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Cited by 148Epilepsy research and treatmentPharmacological Effects and Toxicity StudiesDiet and metabolism studies

Stiripentol: Efficacy and Tolerability in Children with Epilepsy

Perez, J., Chiron, C., Musial, C., Rey, E., Blehaut, H., D'Athis, P., Vincent, J., Dulac, O.·1999·Epilepsia
DOI 10.1111/j.1528-1157.1999.tb02048.x
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Abstract

Summary: Purpose: Stiripentol (STP) is a new antiepileptic drug (AED) that inhibits cytochrome P 450′ resulting in increased plasma concentrations of concomitant AEDs. The efficacy and tolerability of STP as an add‐on therapy in children were assessed. Methods: Two hundred twelve patients with refractory epilepsy, aged from 1 month to 20.5 years, received STP either in a single‐blind, placebo‐controlled trial (108 patients) or in a further open trial (104 other patients selected by epilepsy syndrome for possible efficacy based on the results of the previous trial). Results: Among the 97 patients who could be analyzed for efficacy in the placebo‐controlled study, the median seizure frequency was lower at 3 months with STP than with the placebo (p > 0.0001); 49% responded to the drug, including 10% who became seizure free. Patients with partial epilepsy had the highest response rate (57%). Results were confirmed in the open study where 68% of the 91 patients receiving STP responded at 3 months. These patients were mainly those with partial epilepsy (73%) who were receiving carbamazepine (CBZ) (75%) as comedication (p > 0.001). Ten of the 20 children with severe myoclonic epilepsy in infancy also responded with clobazam (CLB) as comedication. Efficacy was sustained long term in 74% of the 94 patients still receiving STP at a mean 30‐month follow‐up. Adverse events were reported in 48% of the 212 patients, mainly anorexia and loss of weight, but these events required STP discontinuation in only nine cases. Side effects were minimized in the open trial by optimizing the dose of comedication. Conclusions: STP seems to be a promising add‐on drug, particularly when combined with CBZ in patients with partial childhood epilepsy refractory to vigabatrin (VGB) and with CLB in patients with severe myoclonic epilepsy in infancy.

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Crossref · 10.1111/j.1528-1157.1999.tb02048.x

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  • Stiripentol was more effective, in association with clobazam, in individuals with Dravet syndrome.

    “Stiripentol was more effective, in association with clobazam, in individuals with Dravet syndrome 194 .”

    From Developmental and epileptic encephalopathies (2024) · cites this paper as [194]

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Authors
Perez, J., Chiron, C., Musial, C., Rey, E., Blehaut, H., D'Athis, P., Vincent, J., & Dulac, O.
Affiliations
  • Inserm (FR)
  • Hôpital Saint-Vincent-de-Paul (FR)
Corresponding author
Chiron, C.
ORCID
Venue
Epilepsia
Publisher
Wiley
Published
1999-11
Volume
40
Issue
11
Pages
1618-1626
ISSN
  • 0013-9580 (ISSN-L)
  • 1528-1167
DOI
10.1111/j.1528-1157.1999.tb02048.x
OpenAlex
W2040934129
Cited by
148
References
33
Citations by year
2026: 2 · 2025: 6 · 2024: 7 · 2023: 5 · 2022: 6 · 2021: 2 · 2020: 9 · 2019: 12 · 2018: 5 · 2017: 5 · 2016: 5 · 2015: 5 · 2014: 7 · 2013: 15 · 2012: 10
FWCI
1.65
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 2101 d)
Locations
  • Epilepsia (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
  • Health Sciences › Medicine › Physiology › Diet and metabolism studies
Keywords
stiripentol, adjunctive antiepileptic therapy, cytochrome P450 inhibition, carbamazepine, clobazam, vigabatrin, Dravet syndrome, focal epilepsy, seizure frequency, adverse events, drug tolerability
MeSH terms
Adolescent, Adult, Age Factors, Anticonvulsants, Child, Child, Preschool, Dioxolanes, Drug Therapy, Combination, Epilepsy, Epilepsies, Partial, Epilepsies, Myoclonic, Female, Follow-Up Studies, Humans, Infant, Infant, Newborn, Male, Placebos, Single-Blind Method, Treatment Outcome

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