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Cited by 436

The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.

A randomized trial of classical and medium‐chain triglyceride ketogenic diets in the treatment of childhood epilepsy

Open access
Neal, Elizabeth G., Chaffe, Hannah, Schwartz, Ruby H., Lawson, Margaret S., Edwards, Nicole, Fitzsimmons, Georgiana, Whitney, Andrea, Cross, J. Helen·2009·Epilepsia
DOI 10.1111/j.1528-1167.2008.01870.x
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Abstract

Summary: Purpose: To conduct the first randomized trial on classical and medium‐chain triglyceride (MCT) versions of the ketogenic diet, examining efficacy and tolerability after 3, 6, and 12 months. Methods: One hundred forty‐five children with intractable epilepsy were randomized to receive a classical or an MCT diet. Seizure frequency was assessed after 3, 6, and 12 months. Treatment withdrawals were documented. Tolerability was assessed by questionnaire, and blood ketone levels were measured. Results: Of the 61 children who started a classical diet and the 64 who started an MCT diet, data from 94 were available for analysis: 45 classical and 49 MCT. After 3, 6, and 12 months there were no statistically significant differences in mean percentage of baseline seizures between the two groups (3 months: classical 66.5%, MCT 68.9%; 6 months: classical 48.5%, MCT 67.6%; 12 months: classical 40.8%, MCT 53.2%; all p > 0.05). There were no significant differences between groups in numbers achieving greater than 50% or 90% seizure reduction. Serum acetoacetate and β‐hydroxybutyrate levels at 3 and 6 months were significantly higher in children on the classical diet (p < 0.01); this was the case at 12 months for acetoacetate. There were no significant differences in tolerability except increased reports in the classical group of lack of energy after 3 months and vomiting after 12 months. Discussion: This study has shown classical and MCT ketogenic diet protocols to be comparable in efficacy and tolerability; both ways of implementing the diet have their place in the treatment of childhood epilepsy.

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Metadata

Authors
Neal, E. G., Chaffe, H., Schwartz, R. H., Lawson, M. S., Edwards, N., Fitzsimmons, G., Whitney, A., & Cross, J. H.
Venue
Epilepsia
Publisher
Wiley
Published
2009-05
Volume
50
Issue
5
Pages
1109-1117
ISSN
  • 0013-9580 (ISSN-L)
  • 1528-1167
DOI
10.1111/j.1528-1167.2008.01870.x
OpenAlex
W1990800885
Cited by
436
References
26
FWCI
6.23
Type
journal article
Language
en
Open access
bronze

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The paper
Neal, E. G., Chaffe, H., Schwartz, R. H., Lawson, M. S., Edwards, N., Fitzsimmons, G., Whitney, A., & Cross, J. H. (2009). A randomized trial of classical and medium‐chain triglyceride ketogenic diets in the treatment of childhood epilepsy. Epilepsia. https://doi.org/10.1111/j.1528-1167.2008.01870.x

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.