The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Placebo‐Controlled Pilot Study of Centromedian Thalamic Stimulation in Treatment of Intractable Seizures
Abstract
Summary: Stimulation of centromedian (CM) thalamic nuclei has been proposed as a treatment for seizures. We implanted programmable subcutaneous (s.c.) stimulators into CM bilaterally in 7 patients with intractable epilepsy to test feasibility and safety. Stimulation was on or off in 3‐month blocks, with a 3‐month washout period in a double‐blind, cross‐over protocol. Stimuli were delivered as 9O‐μs pulses at 65 pulses/s, 1 min of each 5 min for 2 h/day, with voltage set to half the sensory threshold. Stimulation was safe and well‐tolerated, with a mean reduction of tonic‐clonic seizure frequency of 30% with respect to baseline when stimulator was on versus a decrease of 8% when the stimulator was off. There was no improvement in total number of generalized seizures with stimulation, and treatment differences were not statistically significant. Stimulation at low intensity did not alter the EEG acutely, but high‐intensity stimulation induced slow waves or 2–3 Hz spike‐waves with ipsilateral frontal maximum. In an open‐label follow‐up segment with stimulator trains continuing for 24 h/day, 3 of 6 patients reported at least a 50% decrease in seizure frequency. There were no side effects. This pilot project demonstrated the feasibility of controlled study of thalamic stimulation in epilepsy, but further study will be needed to demonstrate efficacy.
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Citations
Cites
Parameters for direct cortical electrical stimulation in the human: histopathologic confirmation
Gordon, B., Lesser, R. P., Rance, N. E., Hart, J., Webber, R., Uematsu, S., & Fisher, R. S. (1990) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(90)90082-u · Cited by 232
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Cited by
Electrical stimulation of the anterior nucleus of thalamus for treatment of refractory epilepsy
Fisher, R., Salanova, V., Witt, T., Worth, R., Henry, T., Gross, R., Oommen, K., Osorio, I., Nazzaro, J., Labar, D., et al. (2010) · Epilepsia · doi:10.1111/j.1528-1167.2010.02536.x · Cited by 1,918
Self-citationElectrical brain stimulation for epilepsy
Fisher, R. S., & Velasco, A. L. (2014) · Nature Reviews Neurology · doi:10.1038/nrneurol.2014.59 · Cited by 402
Self-citationEpileptic seizure prediction and control
Iasemidis, L. D. (2003) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2003.810705 · Cited by 363
Deep brain stimulation in epilepsy with particular reference to the subthalamic nucleus
Chabardès, S., Kahane, P., Minotti, L., Koudsie, A., Hirsch, E., & Benabid, A. (2002) · Epileptic Disorders · doi:10.1684/j.1950-6945.2002.tb00549.x · Cited by 304
Vagus nerve stimulation for intractable epilepsy: a review
McLachlan, R. S. (1997) · Journal of Clinical Neurophysiology · doi:10.1097/00004691-199709000-00002 · Cited by 89
Metadata
- Authors
- Fisher, R. S., Uematsu, S., Krauss, G. L., Cysyk, B. J., McPherson, R., Lesser, R. P., Gordon, B., Schwerdt, P., & Rise, M.
- Venue
- Epilepsia
- Publisher
- Wiley
- Published
- 1992-09
- Volume
- 33
- Issue
- 5
- Pages
- 841-851
- ISSN
- 0013-9580 (ISSN-L)
- 1528-1167
- OpenAlex
- W1966617461
- Cited by
- 383
- References
- 1
- FWCI
- 1.37
- Type
- journal article
- Language
- en
- Open access
- closed
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- Fisher, R. S., Uematsu, S., Krauss, G. L., Cysyk, B. J., McPherson, R., Lesser, R. P., Gordon, B., Schwerdt, P., & Rise, M. (1992). Placebo‐Controlled Pilot Study of Centromedian Thalamic Stimulation in Treatment of Intractable Seizures. Epilepsia. https://doi.org/10.1111/j.1528-1157.1992.tb02192.x
Data sources
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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