New developments in the treatment algorithm for peripheral neuropathic pain.
Abstract
Neuropathic pain often imposes a substantial and unrelenting burden on those individuals who have it; single-agent analgesics typically only reduce pain at best. Worldwide, five sets of treatment recommendations offer insight into managing neuropathic pain, including two European guidelines, one Canadian, one Latin American, and another constructed under the auspices of the International Association for the Study of Pain (IASP). The analgesics common to these guidelines are topical lidocaine, secondary amine tricyclic antidepressants, serotonin and norepinephrine dual reuptake inhibitors, calcium channel α(2)-δ ligands, tramadol, and opioid antagonists. Still, significant knowledge gaps in the treatment of neuropathic pain conditions have hampered the development of algorithms and multimodal approaches. As the evidence base expands, the addition of new comparative trial data will further refine the development of new guidance for clinical management of neuropathic pain. New alternatives for managing neuropathic pain, such as the high-concentration capsaicin patch, will enlarge the treatment armamentarium and potentially impact therapeutic guidelines.
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Such classification would also bring under consideration how therapeutic strategies now in use or under development for neuropathic pain might be applied to painful or potentially painful endometriosis.
“Such classification would also bring under consideration how therapeutic strategies now in use or under development for neuropathic pain might be applied to painful or potentially painful endometriosis [32], [33].”
From Sprouted Innervation into Uterine Transplants Contributes to the Development of Hyperalgesia in a Rat Model of Endometriosis (2012) · cites this paper as [33]
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- Authors
- de Leon-Casasola, O.
- Venue
- Pain Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-07
- Volume
- 12
- Issue
- suppl 3
- Pages
- S100-S108
- ISSN
- 1526-2375 (ISSN-L)
- 1526-4637
- OpenAlex
- W1937062320
- Cited by
- 32
- References
- 42
- Citations by year
- 2024: 1 · 2022: 1 · 2021: 2 · 2018: 1 · 2016: 4 · 2015: 5 · 2014: 1 · 2013: 7 · 2012: 8
- FWCI
- 0.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pain Medicine (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
- Keywords
- peripheral neuropathic pain, treatment algorithm, analgesic treatment, topical lidocaine, tricyclic antidepressants, serotonin-norepinephrine reuptake inhibitors, tramadol, opioid antagonists, capsaicin patch, multimodal analgesia
- MeSH terms
- Algorithms, Analgesics, Combined Modality Therapy, Drug Therapy, Combination, Humans, Neuralgia, Evidence-Based Medicine
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