The Pharmacology and Mechanism of Action of Zolpidem

Epidemiologic study of sleep disturbances and psychiatric disorders. An opportunity for prevention?

Ford, D. E. (1989) · JAMA · doi:10.1001/jama.262.11.1479 · Cited by 2,440 · see citing works

Epidemiologic Study of Sleep Disturbances and Psychiatric Disorders: An Opportunity for Prevention?

Ford, D. E. (1989) · JAMA · doi:10.1001/jama.1989.03430110069030 · Cited by 2,252 · see citing works

Pentoxifylline

Ward, A., & Clissold, S. P. (1987) · Drugs · doi:10.2165/00003495-198734010-00003 · Cited by 1,760 · see citing works

Structure and pharmacology of gamma-aminobutyric acidA receptor subtypes.

Sieghart, W. (1995) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06840-1 · Cited by 1,301 · see citing works

International Union of Pharmacology. XV. Subtypes of gamma-aminobutyric acidA receptors: classification on the basis of subunit structure and receptor function.

Barnard, E. A., Skolnick, P., Olsen, R. W., Möhler, H., Sieghart, W., Biggio, G., Bræstrup, C., Bateson, A. N., & Langer, S. Z. (1998) · PubMed · Cited by 1,204 · see citing works

Insomnia and Its Treatment: Prevalence and Correlates

Mellinger, G. D. (1985) · Archives of General Psychiatry · doi:10.1001/archpsyc.1985.01790260019002 · Cited by 1,071 · see citing works

Prevalence of sleep disorders in the Los Angeles metropolitan area

Bixler, E. O., Kales, A., Soldatos, C. R., Kales, J. D., & Healey, S. (1979) · American Journal of Psychiatry · doi:10.1176/ajp.136.10.1257 · Cited by 889 · see citing works

International Union of Pharmacology. XV. Subtypes of γ-Aminobutyric AcidA Receptors: Classification on the Basis of Subunit Structure and Receptor Function

Barnard, E. A., Skolnick, P., Olsen, R. W., Möhler, H., Sieghart, W., Biggio, G., Bræstrup, C., Bateson, A. N., & Langer, S. Z. (1998) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01363-2 · Cited by 711 · see citing works

Benzodiazepines: use, abuse, and consequences.

Woods, J. H., Katz, J. L., & Winger, G. (1992) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)00468-5 · Cited by 560 · see citing works

γ‐Aminobutyric AcidA Receptor α5‐Subunit Creates Novel Type II Benzodiazepine Receptor Pharmacology

Pritchett, D. B., & Seeburg, P. H. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb01237.x · Cited by 503 · see citing works

The Cost of Sleep-Related Accidents: A Report for the National Commission on Sleep Disorders Research

Léger, D. (1994) · SLEEP · doi:10.1093/sleep/17.1.84 · Cited by 469 · see citing works

Quaternary Structure of the Native GABAA Receptor Determined by Electron Microscopic Image Analysis

Nayeem, N., Green, T. P., Martin, I. L., & Barnard, E. A. (1994) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1994.62020815.x · Cited by 436 · see citing works

Prevalence of DSM-IV diagnostic criteria of insomnia: Distinguishing insomnia related to mental disorders from sleep disorders

Ohayon, M. M. (1997) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(97)00002-2 · Cited by 423 · see citing works

Some properties of brain specific benzodiazepine receptors: New evidence for multiple receptors

Squires, R. F., Benson, D. I., Bræstrup, C., Coupet, J., Klepner, C. A., Myers, V., & Beer, B. (1979) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(79)90341-1 · Cited by 408 · see citing works

Prevalence and treatment of insomnia in general practice

Hohagen, F., Rink, K., Käppler, C. D. O., Schramm, E., Riemann, D. W., Weyerer, S. B., & Berger, T. (1993) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/bf02190245 · Cited by 347 · see citing works

Influence of recombinant gamma-aminobutyric acid-A receptor subunit composition on the action of allosteric modulators of gamma-aminobutyric acid-gated Cl- currents.

Puia, G., Vicini, S., Seeburg, P. H., & Costa, E. (1991) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)00452-3 · Cited by 342 · see citing works

Economic effects of insomnia.

Stoller, M. K. (1995) · PubMed · Cited by 322 · see citing works

Sleep Disorders and Aging

Desforges, J. F., Prinz, P. N., Vitiello, M. V., Raskind, M. A., & Thorpy, M. J. (1990) · New England Journal of Medicine · doi:10.1056/nejm199008233230805 · Cited by 318 · see citing works

Zolpidem

Langtry, H. D., & Benfield, P. (1990) · Drugs · doi:10.2165/00003495-199040020-00008 · Cited by 298 · see citing works

Function and pharmacology of multiple GABAA receptor subunits

Lüddens, H., & Wisden, W. (1991) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(91)90495-e · Cited by 289 · see citing works

Zolpidem, a novel nonbenzodiazepine hypnotic. I. Neuropharmacological and behavioral effects.

Depoortere, H., Živković, B., Lloyd, K. G., Sanger, D. J., Perrault, G., Langer, S. Z., & Bartholini, G. (1986) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)24899-6 · Cited by 282 · see citing works

Clinical Pharmacokinetics and Pharmacodynamics of Zolpidem

Salvà, P., & Costa, J. (1995) · Clinical Pharmacokinetics · doi:10.2165/00003088-199529030-00002 · Cited by 273 · see citing works

Behavioral Pharmacology of Zolpidem Relative to Benzodiazepines A Review

Rush, C. R. (1998) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(98)00102-6 · Cited by 260 · see citing works

Zopiclone

Noble, S., Langtry, H. D., & Lamb, H. M. (1998) · Drugs · doi:10.2165/00003495-199855020-00015 · Cited by 254 · see citing works

The Diagnosis and Management of Insomnia

Oates, J. A., Wood, A. J. J., Gillin, J. C., & Byerley, W. F. (1990) · New England Journal of Medicine · doi:10.1056/nejm199001253220406 · Cited by 220 · see citing works

Cloning of cDNA sequences encoding human alpha 2 and alpha 3 gamma-aminobutyric acidA receptor subunits and characterization of the benzodiazepine pharmacology of recombinant alpha 1-, alpha 2-, alpha 3-, and alpha 5-containing human gamma-aminobutyric acidA receptors.

Hadingham, K. L., Wingrove, P. B., Bourdellès, B. L., Palmer, K. J., RAGAN, C. I., & Whiting, P. J. (1993) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)13682-1 · Cited by 214 · see citing works

Zolpidem: Distinct from Triazolam?

Lobo, B. L., & Greene, W. L. (1997) · Annals of Pharmacotherapy · doi:10.1177/106002809703100518 · Cited by 200 · see citing works

Comparative clinical profiles of triazolam versus other shorter-acting hypnotics.

Jonas, J. M., Coleman, B. S., Sheridan, A. Q., & Kalinske, R. W. (1992) · PubMed · Cited by 188 · see citing works

Pharmacological profile of the imidazopyridine zolpidem at benzodiazepine receptors and electrocorticogram in rats

Arbilla, S., Depoortere, H., George, P. G., & Langer, S. Z. (1985) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00572441 · Cited by 169 · see citing works

Zolpidem and triazolam in humans: behavioral and subjective effects and abuse liability.

Evans, S. M., Funderburk, F. R., & Griffiths, R. R. (1990) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)23193-7 · Cited by 165 · see citing works

Recent developments in the behavioral pharmacology of benzodiazepine (ω) receptors: Evidence for the functional significance of receptor subtypes

Sanger, D. J., Bénavidès, J., Perrault, G., Morel, E., Cohen, C., Joly, D., & Živković, B. (1994) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(94)90049-3 · Cited by 161 · see citing works

Differences in affinity and efficacy of benzodiazepine receptor ligands at recombinant gamma-aminobutyric acidA receptor subtypes.

Wafford, K. A., Whiting, P. J., & Kemp, J. A. (1993) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)13605-5 · Cited by 155 · see citing works

The safety and tolerability of zolpidem — an update

DARCOURT, G., Pringuey, D., Sallière, D., & Lavoisy, J. (1999) · Journal of Psychopharmacology · doi:10.1177/026988119901300109 · Cited by 139 · see citing works

Special Report From a Symposium Held by the World Health Organization and the World Federation of Sleep Research Societies: An Overview of Insomnias and Related Disorders—Recognition, Epidemiology, and Rational Management

Silva, J. A. C. E., Chase, M. H., Sartorius, N., & Roth, T. G. (1996) · SLEEP · doi:10.1093/sleep/19.5.412 · Cited by 139 · see citing works

Modifications of sleep structure induced by increasing levels of acoustic perturbation in normal subjects

Terzano, M. G., Parrino, L., Fioriti, G., Orofiamma, B., & Depoortere, H. (1990) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(90)90055-o · Cited by 125 · see citing works

Zolpidem behavioral pharmacology in baboons: self-injection, discrimination, tolerance and withdrawal.

Griffiths, R. R., Sannerud, C. A., Ator, N. A., & Brady, J. V. (1992) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)11429-8 · Cited by 112 · see citing works

High affinity [3H]zolpidem binding in the rat brain: an imidazopyridine with agonist properties at central benzodiazepine receptors

Arbilla, S., Allen, J., Wick, A. K., & Langer, S. Z. (1986) · European Journal of Pharmacology · doi:10.1016/0014-2999(86)90276-1 · Cited by 112 · see citing works

Distribution of central omega 1 (benzodiazepine1) and omega 2 (benzodiazepine2) receptor subtypes in the monkey and human brain. An autoradiographic study with [3H]flunitrazepam and the omega 1 selective ligand [3H]zolpidem.

Dennis, T., Dubois, A., Bénavidès, J., & Scatton, B. (1988) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)20029-5 · Cited by 110 · see citing works

Lack of tolerance and physical dependence upon repeated treatment with the novel hypnotic zolpidem.

Perrault, G., Morel, E., Sanger, D. J., & Zivkovic, B. (1992) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10339-x · Cited by 110 · see citing works

Oxidative metabolism of zolpidem by human liver cytochrome P450S.

Pichard‐Garcia, L., Gillet, G., Bonfils, C., Domergue, J., Thénot, J., & Maurel, P. (1995) · Drug Metabolism and Disposition · doi:10.1016/s0090-9556(25)06824-2 · Cited by 108 · see citing works

Phasic Events and Dynamic Organization of Sleep

Thorpy, M. J. (1992) · Journal of Clinical Neurophysiology · doi:10.1097/00004691-199201000-00033 · Cited by 101 · see citing works

Differences in pharmacological profiles of a new generation of benzodiazepine and non-benzodiazepine hypnotics

Perrault, G., Morel, E., Sanger, D. J., & Živković, B. (1990) · European Journal of Pharmacology · doi:10.1016/0014-2999(90)90375-g · Cited by 94 · see citing works

In vivo interaction of zolpidem with central benzodiazepine (BZD) binding sites (as labeled by [3H]Ro 15-1788) in the mouse brain. Preferential affinity of zolpidem for the omega 1 (BZD1) subtype.

Bénavidès, J., Peny, B., Dubois, A., Perrault, G., Morel, E., Živković, B., & Scatton, B. (1988) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)24071-x · Cited by 93 · see citing works

Evidence for central benzodiazepine receptor heterogeneity from behavior tests

Davies, M. F., Onaivi, E. S., Chen, S.-W., Maguire, P. A., Tsai, N. F., & Loew, G. H. (1994) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)90455-3 · Cited by 93 · see citing works

The use of the rat elevated plus-maze to discriminate between non-selective and BZ-1 (ω 1) selective, benzodiazepine receptor ligands

Griebel, G., Sanger, D. J., & Perrault, G. (1996) · Psychopharmacology · doi:10.1007/bf02246664 · Cited by 85 · see citing works

Form, frequency and burden of sleep problems in general health care: a report from the WHO Collaborative Study on Psychological Problems in General Health Care

Üstün, T. B., Privett, M. L., Lecrubier, Y., Weiller, E., Simon, G. E., Korten, A. E., Bassett, S., Maier, W., Sartorius, N., & Investigators of the WHO International Study on Psychological Problems in General Health Care (1996) · European Psychiatry · doi:10.1016/0924-9338(96)80462-7 · Cited by 84 · see citing works

Acute Zolpidem Poisoning Analysis of 344 Cases

Garnier, R., Guerault, E., Muzard, D., Azoyan, P., Chaumet-Riffaud, A.-E., & Efthymiou, M. (1994) · Journal of Toxicology Clinical Toxicology · doi:10.3109/15563659409011040 · Cited by 78 · see citing works

LIMITATIONS OF THE BENZODIAZEPINE RECEPTOR NOMENCLATURE: A PROPOSAL FOR A PHARMACOLOGICAL CLASSIFICATION AS OMEGA RECEPTOR SUBTYPES

Langer, S. Z., & Arbilla, S. (1988) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.1988.tb00629.x · Cited by 77 · see citing works

The discriminative stimulus properties of zolpidem, a novel imidazopyridine hypnotic

Sanger, D. J., & Živković, B. (1986) · Psychopharmacology · doi:10.1007/bf00174367 · Cited by 76 · see citing works

Phasic events and dynamic organization of sleep

Terzano, M. G., Halász, P., & Declerck, A. C. (1991) · Raven Press eBooks · Cited by 72 · see citing works

The Cost of Sleep-Related Accidents: A Reanalysis

Webb, W. B. (1995) · SLEEP · doi:10.1093/sleep/18.4.276 · Cited by 69 · see citing works

An Assessment of Short-Acting Hypnotics

Mendelson, W. B., & Jain, B. (1995) · Drug Safety · doi:10.2165/00002018-199513040-00005 · Cited by 66 · see citing works

Zolpidem Physical Dependence Assessed Across Increasing Doses Under a Once-Daily Dosing Regimen in Baboons

Weerts, E. M., Ator, N. A., Grech, D. M., & Griffiths, R. R. (1998) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37370-7 · Cited by 66 · see citing works

Rifampin reduces plasma concentrations and effects of zolpidem*

Villikka, K., Kivistö, K. T., Luurila, H., & Neuvonen, P. J. (1997) · Clinical Pharmacology & Therapeutics · doi:10.1016/s0009-9236(97)90082-5 · Cited by 64 · see citing works

CCD-3693: An Orally Bioavailable Analog of the Endogenous Neuroactive Steroid, Pregnanolone, Demonstrates Potent Sedative Hypnotic Actions in the Rat

Edgar, D. M., Seidel, W. F., Gee, K. W., Lan, N. C., Field, G., Xia, H., Hawkinson, J. E., Wieland, S., Carter, R. B., & Wood, P. L. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36773-4 · Cited by 63 · see citing works

Imidazopyridines in sleep disorders : a novel experimental and therapeutic approach

Sauvanet, J.-P., Langer, S. Z., Morselli, P. L., & Synthelabo, L. D. E. D. R. (1988) · Raven Press eBooks · Cited by 58 · see citing works

Expression and properties of recombinant α1β2γ2 and α5β2γ2 forms of the rat GABAA receptor

Faure-Halley, C., Graham, D., Arbilla, S., & Langer, S. Z. (1993) · European Journal of Pharmacology Molecular Pharmacology · doi:10.1016/0922-4106(93)90043-9 · Cited by 57 · see citing works

Comparative in vivo and in vitro regional selectivity of central omega (benzodiazepine) site ligands in inhibiting [3H]flumazenil binding in the rat central nervous system.

Bénavidès, J., Peny, B., Durand, A., Arbilla, S., & Scatton, B. (1992) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10428-x · Cited by 50 · see citing works

Investigation of the development of tolerance to the actions of zolpidem and midazolam

Sanger, D. J., & Zivkovic, B. (1987) · Neuropharmacology · doi:10.1016/0028-3908(87)90172-9 · Cited by 47 · see citing works

Benzodiazepine-GABAA receptor complex ligands in two models of anxiety

Nazar, M., Jessa, M., & Płaźnik, A. (1997) · Journal of Neural Transmission · doi:10.1007/bf01291890 · Cited by 46 · see citing works

Central benzodiazepine receptor occupancy by zolpidem in the human brain as assessed by positron emission tomography

Abadie, P., Rioux, P. P., Scatton, B., Zarifian, E., Barré, L., Patat, A. A., & Baron, J. (1996) · European Journal of Pharmacology · doi:10.1016/0014-2999(95)00633-8 · Cited by 46 · see citing works

gamma-Aminobutyric acidA receptor heterogeneity in rat central nervous system: studies with clonazepam and other benzodiazepine ligands.

Massotti, M., Schlichting, J., Antonacci, M. D., Giusti, P., Memo, M., Costa, E., & Guidotti, A. (1990) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)23063-4 · Cited by 46 · see citing works

Differential development of tolerance to the depressant effects of benzodiazepine and non-benzodiazepine agonists at the omega (BZ) modulatory sites of GABAA receptors

Sanger, D. (1992) · Neuropharmacology · doi:10.1016/0028-3908(92)90148-i · Cited by 44 · see citing works

A rapid screening method for the assessment of benzodiazepine receptor-related physical dependence in mice

VonVoigtlander, P. F., & Lewis, R. A. (1991) · Journal of Pharmacological Methods · doi:10.1016/0160-5402(91)90049-b · Cited by 41 · see citing works

Effects of zolpidem, a new imidazopyridine hypnotic, on the acquisition of conditioned fear in mice

Sanger, D. J., Joly, D., & Živković, B. (1986) · Psychopharmacology · doi:10.1007/bf00181243 · Cited by 41 · see citing works

Further behavioural evidence for the selective sedative action of zolpidem

Sanger, D. J., & Živković, B. (1988) · Neuropharmacology · doi:10.1016/0028-3908(88)90007-x · Cited by 40 · see citing works

A Review of the Preclinical Development of Zaleplon, a Novel Non‐Benzodiazepine Hypnotic for the Treatment of Insomnia

Beer, B., Clody, D. E., Mangano, R. M., Levner, M., Mayer, P. E., & Barrett, J. E. (1997) · CNS Drug Reviews · doi:10.1111/j.1527-3458.1997.tb00324.x · Cited by 40 · see citing works

General safety profile of zolpidem: safety in elderly, overdose and rebound effects

Allain, H., & Monti, J. M. (1997) · European Psychiatry · doi:10.1016/s0924-9338(97)80017-x · Cited by 37 · see citing works

Next day effects after nighttime treatment with zolpidem: a review

Undén, M., & Roth‐Schechter, B. F. (1996) · European Psychiatry · doi:10.1016/0924-9338(96)80465-2 · Cited by 37 · see citing works

Pharmacokinetics, brain distribution and pharmaco-electrocorticographic profile of zolpidem, a new hypnotic, in the rat.

Garrigou-Gadenne, D., Burke, J., Durand, A., Depoortere, H., Thénot, J., & Morselli, P. L. (1989) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)24153-2 · Cited by 35 · see citing works

Zolpidem Displays Heterogeneity in Its Binding to the Nonhuman Primate Benzodiazepine Receptor In Vivo

Schmid, L., Bottlaender, M., Fuseau, C., Fournier, D., Brouillet, E., & Mazière, M. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.65041880.x · Cited by 34 · see citing works

Species Differences in Regional Patterns of 3H-8-OH-DPAT and 3H-Zolpidem Binding in the Rat and Human Brain

Duncan, G. (1998) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(98)00018-5 · Cited by 33 · see citing works

Development of Stable Cell Lines Expressing Different Subtypes of Gaba A Receptors

Besnard, F., Even, Y., Itier, V., Granger, P., Partiseti, M., Avenet, P., Depoortere, H., & Graham, D. (1997) · Journal of Receptors and Signal Transduction · doi:10.3109/10799899709036596 · Cited by 31 · see citing works

Investigation of the actions of the benzodiazepine antagonists Ro 15-1788 and CGS 8216 using the schedule-controlled behavior of rats

Sanger, D. J. (1986) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(86)90137-1 · Cited by 30 · see citing works

Novel benzodiazepine receptor ligands: Palatable food intake following zolpidem, CGS 17867A, or Ro23-0364, in the rat

Yerbury, R. E., & Cooper, S. J. (1989) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(89)90504-2 · Cited by 30 · see citing works

Zolpidem self-injection with concurrent physical dependence under conditions of long-term continuous availability in baboons.

Weerts, E. M., & Griffiths, R. R. (1998) · PubMed · Cited by 30 · see citing works

Discriminative Stimulus Effects of Drugs Acting at GABAA Receptors

Sanger, D. J., Griebel, G., Perrault, G., Claustre, Y., & Schoemaker, H. (1999) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(99)00081-7 · Cited by 30 · see citing works

Zolpidem functionally discriminates subtypes of native GABAA receptors in acutely dissociated rat striatal and cerebellar neurons

Itier, V., Depoortere, H., Scatton, B., & Avenet, P. (1996) · Neuropharmacology · doi:10.1016/0028-3908(95)00158-1 · Cited by 28 · see citing works

Evaluation of the stability and quality of sleep using hjorth's descriptors

Depoortere, H., Françon, D., Granger, P., & Terzano, M. G. (1993) · Physiology & Behavior · doi:10.1016/0031-9384(93)90093-u · Cited by 27 · see citing works

Sensitivity of Cyclic Alternating Pattern to Prolonged Pharmacotherapy

Terzano, M. G., Parrino, L., Boselli, M., Spaggiari, M. C., Giovanni, G. D., & Smerieri, A. (1997) · Clinical Neuropharmacology · doi:10.1097/00002826-199710000-00010 · Cited by 24 · see citing works

Zolpidem is differentiated from triazolam in humans using a three-response drug discrimination procedure

Mintzer, M. Z., Frey, J. M., & Griffiths, R. R. (1998) · Behavioural Pharmacology · doi:10.1097/00008877-199811000-00010 · Cited by 23 · see citing works

U-90042, a sedative/hypnotic compound that interacts differentially with the GABAA receptor subtypes.

Tang, A. H., Smith, M., Carter, D. B., Im, W. B., & Pf, V. (1995) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12126-5 · Cited by 23 · see citing works

Variations of cyclic alternating pattern rate and homeostasis of sleep organization: A controlled study on the effects of white noise and zolpidem

Terzano, M. G., Parrino, L., Fioriti, G., Farolfi, A., Spaggiari, M. C., Anelli, S., & Arcelloni, T. (1988) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(88)90218-3 · Cited by 23 · see citing works

Pyrazoloquinolines and zolpidem: Effects on hypertonic saline consumption in rehydrating rats

Cooper, S. J., & Desa, A. (1988) · Drug Development Research · doi:10.1002/ddr.430140207 · Cited by 21 · see citing works

Potency of several type I-benzodiazepine receptor ligands for inhibition of [3H]flunitrazepam binding in different rat brain tissues

Sieghart, W., & Schlerka, W. (1991) · European Journal of Pharmacology · doi:10.1016/0014-2999(91)90371-v · Cited by 20 · see citing works

Discriminative Stimulus Effects of Zolpidem in Pentobarbital-Trained Subjects: I. Comparison with Triazolam in Rhesus Monkeys and Rats

Rowlett, J. K., & Woolverton, W. L. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36360-8 · Cited by 20 · see citing works

Efficacy of zolpidem in insomnia

Rg, P., Terzano, M., Parrino, L., & Boyer, P. (1997) · European Psychiatry · doi:10.1016/s0924-9338(97)80015-6 · Cited by 20 · see citing works

Short-term safety profile of zolpidem: objective measures of cognitive effects

DeClerk, A. C., & Bisserbe, J. (1997) · European Psychiatry · doi:10.1016/s0924-9338(97)80016-8 · Cited by 16 · see citing works

Comparison of benzodiazepine (BZ) receptor agonists in two rodent activity tests

Bayley, P. J., Bentley, G., Jackson, A. E., Williamson, D., & Dawson, G. R. (1996) · Journal of Psychopharmacology · doi:10.1177/026988119601000305 · Cited by 15 · see citing works

Effect of the benzodiazepine receptor agonist, zolpidem, on palatable fluid consumption in the rat

Stanhope, K. J., Roe, S., Dawson, G. R., Draper, F., & Jackson, A. E. (1993) · Psychopharmacology · doi:10.1007/bf02245521 · Cited by 12 · see citing works

Growing aspects of hypnotic drugs

Bartolini, G. (1988) · Cited by 11 · see citing works

Binding Profiles and Physical Dependence Liabilities of Selected Benzodiazepine Receptor Ligands

Richards, J. G., & Martin, J. R. (1998) · Brain Research Bulletin · doi:10.1016/s0361-9230(97)00370-5 · Cited by 10 · see citing works

Memory processes and memory systems: Fractionation of human memory

Hijman, R. (1996) · Neuroscience Research Communications · doi:10.1002/(sici)1520-6769(199611)19:3 · Cited by 2 · see citing works

Comment: Zolpidem: Distinct from Triazolam?

Holt, R. J., & Allard, S. (1997) · Annals of Pharmacotherapy · doi:10.1177/106002809703101125 · Cited by 1 · see citing works

Zolpidem: an update of its pharmacology, therapeutic efficacy and tolerability in the treatment of insomnia

Holm, K. J., & Goa, K. L. (2000) · Drugs · doi:10.2165/00003495-200059040-00014 · Cited by 317 · see citing works

TPA023 [7-(1,1-Dimethylethyl)-6-(2-ethyl-2 H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine], an Agonist Selective for α2- and α3-Containing GABAA Receptors, Is a Nonsedating Anxiolytic in Rodents and Primates

Atack, J. R., Wafford, K. A., Tye, S. J., Cook, S. M., Sohal, B., Pike, A., Sur, C., Melillo, D., Bristow, L., Bromidge, F., et al. (2006) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.089920 · Cited by 188 · see citing works

Increased Risk of Adverse Pregnancy Outcomes in Women Receiving Zolpidem During Pregnancy

Wang, L., Lin, H.-C., Lin, C.-C., Chen, Y.-H., & Lin, H.-C. (2010) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2010.97 · Cited by 107 · see citing works

Imidazopyridine-based selective and multifunctional ligands of biological targets associated with psychiatric and neurodegenerative diseases

Vanda, D., Zajdel, P., & Soural, M. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.111569 · Cited by 97 · see citing works

Zolpidem: Efficacy and Side Effects for Insomnia

Edinoff, A. N., Wu, N. W., Ghaffar, Y. T., Prejean, R., Gremillion, R., Cogburn, M., Chami, A. A., Kaye, A. M., & Kaye, A. D. (2021) · Health Psychology Research · doi:10.52965/001c.24927 · Cited by 89 · see citing works

Next-day residual effects of hypnotics in DSM-IV primary insomnia: a driving simulator study with simultaneous electroencephalogram monitoring

Staner, L., Ertle, S., Boeijinga, P. H., Rinaudo, G., Arnal, M. A., Muzet, A. G., & Luthringer, R. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0082-8 · Cited by 82 · see citing works

Palatability-dependent appetite and benzodiazepines: new directions from the pharmacology of GABAA receptor subtypes

Cooper, S. J. (2005) · Appetite · doi:10.1016/j.appet.2005.01.003 · Cited by 73 · see citing works

Compulsive activity and anterograde amnesia after zolpidem use

Tsai, M., Tsai, Y., & Huang, Y. (2007) · Clinical Toxicology · doi:10.1080/15563650600956741 · Cited by 61 · see citing works

Design, synthesis, and pharmacological evaluation of new neuroactive pyrazolo[3,4-b]pyrrolo[3,4-d]pyridine derivatives with in vivo hypnotic and analgesic profile

Menegatti, R., Silva, G. M. S., Zapata‐Sudo, G., Raimundo, J. M., Sudo, R. T., Barreiro, E. J., & Fraga, C. A. M. (2005) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2005.08.042 · Cited by 49 · see citing works

A Novel Clinical Pattern of Visual Hallucination After Zolpidem Use

Tsai, M., Huang, Y., & Wu, P. (2003) · Journal of Toxicology Clinical Toxicology · doi:10.1081/clt-120025354 · Cited by 47 · see citing works

Pharmacodynamic profile of Zaleplon, a new non‐benzodiazepine hypnotic agent

Patat, A. A., Paty, I., & Hindmarch, I. (2001) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.310 · Cited by 45 · see citing works

The behavioral pharmacology of zolpidem: evidence for the functional significance of α1-containing GABAA receptors

Fitzgerald, A. C., Wright, B. T., & Heldt, S. A. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3457-x · Cited by 42 · see citing works

The role of the GABAergic system on insomnia

Varinthra, P., Anwar, S. N. M. N., Shih, S.-C., & Liu, I. Y. (2024) · Tzu Chi Medical Journal · doi:10.4103/tcmj.tcmj_243_23 · Cited by 40 · see citing works

Synthesis of new heterocyclic compounds based on pyrazolopyridine scaffold and evaluation of their neuroprotective potential in MPP + -induced neurodegeneration

Jouha, J., Loubidi, M., Bouali, J., Hamri, S., Hafid, A., Suzenet, F., Guillaumet, G., Dağcı, T., Khouili, M., Köse, F. A., et al. (2017) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.02.019 · Cited by 37 · see citing works

A selanylimidazopyridine (3-SePh-IP) reverses the prodepressant- and anxiogenic-like effects of a high-fat/high-fructose diet in mice

Veloso, I. C., Delanogare, E., Machado, A. E., Braga, S. P., Rosa, G. K., Bem, A. F. D., Rafique, J., Saba, S., da Trindade, R. N., Galetto, F. Z., et al. (2020) · Journal of Pharmacy and Pharmacology · doi:10.1093/jpp/rgaa070 · Cited by 37 · see citing works

GABAA Receptors: Autoradiographic Localization of Different Ligand Sites and Identification of Subtypes of the Benzodiazepine Binding Site

Sur, C., & Atack, J. R. (2003) · Humana Press eBooks · doi:10.1385/1-59259-118-3:39 · Cited by 36 · see citing works

Zolpidem use and risk of suicide: A systematic review and meta-analysis

Khan, H., Garg, A., Yasmeen, Agarwal, N. B., YADAV, D. K., Khan, M. A., & Hussain, S. (2022) · Psychiatry Research · doi:10.1016/j.psychres.2022.114777 · Cited by 41 · see citing works

A Double-Blind Comparative Study of Zolpidem versus Zopiclone in the Treatment of Chronic Primary Insomnia

Tsutsui, S., & Zolpidem Study Group (2001) · Journal of International Medical Research · doi:10.1177/147323000102900303 · Cited by 32 · see citing works

Efficacy and Safety of Zolpidem Administered ???As Needed??? in Primary Insomnia

Allain, H., Arbus, L., & Sch??ck, S. (2001) · Clinical Drug Investigation · doi:10.2165/00044011-200121060-00001 · Cited by 31 · see citing works

Reply to the commentary by Ben‐Ari and Delpire: Bumetanide and neonatal seizures: Fiction versus reality

Löscher, W., & Kaila, K. (2021) · Epilepsia · doi:10.1111/epi.16866 · Cited by 22 · see citing works

Sedation and antinociception induced by a new pyrazolo[3,4-b]pyrrolo[3,4-d]pyridine derivative (LASSBio-873) is modulated by activation of muscarinic receptors

Mendes, T. C. F., Raimundo, J. M., Nascimento-Júnior, N. M., Fraga, C. A. M., Barreiro, E. J., Sudo, R. T., & Zapata‐Sudo, G. (2009) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2009.07.008 · Cited by 21 · see citing works

Determination of zolpidem in human plasma by liquid chromatography–tandem mass spectrometry for clinical application

Byeon, J.-Y., Lee, H.-I., Lee, Y.-J., Lee, J., Kim, S., Kim, Y., Na, H. S., Jang, C., & Lee, S. (2015) · Journal of Chromatography B · doi:10.1016/j.jchromb.2015.02.004 · Cited by 20 · see citing works

Herb‐drug interactions: A short review on central and peripheral nervous system drugs

Bernardo, J., & Valentão, P. (2024) · Phytotherapy Research · doi:10.1002/ptr.8120 · Cited by 19 · see citing works

Effects of steady-state clarithromycin on the pharmacokinetics of zolpidem in healthy subjects

Lee, C., Jung, E. H., Byeon, J.-Y., Kim, S., Jang, C., Lee, Y. J., & Lee, S. (2019) · Archives of Pharmacal Research · doi:10.1007/s12272-019-01201-5 · Cited by 19 · see citing works

Recent Advances of Indium(III) Chloride Catalyzed Reactions in Organic Synthesis

Datta, M. (2021) · ChemistrySelect · doi:10.1002/slct.202003828 · Cited by 18 · see citing works

Pharmacotherapy of Insomnia: Focus on Zolpidem Extended Release

Monti, J. M., Spence, D. W., Pandi-Perumal, S. R., Langer, S. Z., & Hardeland, R. (2009) · Clinical Medicine Therapeutics · doi:10.4137/cmt.s2040 · Cited by 16 · see citing works

Antiaggressive Effects of Zolpidem and Zopiclone in Agonistic Encounters Between Male Mice

Martín‐López, M., & Navarro, J. F. (2002) · Aggressive Behavior · doi:10.1002/ab.80013 · Cited by 16 · see citing works

The influences of CYP2C9*1/*3 genotype on the pharmacokinetics of zolpidem

Byeon, J.-Y., Kim, Y., Kim, S., Lee, C., Jung, E.-H., Chae, W.-K., Jang, C., Lee, S., & Lee, Y. J. (2018) · Archives of Pharmacal Research · doi:10.1007/s12272-018-1070-y · Cited by 15 · see citing works

Relationship between plasma exposure of zolpidem and CYP2D6 genotype in healthy Korean subjects

Jung, E. H., Lee, C., Byeon, J.-Y., Shin, H.-B., Oh, K.-Y., Cho, C., Lim, C. W., Jang, C., Lee, S., & Lee, Y. J. (2020) · Archives of Pharmacal Research · doi:10.1007/s12272-020-01250-1 · Cited by 15 · see citing works

The effect of zolpidem on cognitive function and postural control at high altitude

Bouzat, P., Séchaud, G., Banco, P., Davranche, K., Casini, L. A., Baillieul, S., Manhes, P., Botrè, F., Mazzarino, M., de la Torre, X., et al. (2018) · SLEEP · doi:10.1093/sleep/zsy153 · Cited by 14 · see citing works

Synthesis of pyrazolo[3,4-b]pyrrolo[3,4-d]pyridine derivatives via Aza-Diels–Alder reaction: evaluation of torsion effect of pyrazoylimines

Wang, L., Uramaru, N., & Wong, F. F. (2014) · Tetrahedron · doi:10.1016/j.tet.2014.08.013 · Cited by 14 · see citing works

Exploring the synthetic utility of 1-alkynylimidazoles: regiocontrolled cyclization to diverse imidazoazines and imidazoazoles

Laroche, C., Gilbreath, B., & Kerwin, S. M. (2014) · Tetrahedron · doi:10.1016/j.tet.2014.04.099 · Cited by 14 · see citing works

New perspectives for the treatment of disorders of sleep and arousal

Sanger, D. J., Soubrane, C., & Scatton, B. (2007) · Annales Pharmaceutiques Françaises · doi:10.1016/s0003-4509(07)90046-2 · Cited by 14 · see citing works

[Sleep related eating disorders as a side effect of zolpidem].

Valiensi, S. M., Cristiano, E., Martínez, O. A., Reisin, R. C., & Alvarez, F. (2010) · PubMed · Cited by 13 · see citing works

Effects of genetic polymorphisms of CYP2C19 on the pharmacokinetics of zolpidem

Byeon, J.-Y., Kim, Y., Kim, S., Lee, C., Jung, E.-H., Chae, W.-K., Jang, C., Lee, S., & Lee, Y. J. (2018) · Archives of Pharmacal Research · doi:10.1007/s12272-018-1065-8 · Cited by 11 · see citing works

Indium(III) chloride/silica gel catalyzed synthesis of pyrazolo[3,4- b ]pyrrolo[3,4- d ]pyridines

Yen, W., Liu, P., Uramaru, N., Lin, H.-Y., & Wong, F. F. (2015) · Tetrahedron · doi:10.1016/j.tet.2015.09.042 · Cited by 11 · see citing works

From orexin receptor agonist YNT-185 to novel antagonists with drug-like properties for the treatment of insomnia

Mezeiová, E., Janočková, J., Konecny, J., Kobrlová, T., Benková, M., Doležal, R., Prchal, L., Karasova-Zdarova, J., Soukup, O., & Korábečný, J. (2020) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2020.104179 · Cited by 9 · see citing works

Synthesis of 3-aryl-2-phosphinoimidazo[1,2- a ]pyridine ligands for use in palladium-catalyzed cross-coupling reactions

Tran, R. Q., Jacoby, S. A., Roberts, K. E., Swann, W. A., Harris, N. W., Dinh, L. P., Denison, E. L., & Yet, L. (2019) · RSC Advances · doi:10.1039/c9ra02200g · Cited by 8 · see citing works

Metal-free, Tf2NH-catalyzed 1, 6-conjugate addition of imidazopyridine to para-quinone methides: Easy access to C3-functionalized triarylmethane imidazopyridine

Khonde, N. S., Said, M. S., Sabane, J. K., Gajbhiye, J. M., & Kumar, P. (2021) · Tetrahedron · doi:10.1016/j.tet.2021.132510 · Cited by 8 · see citing works

α-Subunit selective modulators of GABAAreceptor function as CNS therapeutics

Hamilton, N. M., & Cooke, A. (2002) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.12.10.1491 · Cited by 8 · see citing works

Occurrence of involuntary movements after prolonged misuse of zolpidem: a case report

Ricciardulli, S., Lattanzi, L., Barbuti, M., Ceravolo, R., & Perugi, G. (2022) · International Clinical Psychopharmacology · doi:10.1097/yic.0000000000000443 · Cited by 7 · see citing works

Pharmacological profile and clinical effect of zolpidem (Myslee tablets), a hypnotic agent.

Shirakawa, K. (2002) · Folia Pharmacologica Japonica · doi:10.1254/fpj.119.111 · Cited by 7 · see citing works

Psychiatric Morbidity in Dependent Z-Drugs and Benzodiazepine Users

Lin, Y. Q., Tang, W. K., Liang, H. J., Tang, A., & Ungvari, G. S. (2016) · International Journal of Mental Health and Addiction · doi:10.1007/s11469-016-9679-x · Cited by 6 · see citing works

Chronic Pain

Stanos, S. P., Tyburski, M. D., & Harden, R. N. (2020) · Elsevier eBooks · doi:10.1016/b978-0-323-62539-5.00037-0 · Cited by 3 · see citing works

Detoxification of high-dose zolpidem using phenobarbital and gabapentin: two case reports

Beyraghi, N., Shamsi, A., & Farrokhian, A. (2016) · Archives of Psychiatry and Psychotherapy · doi:10.12740/app/66307 · Cited by 3 · see citing works

Zolpidem withdrawal seizure in an Iranian young woman: A case presentation.

Hadinezhad, P., & Hosseini, S. H. (2021) · Europe PMC (PubMed Central) · doi:10.22088/cjim.12.0.376 · Cited by 3 · see citing works

Sedative‐Hypnotics

Vida, J. A., & Yevich, J. P. (2003) · Burger's Medicinal Chemistry and Drug Discovery · doi:10.1002/0471266949.bmc098 · Cited by 2 · see citing works

Bicyclic Pyridines Containing Ring‐Junction Nitrogen

Yet, L. (2018) · doi:10.1002/9781118686263.ch13 · Cited by 2 · see citing works

Conductas anormales durante el sueño y uso de zolpidem

Bedoya, R. J. H., & Yamal, J. D. C. (2015) · Psiquiatría Biológica · doi:10.1016/j.psiq.2014.12.001 · Cited by 1 · see citing works

Chronic Pain

Wu, Y. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-47904-2.00037-4 · Cited by 1 · see citing works

Chronic Pain

Stanos, S. P., Tyburski, M. D., & Harden, R. N. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-0884-4.10042-4 · Cited by 1 · see citing works

Pharmacological principles for safe benzodiazepine and Z-drug dose reduction

Horowitz, M., Lamberson, N., Brandt, J., Framer, A., Shapiro, B., Sørensen, A., Cadogan, C., Ritvo, A., & Taylor, D. (2026) · Psychological Medicine · doi:10.1017/s0033291726104887

An unusual presentation of visual hallucinations with zolpidem: a case report

Krishna, P., & Mabu, S. (2015) · International Journal of Basic & Clinical Pharmacology · doi:10.5455/2319-2003.ijbcp20150411

Awareness Of Anti Insomnia Therapy With Zolpidem Among Dental Students

DhanrajGanapathy (2021) · International Journal of Dentistry and Oral Science · doi:10.19070/2377-8075-21000411

Design and synthesis of small organic molecules to stabilize ALS-associated SOD1 mutants

Schirmacher, R. (2021) · doi:10.53846/goediss-8689

Seizure Occurring 4 Days after Discontinuation of Long-term High-dose Zolpidem

Kang, K., Kim, M.-K., Hong, J. H., Jung, J., & Kang, K. W. (2023) · Journal of the Korean Neurological Association · doi:10.17340/jkna.2023.3.9

Z-Drugs: A Culpable in Drug-Facilitated Crimes and Sexual Assault

Sharma, R. K., & Sharma, V. (2025) · Springer proceedings in earth and environmental sciences · doi:10.1007/978-3-031-93444-5_75

Zolpidem-induced synaptic disruption and multi-omics alterations in human cerebral organoids under simulated microgravity

Park, Y., Hong, J., Lee, S., Lee, J., Jung, S., Kim, S. S., Park, S. B., Jo, J. H., Im, J., Seo, J. S., et al. (2026) · Life Sciences in Space Research · doi:10.1016/j.lssr.2026.10.005

BindingDB Entry 50009606: Imidazopyridine-based selective and multifunctional ligands of biological targets associated with psychiatric and neurodegenerative diseases.

BindingDB (2021) · UC San Diego · doi:10.7270/q2h41vxg

Zolpidem Extended-Release

Neubauer, D. N. (2006) · CNS Drugs · doi:10.2165/00023210-200620050-00008 · Cited by 4 · see citing works

Zolpidem in the treatment of insomnia: Mechanism of action, risk of dependence, and withdrawal syndrome

Sławińska, J., Mielnicka, W., Mikołajczyk, J., Hawajski, A., Nowak, J., Mieruszyńska, S., Szeidl, O., Kołodziejska, M., Lewandowski, M., & Cupiał, A. (2026) · Pharmacotherapy in Psychiatry and Neurology · doi:10.17219/fpn/225353

Zolpidem ???As Needed'

Cluydts, R. (2004) · CNS Drugs · doi:10.2165/00023210-200418001-00008

[Zolpidem].

Taéron, C. (2006) · PubMed

The Analgesic Properties of Zolpidem

Puthiyathu, M., Greenspan, H. N., Levitt, W., Riccardi, G., Montemurro, N., Nandu, B., & Waseem, S. (2013) · Psychiatric Annals · doi:10.3928/00485713-20130306-02 · Cited by 1 · see citing works