number of viable cells compared with PPy doped by polystyrenesulfonate after a 6‐day culture. The PC12 cells were left to proliferate for 6 days, and the PPy‐coated membranes, showing less initial cell adherence, recorded the same proliferation rate as did the noncoated membranes. Direct current electricity at various intensities was applied to the PC12 cell‐cultured conductive membranes. After 7 days, the greatest number of neurites appeared on the membranes with a current intensity approximating 1.7–8.4 μA/cm. Nerve guidance channels made of conductive biodegradable composite were implanted into rats to replace 8 mm of sciatic nerve. The implants were harvested after 2 months and analyzed with immunohistochemistry and transmission electron microscopy. The regenerated nerve tissue displayed myelinated axons and Schwann cells that were similar to those in the native nerve. Electrical stimulation applied through the electrically conductive biodegradable polymers therefore enhanced neurite outgrowth in a current‐dependent fashion. The conductive polymers also supported sciatic nerve regeneration in rats.
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Citations
Cited by
Conducting Polymers for Tissue Engineering
Guo, B., & Ma, P. X. (2018) · Biomacromolecules · doi:10.1021/acs.biomac.8b00276 · Cited by 835
Polypyrrole-coated electrospun PLGA nanofibers for neural tissue applications
Lee, J. Y., Bashur, C. A., Goldstein, A. S., & Schmidt, C. E. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.04.042 · Cited by 735
Ghasemi-Mobarakeh, L., Prabhakaran, M. P., Morshed, M., Nasr-Esfahani, M. H., Baharvand, H., Kiani, S., Al-Deyab, S. S., & Ramakrishna, S. (2011) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.383 · Cited by 698
Nanomaterials for Neural Interfaces
Kotov, N. A., Winter, J. O., Clements, I. P., Jan, E., Timko, B. P., Campidelli, S., Pathak, S., Mazzatenta, A., Lieber, C. M., Prato, M., et al. (2009) · Advanced Materials · doi:10.1002/adma.200801984 · Cited by 504
Current and Novel Polymeric Biomaterials for Neural Tissue Engineering
Boni, R., Ali, A., Shavandi, A., & Clarkson, A. N. (2018) · Journal of Biomedical Science · doi:10.1186/s12929-018-0491-8 · Cited by 439
Metadata
- Authors
- Zhang, Z., Rouabhia, M., Wang, Z., Roberge, C., Shi, G., Roche, P., Li, J., & Dao, L. H.
- Venue
- Artificial Organs
- Publisher
- Wiley
- Published
- 2006-12-21
- Volume
- 31
- Issue
- 1
- Pages
- 13-22
- ISSN
- 0160-564X (ISSN-L)
- 1525-1594
- OpenAlex
- W2022799308
- Cited by
- 231
- References
- 0
- FWCI
- 3.35
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Electrically Conductive Biodegradable Polymer Composite for Nerve Regeneration: Electricity‐Stimulated Neurite Outgrowth and Axon Regeneration. https://app.cochat.ai/papers/10.1111/j.1525-1594.2007.00335.x
- The paper
- Zhang, Z., Rouabhia, M., Wang, Z., Roberge, C., Shi, G., Roche, P., Li, J., & Dao, L. H. (2007). Electrically Conductive Biodegradable Polymer Composite for Nerve Regeneration: Electricity‐Stimulated Neurite Outgrowth and Axon Regeneration. Artificial Organs. https://doi.org/10.1111/j.1525-1594.2007.00335.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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