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Cited by 12Hemodynamic Monitoring and TherapyCardiovascular Function and Risk FactorsRenal function and acid-base balance

Influence of Mild Metabolic Acidosis on Cardiac Contractility and Isoprenaline Response in Isolated Ovine Myocardium: INFLUENCE OF ACIDOSIS ON CARDIAC CONTRACTILITY

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Schotola, Hanna, Sossalla, Samuel, Rajab, Taufiek K., Toischer, Karl, Quintel, Michael, Bauer, Martin, Schmitto, Jan D.·2011·Artificial Organs
DOI 10.1111/j.1525-1594.2011.01390.x
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Abstract

The postoperative course after major surgical procedures such as cardiothoracic operations is often accompanied by acute metabolic abnormalities due to large volume and temperature shifts. In general, those intervention-induced trauma might cause the use of catecholamines to stabilize hemodynamics. Within the cardiac community, there are still controversial discussions about standardized medical therapy to treat postoperative acidosis, for example, buffering versus nonbuffering for improving catecholaminergic response of myocardial contractility. The aim of this study was to investigate the influence of mild (and thus clinically relevant) acidosis on myocardial contractility and catecholamine response in explanted trabeculae of ovine hearts. Intact trabeculae (n = 24) were isolated from the right ventricle of healthy sheep hearts. Two different groups (group 1: pH = 7.40, n = 9 and group 2: pH = 7.20, n = 13) were investigated, and force amplitudes were measured at frequencies between 30 and 180 beats per minute and increasing catecholamine concentrations (isoprenaline 0-3 × 10(-6) mM). Force-frequency relation experiments in the presence of a physiological and/or mild acidotic pH solution showed no significant differences. Mean force amplitudes normalized to the lowest frequency showing no significant differences in force development between 0.5 and 3 Hz (n = 9 vs. 13, P = n.s.) (0.5 Hz absolute values 3.1 ± 2.6 for pH = 7.40 vs. 3.8 ± 2.6 mN/mm(2) for pH = 7.20, P = n.s.). Moreover, there was no significant difference in relaxation kinetics between the two groups. Furthermore, the experiments showed similar catecholamine responses in both groups. Force amplitudes normalized to baseline and maximum force showed no significant differences in force development between baseline and maximum isoprenaline concentrations (n = 6 vs. 9, P = n.s.) (baseline absolute values 4.3 ± 4.0 for pH = 7.40 vs. 3.9 ± 1.2 mN/mm(2) for pH = 7.20, P = n.s.). Additionally, relaxation kinetics did not show differences after catecholamine stimulation. The presented experiments revealed no significant negative inotropic effects on isometrically contracting ovine trabeculae with mild metabolic acidosis (pH = 7.2) compared with physiological pH (7.4). Additionally, similar catecholamine responses were seen in both groups. Further investigations (e.g., in vivo and/or in failing hearts with reduced compensatory reserves) will be necessary to examine optimal medical treatment for metabolic abnormalities after cardiac surgery.

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Crossref · 10.1111/j.1525-1594.2011.01390.x

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  • Increasing stimulation frequency in sheep trabeculae from 0.5 Hz to 2 Hz resulted in a 139-171% increase in force production.

    “Increasing stimulation frequency in sheep trabeculae from 0.5 Hz to 2 Hz resulted in a 139–171% increase in force production (Schotola, et al., 2011; Sossalla, et al., 2010).”

    From Small and large animal models in cardiac contraction research: advantages and disadvantages (2014) · cites this paper as Schotola, et al., 2011

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Authors
Schotola, H., Sossalla, S., Rajab, T. K., Toischer, K., Quintel, M., Bauer, M., & Schmitto, J. D.
Affiliations
  • Universitätsmedizin Göttingen (DE)
  • Brigham and Women's Hospital (US)
  • Medizinische Hochschule Hannover (DE)
Corresponding author
Schmitto, Jan D.
ORCID
Venue
Artificial Organs
Publisher
Wiley
Published
2011-11
Volume
35
Issue
11
Pages
1065-1074
ISSN
0160-564X (ISSN-L)
DOI
10.1111/j.1525-1594.2011.01390.x
OpenAlex
W1498797258
Cited by
12
References
54
Citations by year
2024: 1 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 1 · 2012: 4
FWCI
2.29
Type
journal article
Language
en
Open access
Licence
Locations
  • Artificial Organs (publishedVersion)
  • PubMed (publishedVersion)
  • GRO (submittedVersion, cc-by)
Topics
  • Health Sciences › Medicine › Surgery › Hemodynamic Monitoring and Therapy
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Nephrology › Renal function and acid-base balance
Keywords
metabolic acidosis, cardiac contractility, catecholamines, force-frequency relationship, relaxation kinetics, postoperative acidosis, sheep heart, negative inotropic effect, right ventricle, isometric contraction, catecholamine therapy
MeSH terms
Acidosis, Animals, Cardiotonic Agents, Heart, Isoproterenol, Myocardial Contraction, Myocardium, Sheep, Domestic

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