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Nanomaterials for Neural Interfaces

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Kotov, Nicholas A., Winter, Jessica O., Clements, Isaac P., Jan, Edward, Timko, Brian P., Campidelli, Stéphane, Pathak, Smita, Mazzatenta, Andrea +7 more·2009·Advanced Materials
DOI 10.1002/adma.200801984
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Abstract

This review focuses on the application of nanomaterials for neural interfacing. The junction between nanotechnology and neural tissues can be particularly worthy of scientific attention for several reasons: (i) Neural cells are electroactive, and the electronic properties of nanostructures can be tailored to match the charge transport requirements of electrical cellular interfacing. (ii) The unique mechanical and chemical properties of nanomaterials are critical for integration with neural tissue as long‐term implants. (iii) Solutions to many critical problems in neural biology/medicine are limited by the availability of specialized materials. (iv) Neuronal stimulation is needed for a variety of common and severe health problems. This confluence of need, accumulated expertise, and potential impact on the well‐being of people suggests the potential of nanomaterials to revolutionize the field of neural interfacing. In this review, we begin with foundational topics, such as the current status of neural electrode (NE) technology, the key challenges facing the practical utilization of NEs, and the potential advantages of nanostructures as components of chronic implants. After that the detailed account of toxicology and biocompatibility of nanomaterials in respect to neural tissues is given. Next, we cover a variety of specific applications of nanoengineered devices, including drug delivery, imaging, topographic patterning, electrode design, nanoscale transistors for high‐resolution neural interfacing, and photoactivated interfaces. We also critically evaluate the specific properties of particular nanomaterials—including nanoparticles, nanowires, and carbon nanotubes—that can be taken advantage of in neuroprosthetic devices. The most promising future areas of research and practical device engineering are discussed as a conclusion to the review.

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Authors
Kotov, N. A., Winter, J. O., Clements, I. P., Jan, E., Timko, B. P., Campidelli, S., Pathak, S., Mazzatenta, A., Lieber, C. M., Prato, M., Bellamkonda, R. V., Silva, G. A., Kam, N. W. S., Patolsky, F., & Ballerini, L.
Affiliations
  • Georgia Institute of Technology (US)
  • University of Michigan (US)
  • Harvard University (US)
  • University of Trieste (IT)
  • University of California San Diego (US)
Corresponding author
  • Kotov, Nicholas A.
  • Winter, Jessica O.
  • Lieber, Charles M.
  • Prato, Maurizio
  • Bellamkonda, Ravi V.
  • Silva, Gabriel A.
ORCID
Venue
Advanced Materials
Publisher
Wiley
Published
2009-10-16
Volume
21
Issue
40
Pages
3970-4004
ISSN
  • 0935-9648 (ISSN-L)
  • 1521-4095
DOI
10.1002/adma.200801984
OpenAlex
W2152004144
Cited by
504
References
517
Citations by year
2026: 7 · 2025: 17 · 2024: 22 · 2023: 17 · 2022: 10 · 2021: 28 · 2020: 18 · 2019: 23 · 2018: 34 · 2017: 41 · 2016: 35 · 2015: 33 · 2014: 51 · 2013: 45 · 2012: 56
FWCI
16.86
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Advanced Materials (publishedVersion)
  • Deep Blue (University of Michigan) (submittedVersion)
  • SDL (submittedVersion)
  • ArTS Archivio della ricerca di Trieste (University of Trieste https://www.units.it/) (submittedVersion)
Funders
  • Massachusetts Institute of Technology
  • Ohio State University
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
  • Physical Sciences › Materials Science › Polymers and Plastics › Conducting polymers and applications
  • Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrochemical sensors and biosensors
Keywords
nanomaterials, neural interfaces, neural electrodes, biocompatibility, nanomaterial toxicity, drug delivery, neuroimaging, nanoscale transistors, nanoparticles, nanowires, carbon nanotubes, neuroprosthetics, neurostimulation

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