Alcohol preference and voluntary alcohol intakes of inbred rat strains and the National Institutes of Health heterogeneous stock of rats
Abstract
The alcohol preference ratios and the daily free‐choice ethanol intakes (10% ethanol versus water) of the newly constituted National Institutes of Health (NIH) heterogeneous stock (N/Nih) rats, and of the eight inbred strains from which N/Nih derived, were measured. Among the eight inbred strains, ACI/N, WKY/N, F344/N, BUF/N, BN/ Ssn, WN/N, M520/N, and MR/N, the ACI exhibited the lowest preference and intakes and the MR and the M520 the highest The mean values for the N/Nih animals were intermediate among those of the inbred strains. The range of intake for the N/Nih rats was 0.06‐9.5 g/kg of body weight/day, indicating that they should serve as an appropriate foundation in selection studies for alcohol‐drinking preference.
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Selectively bred lines exhibit faster acquisition of alcohol self-administration.
“Selectively bred lines exhibited the faster acquisition of self-administration (Li and Lumeng, 1984;Moore and Lynch, 2015).”
From Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development (2021) · cites this paper as Li and Lumeng, 1984
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Becker, J. B., & Koob, G. F. (2016) · Pharmacological Reviews · doi:10.1124/pr.115.011163 · Cited by 725 · see citing works
Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development
Koob, G. F. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000083 · Cited by 337 · see citing works
Gongwer, M. A., Murphy, J. M., McBride, W. J., Lumeng, L., & Li, T.-K. (1989) · Alcohol · doi:10.1016/0741-8329(89)90089-x · Cited by 179 · see citing works
Self-citation
- Authors
- Ting‐Kai, U., & Lumeng, L.
- Affiliations
- Richard L. Roudebush VA Medical Center (US)
- Corresponding author
- Ting‐Kai, U
- Venue
- Alcoholism: Clinical and Experimental Research
- Publisher
- Wiley
- Published
- 1984-09
- Volume
- 8
- Issue
- 5
- Pages
- 485-486
- ISSN
- 0145-6008 (ISSN-L)
- 1530-0277
- OpenAlex
- W2065955598
- Cited by
- 195
- References
- 0
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 4 · 2022: 8 · 2021: 2 · 2020: 2 · 2019: 5 · 2018: 7 · 2017: 4 · 2016: 4 · 2015: 2 · 2014: 4 · 2013: 3 · 2012: 3
- FWCI
- 0.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Alcoholism Clinical and Experimental Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- alcohol preference, voluntary ethanol consumption, inbred rat strains, F344/N rats
- MeSH terms
- Alcohol Drinking, Alcoholism, Animals, Crosses, Genetic, Disease Models, Animal, Genotype, Humans, Rats, Inbred Strains, Rats
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