The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Cardiovascular Protective Effects of Resveratrol
Abstract
Resveratrol (3,4′,5‐trihydroxy‐trans‐stilbene), a phytoalexin found in grape skins, peanuts, and red wine, has been reported to have a wide range of biological and pharmacological properties. It has been speculated that at low doses (such as consumed in the common diet) resveratrol may have cardioprotective activity. In this article we describe recent in vitro and in vivo studies in animal models. The results of these studies suggest that resveratrol modulates vascular cell function, inhibits LDL oxidation, suppresses platelet aggregation and reduces myocardial damage during ischemia‐reperfusion. Although the reported biological data indicate that resveratrol is a highly promising cardiovascular protective agent, more studies are needed to establish its bioavailability and in vivo cardioprotective effects, particularly in humans.
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Cites
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
Howitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W., Lavu, S., Wood, J. G., Zipkin, R. E., Chung, P., Kisielewski, A., Zhang, L.-L., et al. (2003) · Nature · doi:10.1038/nature01960 · Cited by 3,796
Concentration of the Phytoalexin Resveratrol in Wine
Siemann, E. H., & Creasy, L. L. (1992) · American Journal of Enology and Viticulture · doi:10.5344/ajev.1992.43.1.49 · Cited by 719
Cited by
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Baur, J. A., & Sinclair, D. A. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2060 · Cited by 3,958
Rivera, L., Morón, R., Zarzuelo, A., & Galisteo, M. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.11.027 · Cited by 391
Kitada, M., Kume, S., Imaizumi, N., & Koya, D. (2011) · Diabetes · doi:10.2337/db10-0386 · Cited by 345
Coumarin hybrids as novel therapeutic agents
Sandhu, S., Bansal, Y., Silakari, O., & Bansal, G. (2014) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2014.05.032 · Cited by 296
Wong, R. H. X., Howe, P. R. C., Buckley, J. D., Coates, A. M., Kunz, I., & Berry, N. M. (2011) · Nutrition, Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2010.03.003 · Cited by 277
Metadata
- Authors
- Bradamante, S., Barenghi, L., & Villa, A.
- Venue
- Cardiovascular Drug Reviews
- Publisher
- Wiley
- Published
- 2004-09
- Volume
- 22
- Issue
- 3
- Pages
- 169-188
- ISSN
- 0897-5957 (ISSN-L)
- 1527-3466
- OpenAlex
- W2067644861
- Cited by
- 528
- References
- 2
- FWCI
- 7.12
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bradamante, S., Barenghi, L., & Villa, A. (2004). Cardiovascular Protective Effects of Resveratrol. Cardiovascular Drug Reviews. https://doi.org/10.1111/j.1527-3466.2004.tb00139.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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