Parallels to Early Onset Alcohol Use in the Relationship of Early Onset Smoking with Drug Use and DSM‐IV Drug and Depressive Disorders: Findings From the National Longitudinal Epidemiologic Survey
Abstract
This paper endeavored to determine (1) if early onset of regular tobacco use is as predictive of drug use and depressive disorders as it is of alcohol use disorders; and (2) if a biological commonality, as measured by a family history of alcoholism and both early onset and severity of disease, among all three disorders can be evidenced in a large nationally representative sample. Prevalences of lifetime drug use, drug abuse and dependence, and major depressive disorders, as well as indices of their severity, were compared among smoking groups defined by age at onset of regular tobacco use and among nonsmokers. Linear logistic regression analyses, controlling for important covariates, including a family history positive for alcoholism, were conducted to assess the relationship between age at smoking onset and drug use, abuse and dependence, as well as depressive disorders. Both objectives were met. Moreover, results suggest that smoking may play an equally, if not even more, insidious role than drinking in the use and development of dependence on illicit substances and depression.
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Nicotine use in adolescence is linked with later abuse of different drug categories, such as alcohol, opiate drugs, or cocaine.
“Nicotine is also posited to act as a “gateway drug”, where its use in adolescence is linked with later abuse of different drug categories, such as alcohol, opiate drugs, or cocaine [3, 13–15].”
From Adolescent nicotine exposure and persistent neurocircuitry changes: unveiling lifelong psychiatric risks (2025) · cites this paper as [15]
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Self-citationWagner, F. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00367-0 · Cited by 739 · see citing works
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Synergistic interaction between nicotine and social rewards in adolescent male rats
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Developmental effects of acute, chronic, and withdrawal from chronic nicotine on fear conditioning
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“Nicotine is also posited to act as a “ gateway drug ” , where its use in adolescence is linked with later abuse of different drug categories, such as alcohol, opiate drugs, or cocaine [3, 13 – 15].”
- Authors
- Hanna, E. Z., & Grant, B. F.
- Affiliations
- Harvard University (US)
- Corresponding author
- Hanna, Eleanor Z.
- Venue
- Alcoholism: Clinical and Experimental Research
- Publisher
- Wiley
- Published
- 1999-03
- Volume
- 23
- Issue
- 3
- Pages
- 513-522
- ISSN
- 0145-6008 (ISSN-L)
- 1530-0277
- OpenAlex
- W2119431039
- Cited by
- 103
- References
- 1
- Citations by year
- 2025: 2 · 2023: 2 · 2022: 2 · 2021: 1 · 2019: 1 · 2018: 3 · 2016: 5 · 2015: 6 · 2013: 3 · 2012: 3
- FWCI
- 3.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Alcoholism Clinical and Experimental Research (publishedVersion)
- PubMed (publishedVersion)
- Alcoholism Clinical and Experimental Research
- Topics
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Keywords
- early smoking onset, smoking initiation age, tobacco use, drug use, drug addiction, drug abuse, major depressive disorder, family history of alcoholism, alcoholism, substance dependence, depression
- MeSH terms
- Adolescent, Adult, Alcohol Drinking, Depressive Disorder, Female, Humans, Longitudinal Studies, Male, Psychiatric Status Rating Scales, Risk Factors, Smoking, Tobacco Use Disorder, United States, Age of Onset, Diagnosis, Dual (Psychiatry), Substance-Related Disorders
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