Acute resveratrol supplementation improves flow-mediated dilatation in overweight/obese individuals with mildly elevated blood pressure
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Background and aims Flow-mediated dilatation of the brachial artery (FMD) is a biomarker of endothelial function and cardiovascular health. Impaired FMD is associated with several cardiovascular risk factors including hypertension and obesity. Various food ingredients such as polyphenols have been shown to improve FMD. We investigated whether consuming resveratrol, a polyphenol found in red wine, can enhance FMD acutely and whether there is a dose-response relationship for this effect.Methods and results 19 overweight/obese (BMI 25-35 kg m(-2)) men or post-menopausal women with untreated borderline hypertension (systolic BP: 130-160 mmHg or diastolic BP: 85-100 mmHg) consumed three doses of resveratrol (resVida™ 30, 90 and 270 mg) and a placebo at weekly intervals in a double-blind, randomized crossover comparison. One hour after consumption of the supplement, plasma resveratrol and FMD were measured. Data were analyzed by linear regression versus log(10) dose of resveratrol. 14 men and 5 women (age 55 ± 2 years, BMI 28.7 ± 0.5 kg m(-2), BP 141 ± 2/89 ± 1 mmHg) completed this study. There was a significant dose effect of resveratrol on plasma resveratrol concentration (P < 0.001) and on FMD (P < 0.01), which increased from 4.1 ± 0.8% (placebo) to 7.7 ± 1.5% after 270 mg resveratrol. FMD was also linearly related to log(10) plasma resveratrol concentration (P < 0.01).Conclusion Acute resveratrol consumption increased plasma resveratrol concentrations and FMD in a dose-related manner. This effect may contribute to the purported cardiovascular health benefits of grapes and red wine.
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In obese humans, one week of resveratrol supplementation dose-dependently improved endothelial function and cardiovascular health.
“Also in human obese subjects endothelial function and cardiovascular health, dose-dependently improved after one week of resveratrol supplementation (Wong et al., 2010).”
From Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans (2011) · cites this paper as Wong et al., 2010
Wong et al. enrolled 19 overweight/obese patients and postmenopausal women (BMI 25-35 kg/m2, aged 30-70 years) with blood hypertension in a placebo-controlled, double-blind, randomized crossover study.
“In the same year, Wong and colleagues in their placebo-controlled, double-blind, randomized crossover study enrolled 19 overweight/obese patients and postmenopausal women (BMI 25–35 kg/m2, aged 30–70 years) with blood hypertension [34].”
From The Role of Resveratrol Administration in Human Obesity (2021) · cites this paper as [34]
At 270 mg once daily, flow-mediated dilation (FMD) of the brachial artery increased in a dose-related manner.
“At the dose of 270 mg administered once a day, flow-mediated dilation (FMD) of the brachial artery increased in a dose-related manner [34].”
From The Role of Resveratrol Administration in Human Obesity (2021) · cites this paper as [34]
In Wong et al.'s study, there was a linear relationship between the dose of resveratrol administered and its plasma concentrations.
“The results of this study showed a linear relationship between the dose of resveratrol administered and its plasma concentrations.”
From The Role of Resveratrol Administration in Human Obesity (2021) · cites this paper as [34]
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- Authors
- Wong, R. H. X., Howe, P. R. C., Buckley, J. D., Coates, A. M., Kunz, I., & Berry, N. M.
- Affiliations
- University of South Australia (AU)
- DSM (Switzerland) (CH)
- Corresponding author
- Wong, R.H.X.
- Howe, P.R.C.
- Buckley, J.D.
- Coates, A.M.
- Kunz, I.
- Berry, N.M.
- Venue
- Nutrition, Metabolism and Cardiovascular Diseases
- Publisher
- Elsevier BV
- Published
- 2011-11
- Volume
- 21
- Issue
- 11
- Pages
- 851-856
- ISSN
- 0939-4753 (ISSN-L)
- OpenAlex
- W2158518544
- Cited by
- 277
- References
- 33
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 8 · 2023: 8 · 2022: 14 · 2021: 18 · 2020: 15 · 2019: 16 · 2018: 18 · 2017: 22 · 2016: 23 · 2015: 22 · 2014: 25 · 2013: 42 · 2012: 22
- FWCI
- 9.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Nutrition Metabolism and Cardiovascular Diseases (publishedVersion)
- PubMed (publishedVersion)
- UEA Digital Repository (University of East Anglia) (acceptedVersion)
- UniSA Research Outputs Repository (University of South Australia) (submittedVersion)
- Funders
- DNP-DSM Nutritional Products, Kaiseraugst, Switzerland
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Keywords
- resveratrol, flow-mediated dilation, endothelial function, borderline hypertension, obesity, overweight, polyphenols, dose-response relationship, red wine, cardiovascular health
- MeSH terms
- Resveratrol, Brachial Artery, Cardiovascular Diseases, Dose-Response Relationship, Drug, Double-Blind Method, Endothelium, Vascular, Female, Humans, Hypertension, Male, Middle Aged, Obesity, Placebos, Risk Factors, Stilbenes, Vasodilation, Cross-Over Studies, Dietary Supplements, Overweight
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