The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Cellular and Network Mechanisms of Spike‐Wave Seizures
Abstract
Summary: Spike‐wave seizures are often considered a relatively “pure” form of epilepsy, with a uniform defect present in all patients and involvement of the whole brain homogenously. Here, we present evidence against these common misconceptions. Rather than a uniform disorder, spike‐wave rhythms arise from the normal inherent network properties of brain excitatory and inhibitory circuits, where they can be provoked by many different insults in several different brain networks. Here we discuss several different cellular and molecular mechanisms that may contribute to the generation of spike‐wave seizures, particularly in idiopathic generalized epilepsy. In addition, we discuss growing evidence that electrical, neuroimaging, and molecular changes in spike‐wave seizures do not involve the entire brain homogenously. Rather, spike‐wave discharges occur selectively in some thalamocortical networks, while sparing others. It is hoped that improved understanding of the heterogeneous defects and selective brain regions involved will ultimately lead to more effective treatments for spike‐wave seizures.
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Cites
Thalamocortical oscillations in the sleeping and aroused brain
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De Novo Mutations in the Sodium-Channel Gene SCN1A Cause Severe Myoclonic Epilepsy of Infancy
Claes, L., Del-Favero, J., Ceulemans, B., Lagae, L., Van Broeckhoven, C., & De Jonghe, P. (2001) · The American Journal of Human Genetics · doi:10.1086/320609 · Cited by 1,292
Sleep and arousal: thalamocortical mechanisms
McCormick, D. A., & Bal, T. (1997) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.20.1.185 · Cited by 1,267
Cited by
15q13.3 microdeletions increase risk of idiopathic generalized epilepsy.
Helbig, I., Mefford, H. C., Sharp, A. J., Guipponi, M., Fichera, M., Franke, A., Muhle, H., de Kovel, C., Baker, C., von Spiczak, S., et al. (2009) · Nature Genetics · doi:10.1038/ng.292 · Cited by 551
Seizure prediction – ready for a new era
Kuhlmann, L., Lehnertz, K., Richardson, M. P., Schelter, B., & Zaveri, H. P. (2018) · Nature Reviews Neurology · doi:10.1038/s41582-018-0055-2 · Cited by 450
Recurrent microdeletions at 15q11.2 and 16p13.11 predispose to idiopathic generalized epilepsies
de Kovel, C. G. F., Trucks, H., Helbig, I., Mefford, H. C., Baker, C., Leu, C., Kluck, C., Muhle, H., von Spiczak, S., Ostertag, P., et al. (2010) · Brain · doi:10.1093/brain/awp262 · Cited by 445
Developmental and epileptic encephalopathies: from genetic heterogeneity to phenotypic continuum
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Johnson, E. C. B., Ho, K., Yu, G.-Q., Das, M., Sanchez, P. E., Djukic, B., Lopez, I., Yu, X., Gill, M., Zhang, W., et al. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00393-5 · Cited by 73
Liu, D., Zhang, Y., Gharavi, R., Park, H. R., Lee, J., Siddiqui, S., Telljohann, R., Nassar, M. R., Cutler, R. G., Becker, K. G., et al. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13176 · Cited by 68
García‐Matas, S., Paul, R. K., Molina‐Martínez, P., Palacios, H., Gutierrez, V. M., Corpas, R., Pallas, M., Cristòfol, R., de Cabo, R., & Sanfeliu, C. (2015) · Aging Cell · doi:10.1111/acel.12259 · Cited by 22
Key roles of C2/GAP domains in SYNGAP1-related pathophysiology
Katsanevaki, D., Till, S. M., Buller-Peralta, I., Nawaz, M. S., Louros, S. R., Kapgal, V., Tiwari, S., Walsh, D., Anstey, N. J., Petrović, N. G., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114733 · Cited by 22
Metadata
- Authors
- Blumenfeld, H.
- Venue
- Epilepsia
- Publisher
- Wiley
- Published
- 2005-11
- Volume
- 46
- Issue
- s9
- Pages
- 21-33
- ISSN
- 0013-9580 (ISSN-L)
- 1528-1167
- OpenAlex
- W2021281924
- Cited by
- 454
- References
- 3
- FWCI
- 8.25
- Type
- journal article
- Language
- en
- Open access
- closed
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