Hemoglobin‐Acetaldehyde Adducts Are Elevated in Women Carrying Alcohol‐Damaged Fetuses
Abstract
Alcohol use exceeding 3 to 5 daily drinks is associated with a 30% to 50% risk of delivering a child with fetal alcohol effects (FAE). FAE could be prevented if women were counseled and if they decreased their drinking. Therefore, we need sensitive and specific markers to detect alcohol abuse during pregnancy. We investigated whether acetaldehyde‐hemoglobin adducts (Hb‐Ach) could be such a marker. Using an antiserum specific for acetaldehyde‐generated epitopes in proteins, we measured the levels of Hb‐Ach from the red cells of 19 women visiting the outpatient department of pregnant alcohol abusers and from 14 non pregnant controls. The pregnant women were carefully followed to receive personal antenatal care and intensive counseling on alcohol. Nevertheless, eight of the women delivered infants with FAE. The remaining 11 women had healthy infants, although only four of them stopped drinking totally. The highest concentrations of Hb‐Ach were found from women who subsequently delivered children with FAE. When compared with the pregnant women abstaining from ethanol the Hb‐Ach values were found to be elevated in five of eight (63%) of the women who gave birth to children with FAE, whereas only in two/seven (28%) of the mothers who despite drinking delivered healthy children. Hb‐Ach measurements during pregnancy may prove to be useful to monitor the compliance of women withdrawing from alcohol and to distinguish the mothers at risk of affected offspring. The studies also support a pathophysiological role of acetaldehyde in producing ethanol‐associated fetal injury.
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After alcohol consumption, AA adducts are produced in blood erythrocytes and are correlated with the incidence of fetal alcohol spectrum disorders (FASDs).
“After alcohol consumption, AA adducts are produced in blood erythrocytes and are also correlated with the incidence of fetal alcohol spectrum disorders (FASDs)257,258.”
From Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury (2021) · cites this paper as [258]
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Rungratanawanich, W., Qu, Y., Wang, X., Essa, M. M., & Song, B.-J. (2021) · Experimental & Molecular Medicine · doi:10.1038/s12276-021-00561-7 · Cited by 411 · see citing works
- Authors
- Niemelä, O., Halmesmäki, E., & Ylikorkala, O.
- Affiliations
- University of Oulu (FI)
- Helsinki University Hospital (FI)
- Corresponding author
- Niemelä, Onni
- ORCID
- Niemelä, Onni
- Venue
- Alcoholism: Clinical and Experimental Research
- Publisher
- Wiley
- Published
- 1991-11
- Volume
- 15
- Issue
- 6
- Pages
- 1007-1010
- ISSN
- 0145-6008 (ISSN-L)
- 1530-0277
- OpenAlex
- W2146628082
- Cited by
- 34
- References
- 29
- Citations by year
- 2024: 2 · 2023: 1 · 2021: 1 · 2018: 1 · 2016: 2 · 2014: 2 · 2012: 1
- FWCI
- 1.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Alcoholism Clinical and Experimental Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- fetal alcohol effects, alcohol use during pregnancy, maternal alcohol abuse, prenatal counseling
- MeSH terms
- Acetaldehyde, Alcohol Drinking, Birth Weight, Dose-Response Relationship, Drug, Female, Follow-Up Studies, Hemoglobins, Humans, Infant, Infant, Newborn, Pregnancy, Prenatal Diagnosis, Protein Binding, Fetal Alcohol Spectrum Disorders
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